Role of apoptosis in HIV disease pathogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-09

AUTHORS

Naoki Oyaizu, Savita Pahwa

ABSTRACT

After approximately one and a half decades of intensive studies, the exact mechanisms to explain HIV-mediated cytopathicity are still enigmatic and need closer scrutiny. There has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing a killing of infected cells by HIV-1 and the latter emphasizing indirect mechanisms wherein HIV or its soluble component(s) alter CD4 T-cell function and induce susceptibility to apoptosis. Accumulating evidence points to the notion that apoptosis might be a major contributor to the depletion of CD4 T-cells in HIV infection. This review summarizes current information about the regulatory mechanisms of T-cell apoptosis and the role of apoptosis in HIV pathogenesis with the goal of providing an integrated view of HIV cytopathicity. More... »

PAGES

217-231

References to SciGraph publications

  • 1994-01. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77 in NATURE
  • 1994-01. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas in NATURE
  • 1972-08. Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics in BRITISH JOURNAL OF CANCER
  • 1995-04. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL in NATURE
  • 1992-03. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis in NATURE
  • 1995-01. Viral dynamics in human immunodeficiency virus type 1 infection in NATURE
  • 1994-02. How B and T cells talk to each other in NATURE
  • 1995-02. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes in NATURE MEDICINE
  • 1995-02. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas in NATURE
  • 1990-09. Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen in NATURE
  • 1993-06. HIV induces thymus depletion in vivo in NATURE
  • 1995-01. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection in NATURE
  • 1995-02. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) in NATURE
  • 1993-03-25. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS in NATURE
  • 1994-05. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax in NATURE
  • 1995-05-04. Involvement of an ICE-like protease in Fas-mediated apoptosis in NATURE
  • 1991-10. lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis in NATURE
  • 1989-04. Severe immunodeficiency disease induced by a defective murine leukaemia virus in NATURE
  • 1986-10-23. Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein in NATURE
  • 1995-05-04. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis in NATURE
  • 1995-04. Induction of apoptosis by the Bcl-2 homologue Bak in NATURE
  • 1993-03-25. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease in NATURE
  • 1995-04. Programmed cell death and Bcl-2 protection in very low oxygen in NATURE
  • 1986-07. Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity in NATURE
  • 1995-02. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation in NATURE
  • Journal

    TITLE

    Journal of Clinical Immunology

    ISSUE

    5

    VOLUME

    15

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01540879

    DOI

    http://dx.doi.org/10.1007/bf01540879

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022605986

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8537466


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