Serum insulin-like growth factor II in chronic liver disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-03

AUTHORS

Tetsuo Hayakawa, Takaharu Kondo, Tokimune Shibata, Motoji Kitagawa, Hideki Ono, Yuzo Sakai, Katsumoto Kato, Naoyuki Katada, Yoshiyuki Sugimoto, Masayuki Takeichi, Ryohei Yamamoto, Naomi Kodaira

ABSTRACT

Insulin-like growth factor II is secreted primarily by the liver and is reported to be transcribed in many primary hepatocellular carcinoma (PHC) cell lines. We have studied diagnostic significance of serum IGF-II in chronic liver diseases using specific enzyme immunoassay. Serum IGF-II levels (mean +/- SE) were decreased in chronic hepatitis (538 +/- 51 ng/ml; N = 29), liver cirrhosis (427 +/- 45; 50) and PHC (260 +/- 41; 17) compared to controls (830 +/- 49; 57). Serum IGF-II was not different from controls in any of nonhepatic diseases such as diabetes (1032 +/- 97; 19) pancreatic cancer (1413 +/- 282; 8), chronic pancreatitis (999 +/- 126; 17), peptic ulcer (1186 +/- 43; 11), irritable bowel syndrome (1002 +/- 109; 12), gastrointestinal tract cancer (1250 +/- 216; 21) and chronic renal failure (733 +/- 135; 14). In liver diseases serum IGF-II showed a significant correlation with liver function test (negative with retention of indocyanine green and total bile acids; positive with albumin, thrombo-test, and cholinesterase). These results suggest that serum IGF-II reflects a reduced production of IGF-II in the liver and that it can be an index for the residual capacity of liver function. More... »

PAGES

338-342

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01536252

DOI

http://dx.doi.org/10.1007/bf01536252

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2537715


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