Double-blind comparison of cisapride and cimetidine in treatment of reflux esophagitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

J. P. Galmiche, B. Fraitag, B. Filoche, M. Evreux, J. Vitaux, P. Zeitoun, J. Fournet, J. C. Soule

ABSTRACT

In a double-blind, randomized, comparative trial of the prokinetic drug cisapride and the H2-blocker cimetidine, mucosal healing and changes in symptoms of gastroesophageal reflux were evaluated in patients with erosive reflux esophagitis. The patients were treated with either cisapride, 10 mg four times a day (N=36) or cimetidine, 400 mg four times a day (N=37) for six weeks, or for 12 weeks if mucosal healing was not obtained by week 6. Upon entry, two thirds of the patients in each group had grade I (Savary-Miller) esophagitis, and the remainder grade II or III. At the end of treatment, endoscopy showed mucosal healing in 56% (38–72%; 95% confidence interval) of cisapride and 57% (39–73%; 95% confidence interval) of cimetidine patients. After six weeks, both drugs significantly (P<0.01) decreased the intensity and frequency of heartburn, regurgitation, and the postural syndrome. No significant inter group differences were found regarding endoscopic parameters or the improvement of heartburn and regurgitation. Concomitant antacid use was also comparable. Adverse effects were reported by four cisapride and nine cimetidine patients. These results indicate that the effects of cisapride compare well with those of cimetidine in terms of both esophageal mucosal healing and symptom relief. More... »

PAGES

649-655

References to SciGraph publications

  • 1988-12. Cisapride in DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01540415

    DOI

    http://dx.doi.org/10.1007/bf01540415

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008807256

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2331957


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