Antigen expression by somatic cell hybrids of a murine embryonal carcinoma cell with thymocytes and L cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-03

AUTHORS

Peter W. Andrews, Peter N. Goodfellow

ABSTRACT

Thymocyte x PCC4azaR (a murine embryonal carcinoma cell) hybrid cells resembled PCC4azaR. They continued to express two embryonic antigens (SSEA-1 and 3C4-10) found on PCC4azaR, but did not express the thymocyte antigens Thy-1 and Ly-2. However, H-2Kk of thymocyte origin continued to be expressed, while H-2Db of PCC4azaR origin was not reexpressed. This is consistent with H-2 expression being subject to cis control. In syngeneic hosts these hybrids formed tumors containing stem cells and differentiated derivatives. In contrast, an L-cell x PCC4azaR hybrid resembled the L-cell parent, did not express SSEA-1 and 3C4-10, but did express both H-2Kk and H-2Db. In syngeneic hosts this hybrid formed undifferentiated sarcomas. More... »

PAGES

271-284

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01538801

DOI

http://dx.doi.org/10.1007/bf01538801

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015844949

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6994266


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