Splenectomy before tumor inoculation prolongs the survival time of cachectic mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-07

AUTHORS

Kuniyasu Soda, Masanobu Kawakami, Shojirou Takagi, Akiyoshi Kashii, Michio Miyata

ABSTRACT

The effects of splenectomy on the development of cachexia, tumor growth and animal survival were studied in tumor-bearing CDF1 mice. Mice were inoculated with two subclones of colon 26 adenocarcinoma, clone 20 (with a potent capacity to induce cachexia) and clone 5 (without such activity), and underwent splenectomy before or after tumor inoculation. Splenectomy significantly prolonged the survival of mice bearing clone 20 when it was performed prior to tumor inoculation, although the progression of cachexia and tumor growth were not affected. The survival rate was higher in splenectomized than it was in nonsplenectomized mice 20-40 days after tumor inoculation. Such effects on survival were not observed, however, in mice splenectomized after inoculation with clone 20 or in mice that underwent splenectomy either before or after inoculation with clone 5. The decrease of peripheral blood lymphocyte count observed in mice bearing clone 20 was magnified when splenectomy was performed before tumor inoculation, but the serum levels of tumor necrosis factor and interleukin-6 were comparable. These results indicate that cancer death from cachexia is not directly attributable to enhanced catabolism. The mechanism by which splenectomy ameliorates the survival of cachectic mice remains to be studied, although several changes observed in the splenectomized mice after inoculation, including decreases in the peripheral blood L3T4+ cells and Lyt-2+ cells on the 9th day and 15th day respectively, and increase in the L3T4+/Lyt-2+ cell ratio on the 15th day suggest the involvement of the modified host's immune response. More... »

PAGES

203-209

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01516994

DOI

http://dx.doi.org/10.1007/bf01516994

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008756118

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7489562


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cachexia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clone Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred DBA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Splenectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocyte Subsets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Integrated Medicine and Surgery, Omiya Medical Center, Jichi Medical School, 1-847 Amanuma-cho, 330, Omiya, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soda", 
        "givenName": "Kuniyasu", 
        "id": "sg:person.0730445512.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730445512.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine, Omiya Medical Center, Jichi Medical School, Omiya, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawakami", 
        "givenName": "Masanobu", 
        "id": "sg:person.01143767626.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143767626.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine, Omiya Medical Center, Jichi Medical School, Omiya, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takagi", 
        "givenName": "Shojirou", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Integrated Medicine and Surgery, Omiya Medical Center, Jichi Medical School, 1-847 Amanuma-cho, 330, Omiya, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kashii", 
        "givenName": "Akiyoshi", 
        "id": "sg:person.0601167755.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601167755.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Integrated Medicine and Surgery, Omiya Medical Center, Jichi Medical School, 1-847 Amanuma-cho, 330, Omiya, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyata", 
        "givenName": "Michio", 
        "id": "sg:person.0622000256.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622000256.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0022-4804(90)90011-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004469909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.2930420113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005880342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-2918(05)80001-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014832994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90028-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017749916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.154.3.631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024022385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/320584a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026920872", 
          "https://doi.org/10.1038/320584a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/320584a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026920872", 
          "https://doi.org/10.1038/320584a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800780904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027559701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1990.tb00175.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028459875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000234652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030598759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032103109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(89)80114-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033917715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1983.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037892377", 
          "https://doi.org/10.1038/bjc.1983.41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1983.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037892377", 
          "https://doi.org/10.1038/bjc.1983.41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.2930530213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039624827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.105.6.1673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045283899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910610416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046832793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.2930470309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046863309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1994.tb02917.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047373239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1994.tb02917.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047373239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199010000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050077181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199010000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050077181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910620317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050356737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830210806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051481238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197503)35:3<687::aid-cncr2820350322>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052305162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-128-5-2657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064264270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076886119", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077306968", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077811376", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078509009", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078612038", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078652399", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079662952", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-349-86029-6_50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086226857", 
          "https://doi.org/10.1007/978-1-349-86029-6_50"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-07", 
    "datePublishedReg": "1995-07-01", 
    "description": "The effects of splenectomy on the development of cachexia, tumor growth and animal survival were studied in tumor-bearing CDF1 mice. Mice were inoculated with two subclones of colon 26 adenocarcinoma, clone 20 (with a potent capacity to induce cachexia) and clone 5 (without such activity), and underwent splenectomy before or after tumor inoculation. Splenectomy significantly prolonged the survival of mice bearing clone 20 when it was performed prior to tumor inoculation, although the progression of cachexia and tumor growth were not affected. The survival rate was higher in splenectomized than it was in nonsplenectomized mice 20-40 days after tumor inoculation. Such effects on survival were not observed, however, in mice splenectomized after inoculation with clone 20 or in mice that underwent splenectomy either before or after inoculation with clone 5. The decrease of peripheral blood lymphocyte count observed in mice bearing clone 20 was magnified when splenectomy was performed before tumor inoculation, but the serum levels of tumor necrosis factor and interleukin-6 were comparable. These results indicate that cancer death from cachexia is not directly attributable to enhanced catabolism. The mechanism by which splenectomy ameliorates the survival of cachectic mice remains to be studied, although several changes observed in the splenectomized mice after inoculation, including decreases in the peripheral blood L3T4+ cells and Lyt-2+ cells on the 9th day and 15th day respectively, and increase in the L3T4+/Lyt-2+ cell ratio on the 15th day suggest the involvement of the modified host's immune response.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01516994", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "name": "Splenectomy before tumor inoculation prolongs the survival time of cachectic mice", 
    "pagination": "203-209", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "29b791c9ed03846b5a04fe47ba4500cf10da30fceeb519f4b17a3ea0ee30b613"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7489562"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01516994"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008756118"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01516994", 
      "https://app.dimensions.ai/details/publication/pub.1008756118"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000530.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF01516994"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01516994'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01516994'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01516994'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01516994'


 

This table displays all metadata directly associated to this object as RDF triples.

253 TRIPLES      21 PREDICATES      75 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01516994 schema:about N009e4cf0a41a4b77b57e968cc709c94e
2 N2cf66706f59c4edcafbb16e0b16ec2ac
3 N44110e26728144f8bff03e16ee7e1eb9
4 N582bed32a02f47ceaacb7429fef2be86
5 N89e0d0f8f436446a9f2def0f29650f61
6 N8d16d267f97e450aa709a8dad12d94b8
7 N9caeef82025d47678b8f878073737b5a
8 Na53e3d85f60c46b5a3374d577574193a
9 Nac54815020f948cd9349d5aa989c6721
10 Nb29aa0b06b0e491db933ec9241eeef96
11 Nba27c13d413e41c6b198dd78a035ce1e
12 Nc69355aa7bcc4705b6f629f13d8b4605
13 Nd70feb83b8204959ad63b8fb9236da48
14 Ne004f2c8c73a4b0ca5d2110b508c2f9f
15 Neeb16b8669624430a5dfc9f5b918b9d5
16 Nf99a9888ec094dfd8072a2f6581d1743
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N17a8864c1c5d40b48d682a8d045f9618
20 schema:citation sg:pub.10.1007/978-1-349-86029-6_50
21 sg:pub.10.1038/320584a0
22 sg:pub.10.1038/bjc.1983.41
23 https://app.dimensions.ai/details/publication/pub.1076886119
24 https://app.dimensions.ai/details/publication/pub.1077306968
25 https://app.dimensions.ai/details/publication/pub.1077811376
26 https://app.dimensions.ai/details/publication/pub.1078509009
27 https://app.dimensions.ai/details/publication/pub.1078612038
28 https://app.dimensions.ai/details/publication/pub.1078652399
29 https://app.dimensions.ai/details/publication/pub.1079662952
30 https://doi.org/10.1002/1097-0142(197503)35:3<687::aid-cncr2820350322>3.0.co;2-u
31 https://doi.org/10.1002/bjs.1800780904
32 https://doi.org/10.1002/eji.1830210806
33 https://doi.org/10.1002/ijc.2910610416
34 https://doi.org/10.1002/ijc.2910620317
35 https://doi.org/10.1002/jso.2930420113
36 https://doi.org/10.1002/jso.2930470309
37 https://doi.org/10.1002/jso.2930530213
38 https://doi.org/10.1016/0022-4804(90)90011-p
39 https://doi.org/10.1016/0092-8674(87)90028-6
40 https://doi.org/10.1016/s0006-291x(89)80114-7
41 https://doi.org/10.1016/s0149-2918(05)80001-3
42 https://doi.org/10.1084/jem.154.3.631
43 https://doi.org/10.1097/00005373-199010000-00012
44 https://doi.org/10.1111/j.1349-7006.1994.tb02917.x
45 https://doi.org/10.1111/j.1749-6632.1990.tb00175.x
46 https://doi.org/10.1159/000234652
47 https://doi.org/10.1172/jci115767
48 https://doi.org/10.1210/endo-128-5-2657
49 https://doi.org/10.1378/chest.105.6.1673
50 schema:datePublished 1995-07
51 schema:datePublishedReg 1995-07-01
52 schema:description The effects of splenectomy on the development of cachexia, tumor growth and animal survival were studied in tumor-bearing CDF1 mice. Mice were inoculated with two subclones of colon 26 adenocarcinoma, clone 20 (with a potent capacity to induce cachexia) and clone 5 (without such activity), and underwent splenectomy before or after tumor inoculation. Splenectomy significantly prolonged the survival of mice bearing clone 20 when it was performed prior to tumor inoculation, although the progression of cachexia and tumor growth were not affected. The survival rate was higher in splenectomized than it was in nonsplenectomized mice 20-40 days after tumor inoculation. Such effects on survival were not observed, however, in mice splenectomized after inoculation with clone 20 or in mice that underwent splenectomy either before or after inoculation with clone 5. The decrease of peripheral blood lymphocyte count observed in mice bearing clone 20 was magnified when splenectomy was performed before tumor inoculation, but the serum levels of tumor necrosis factor and interleukin-6 were comparable. These results indicate that cancer death from cachexia is not directly attributable to enhanced catabolism. The mechanism by which splenectomy ameliorates the survival of cachectic mice remains to be studied, although several changes observed in the splenectomized mice after inoculation, including decreases in the peripheral blood L3T4+ cells and Lyt-2+ cells on the 9th day and 15th day respectively, and increase in the L3T4+/Lyt-2+ cell ratio on the 15th day suggest the involvement of the modified host's immune response.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf N9a2a5454914e434db6d05b73810120fb
57 Nc3fcef33b424489990d3b0655a103374
58 sg:journal.1096240
59 schema:name Splenectomy before tumor inoculation prolongs the survival time of cachectic mice
60 schema:pagination 203-209
61 schema:productId N2a65f1dbc5b740b5b7e6c4d58d19e6df
62 N6f70cc00c2dd45ed9c7a55f478c7d323
63 N8e324cb9b07f4f7c953169e0d2b2137e
64 N9d6f4a4d3b274cdb8764256e67596f52
65 Nc876ad9511104bda95951662191815d1
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008756118
67 https://doi.org/10.1007/bf01516994
68 schema:sdDatePublished 2019-04-10T14:14
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher Nb44884fdf79d43c584e7a1d5e9358141
71 schema:url http://link.springer.com/10.1007%2FBF01516994
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N009e4cf0a41a4b77b57e968cc709c94e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Cachexia
77 rdf:type schema:DefinedTerm
78 N17a8864c1c5d40b48d682a8d045f9618 rdf:first sg:person.0730445512.27
79 rdf:rest N6e2a662f4e734a84ad5e2cd1659d6562
80 N2a65f1dbc5b740b5b7e6c4d58d19e6df schema:name dimensions_id
81 schema:value pub.1008756118
82 rdf:type schema:PropertyValue
83 N2cf66706f59c4edcafbb16e0b16ec2ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Survival Analysis
85 rdf:type schema:DefinedTerm
86 N44110e26728144f8bff03e16ee7e1eb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Mice, Inbred BALB C
88 rdf:type schema:DefinedTerm
89 N582bed32a02f47ceaacb7429fef2be86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Colonic Neoplasms
91 rdf:type schema:DefinedTerm
92 N6e2a662f4e734a84ad5e2cd1659d6562 rdf:first sg:person.01143767626.39
93 rdf:rest Nd7478cf44e8a4ddc8d9f12b138e826bb
94 N6f70cc00c2dd45ed9c7a55f478c7d323 schema:name pubmed_id
95 schema:value 7489562
96 rdf:type schema:PropertyValue
97 N7edc4934757b46249c3524104c7e43dd schema:name Department of Integrated Medicine and Surgery, Omiya Medical Center, Jichi Medical School, 1-847 Amanuma-cho, 330, Omiya, Saitama, Japan
98 rdf:type schema:Organization
99 N8267c1a7a5ca45208e8c0df1ae4acfe1 schema:name Department of Integrated Medicine and Surgery, Omiya Medical Center, Jichi Medical School, 1-847 Amanuma-cho, 330, Omiya, Saitama, Japan
100 rdf:type schema:Organization
101 N89e0d0f8f436446a9f2def0f29650f61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Tumor Necrosis Factor-alpha
103 rdf:type schema:DefinedTerm
104 N8d16d267f97e450aa709a8dad12d94b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name T-Lymphocyte Subsets
106 rdf:type schema:DefinedTerm
107 N8e324cb9b07f4f7c953169e0d2b2137e schema:name doi
108 schema:value 10.1007/bf01516994
109 rdf:type schema:PropertyValue
110 N96394d30a449434b9c51280651a984f1 schema:name Department of Internal Medicine, Omiya Medical Center, Jichi Medical School, Omiya, Saitama, Japan
111 rdf:type schema:Organization
112 N9a2a5454914e434db6d05b73810120fb schema:volumeNumber 41
113 rdf:type schema:PublicationVolume
114 N9caeef82025d47678b8f878073737b5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Male
116 rdf:type schema:DefinedTerm
117 N9d6f4a4d3b274cdb8764256e67596f52 schema:name nlm_unique_id
118 schema:value 8605732
119 rdf:type schema:PropertyValue
120 Na53e3d85f60c46b5a3374d577574193a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Interleukin-6
122 rdf:type schema:DefinedTerm
123 Nac54815020f948cd9349d5aa989c6721 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mice, Inbred DBA
125 rdf:type schema:DefinedTerm
126 Nb29aa0b06b0e491db933ec9241eeef96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Animals
128 rdf:type schema:DefinedTerm
129 Nb44884fdf79d43c584e7a1d5e9358141 schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 Nb8b5a0e9cdbd4e5db82f9e778cfc7134 schema:name Department of Internal Medicine, Omiya Medical Center, Jichi Medical School, Omiya, Saitama, Japan
132 rdf:type schema:Organization
133 Nba27c13d413e41c6b198dd78a035ce1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Splenectomy
135 rdf:type schema:DefinedTerm
136 Nbbdfa607dce74f05b8e6a069d7941735 rdf:first sg:person.0622000256.27
137 rdf:rest rdf:nil
138 Nc3fcef33b424489990d3b0655a103374 schema:issueNumber 4
139 rdf:type schema:PublicationIssue
140 Nc69355aa7bcc4705b6f629f13d8b4605 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Clone Cells
142 rdf:type schema:DefinedTerm
143 Nc876ad9511104bda95951662191815d1 schema:name readcube_id
144 schema:value 29b791c9ed03846b5a04fe47ba4500cf10da30fceeb519f4b17a3ea0ee30b613
145 rdf:type schema:PropertyValue
146 Ncee6c1cee727418881bede09403d77b2 schema:affiliation Nb8b5a0e9cdbd4e5db82f9e778cfc7134
147 schema:familyName Takagi
148 schema:givenName Shojirou
149 rdf:type schema:Person
150 Nd70feb83b8204959ad63b8fb9236da48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Mice
152 rdf:type schema:DefinedTerm
153 Nd7478cf44e8a4ddc8d9f12b138e826bb rdf:first Ncee6c1cee727418881bede09403d77b2
154 rdf:rest Nf1dd783f2b574a1c87060224d47efaaf
155 Ndc8764497ce14aa6866c744857e5ee88 schema:name Department of Integrated Medicine and Surgery, Omiya Medical Center, Jichi Medical School, 1-847 Amanuma-cho, 330, Omiya, Saitama, Japan
156 rdf:type schema:Organization
157 Ne004f2c8c73a4b0ca5d2110b508c2f9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Neoplasm Transplantation
159 rdf:type schema:DefinedTerm
160 Neeb16b8669624430a5dfc9f5b918b9d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adenocarcinoma
162 rdf:type schema:DefinedTerm
163 Nf1dd783f2b574a1c87060224d47efaaf rdf:first sg:person.0601167755.13
164 rdf:rest Nbbdfa607dce74f05b8e6a069d7941735
165 Nf99a9888ec094dfd8072a2f6581d1743 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Leukocyte Count
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
172 schema:name Oncology and Carcinogenesis
173 rdf:type schema:DefinedTerm
174 sg:journal.1096240 schema:issn 0340-7004
175 1432-0851
176 schema:name Cancer Immunology, Immunotherapy
177 rdf:type schema:Periodical
178 sg:person.01143767626.39 schema:affiliation N96394d30a449434b9c51280651a984f1
179 schema:familyName Kawakami
180 schema:givenName Masanobu
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143767626.39
182 rdf:type schema:Person
183 sg:person.0601167755.13 schema:affiliation N8267c1a7a5ca45208e8c0df1ae4acfe1
184 schema:familyName Kashii
185 schema:givenName Akiyoshi
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601167755.13
187 rdf:type schema:Person
188 sg:person.0622000256.27 schema:affiliation N7edc4934757b46249c3524104c7e43dd
189 schema:familyName Miyata
190 schema:givenName Michio
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622000256.27
192 rdf:type schema:Person
193 sg:person.0730445512.27 schema:affiliation Ndc8764497ce14aa6866c744857e5ee88
194 schema:familyName Soda
195 schema:givenName Kuniyasu
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730445512.27
197 rdf:type schema:Person
198 sg:pub.10.1007/978-1-349-86029-6_50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086226857
199 https://doi.org/10.1007/978-1-349-86029-6_50
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/320584a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026920872
202 https://doi.org/10.1038/320584a0
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/bjc.1983.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037892377
205 https://doi.org/10.1038/bjc.1983.41
206 rdf:type schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1076886119 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1077306968 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1077811376 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1078509009 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1078612038 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1078652399 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1079662952 schema:CreativeWork
214 https://doi.org/10.1002/1097-0142(197503)35:3<687::aid-cncr2820350322>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1052305162
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/bjs.1800780904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027559701
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/eji.1830210806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051481238
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/ijc.2910610416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046832793
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/ijc.2910620317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050356737
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/jso.2930420113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005880342
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/jso.2930470309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046863309
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/jso.2930530213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039624827
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/0022-4804(90)90011-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1004469909
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0092-8674(87)90028-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017749916
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0006-291x(89)80114-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033917715
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0149-2918(05)80001-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014832994
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1084/jem.154.3.631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024022385
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1097/00005373-199010000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050077181
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1349-7006.1994.tb02917.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047373239
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1749-6632.1990.tb00175.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028459875
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1159/000234652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030598759
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1172/jci115767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032103109
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1210/endo-128-5-2657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064264270
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1378/chest.105.6.1673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045283899
253 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...