Interferon-α activates cytotoxic function but inhibits interleukin-2-mediated proliferation and tumor necrosis factor-α secretion by immature human natural killer cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-01

AUTHORS

Anahid Jewett, Benjamin Bonavida

ABSTRACT

Natural killer (NK) cells play an important role in host defense mechanisms against infection and neoplasia. Interferon-alpha (IFN-alpha) has been shown to activate NK cells and to augment their cytotoxic activity, albeit its role in the maturation pathway of NK cells has not been elucidated. The present study examined whether IFN-alpha activates the immature NK subset (Free cells) to become cytotoxic and also ascertained whether IFN-alpha uses the same pathway of activation as that mediated by interleukin-2 (IL-2). Incubation of sorted Free cells overnight with IFN-alpha resulted in augmentation of their cytotoxic function against NK sensitive target cells. The enhanced cytotoxic activity was not accompanied by a new recruitment of NK-target binder cells but by an increase in the frequency of killer cells in the conjugate fraction. Activation of the Free subset by IFN-alpha resulted in upregulation of CD69, CD11b, and CD2 surface expression and stimulated secretion of IFN-gamma. Unlike IL-2, IFN-alpha did not stimulate the Free cells to proliferate or secrete TNF-alpha and activation of cytotoxicity and modulation of surface antigens by IFN-alpha were independent of TNF-alpha. The failure of IFN-alpha to stimulate secretion and proliferation by Free cells appeared to be mediated by negative signals. This was corroborated in experiments demonstrating that when Free cells were cultured with both IFN-alpha and IL-2, a significant inhibition was observed for both the IL-2 dependent secretion of TNF-alpha and proliferation. These results demonstrate that IFN-alpha serves as both an activator and a regulator of NK function. Further, activation of the immature Free NK cells by IL-2 and IFN-alpha proceeds by TNF-alpha- dependent and independent pathways, respectively. The findings also support our contention that the mechanism of activation of the cytotoxic machinery of NK cells is not linked to the mechanism of activation of cytokine secretion and/or proliferation. More... »

PAGES

35-44

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01489488

DOI

http://dx.doi.org/10.1007/bf01489488

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025611527

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7759599


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytotoxicity, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Killer Cells, Natural", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Microbiology and Immunology, UCLA School of Medicine, University of California at Los Angeles, 90024, California"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jewett", 
        "givenName": "Anahid", 
        "id": "sg:person.0602347273.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602347273.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Microbiology and Immunology, UCLA School of Medicine, University of California at Los Angeles, 90024, California"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonavida", 
        "givenName": "Benjamin", 
        "id": "sg:person.014442031637.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014442031637.81"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/eji.1830191021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001659221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1990.tb15478.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003745809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.175.3.779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004613294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-1229(89)90120-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006273651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2260345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009915125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2260345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009915125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910480328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010384559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.7.2061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014129521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830210726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015873598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19920515)69:10<2525::aid-cncr2820691023>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028100917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cimm.1993.1236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033788717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.172.6.1729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035169974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01741057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037437629", 
          "https://doi.org/10.1007/bf01741057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01741057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037437629", 
          "https://doi.org/10.1007/bf01741057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.16.6063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038900333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.171.3.745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044223310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00047471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046220680", 
          "https://doi.org/10.1007/bf00047471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00047471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046220680", 
          "https://doi.org/10.1007/bf00047471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0008-8749(90)90261-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047554930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01665006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048789018", 
          "https://doi.org/10.1007/bf01665006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01665006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048789018", 
          "https://doi.org/10.1007/bf01665006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.163.6.1405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052932086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078904247", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079571146", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079647824", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081593731", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082463962", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082798253", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-01", 
    "datePublishedReg": "1995-01-01", 
    "description": "Natural killer (NK) cells play an important role in host defense mechanisms against infection and neoplasia. Interferon-alpha (IFN-alpha) has been shown to activate NK cells and to augment their cytotoxic activity, albeit its role in the maturation pathway of NK cells has not been elucidated. The present study examined whether IFN-alpha activates the immature NK subset (Free cells) to become cytotoxic and also ascertained whether IFN-alpha uses the same pathway of activation as that mediated by interleukin-2 (IL-2). Incubation of sorted Free cells overnight with IFN-alpha resulted in augmentation of their cytotoxic function against NK sensitive target cells. The enhanced cytotoxic activity was not accompanied by a new recruitment of NK-target binder cells but by an increase in the frequency of killer cells in the conjugate fraction. Activation of the Free subset by IFN-alpha resulted in upregulation of CD69, CD11b, and CD2 surface expression and stimulated secretion of IFN-gamma. Unlike IL-2, IFN-alpha did not stimulate the Free cells to proliferate or secrete TNF-alpha and activation of cytotoxicity and modulation of surface antigens by IFN-alpha were independent of TNF-alpha. The failure of IFN-alpha to stimulate secretion and proliferation by Free cells appeared to be mediated by negative signals. This was corroborated in experiments demonstrating that when Free cells were cultured with both IFN-alpha and IL-2, a significant inhibition was observed for both the IL-2 dependent secretion of TNF-alpha and proliferation. These results demonstrate that IFN-alpha serves as both an activator and a regulator of NK function. Further, activation of the immature Free NK cells by IL-2 and IFN-alpha proceeds by TNF-alpha- dependent and independent pathways, respectively. The findings also support our contention that the mechanism of activation of the cytotoxic machinery of NK cells is not linked to the mechanism of activation of cytokine secretion and/or proliferation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01489488", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2372218", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092207", 
        "issn": [
          "0271-9142", 
          "1573-2592"
        ], 
        "name": "Journal of Clinical Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Interferon-\u03b1 activates cytotoxic function but inhibits interleukin-2-mediated proliferation and tumor necrosis factor-\u03b1 secretion by immature human natural killer cells", 
    "pagination": "35-44", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7a03947600edd32f4322353b5e1a0f77a713317ed5a857f2140c5163685bc043"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7759599"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8102137"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01489488"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025611527"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01489488", 
      "https://app.dimensions.ai/details/publication/pub.1025611527"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46777_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF01489488"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01489488'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01489488'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01489488'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01489488'


 

This table displays all metadata directly associated to this object as RDF triples.

203 TRIPLES      21 PREDICATES      67 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01489488 schema:about N18149fecd5434bce8592f8b2b5ecb044
2 N3990e94099e543369d9a21d7a18ffe02
3 N3ee53e69d8dd4166a381ede17f2bda67
4 N4ddef3a8772540dca0772e420205acd9
5 N612d0bc4729b48d59b6ead577f9c2a2f
6 N6e1e7571e1a944ac86fb83066a1bffa7
7 N7f9557a6cb414b4c85d900ed008f3ea1
8 Na2d38ac79ae34af6ad096ba38915f152
9 Nae076b1dca2446e2855231050cbaf114
10 Nbfe55a1197dc48daa161c6af966c86e7
11 Ncdddea5719ca42e1a53c68b51d32a7d9
12 Nd05bfc52a40c4e978d4b8bce7a0bdbf5
13 Nf4ceafa7e6a84e5da6ed916eedc6b3b5
14 Nf89ca914ca8d4346b5017379d743701d
15 anzsrc-for:11
16 anzsrc-for:1107
17 schema:author N56aed98d96aa4fabb4d1ffaa8aa51104
18 schema:citation sg:pub.10.1007/bf00047471
19 sg:pub.10.1007/bf01665006
20 sg:pub.10.1007/bf01741057
21 https://app.dimensions.ai/details/publication/pub.1078904247
22 https://app.dimensions.ai/details/publication/pub.1079571146
23 https://app.dimensions.ai/details/publication/pub.1079647824
24 https://app.dimensions.ai/details/publication/pub.1081593731
25 https://app.dimensions.ai/details/publication/pub.1082463962
26 https://app.dimensions.ai/details/publication/pub.1082798253
27 https://doi.org/10.1002/1097-0142(19920515)69:10<2525::aid-cncr2820691023>3.0.co;2-d
28 https://doi.org/10.1002/eji.1830191021
29 https://doi.org/10.1002/eji.1830210726
30 https://doi.org/10.1002/ijc.2910480328
31 https://doi.org/10.1006/cimm.1993.1236
32 https://doi.org/10.1016/0008-8749(90)90261-o
33 https://doi.org/10.1016/0090-1229(89)90120-7
34 https://doi.org/10.1042/bj2260345
35 https://doi.org/10.1073/pnas.83.7.2061
36 https://doi.org/10.1073/pnas.87.16.6063
37 https://doi.org/10.1084/jem.163.6.1405
38 https://doi.org/10.1084/jem.171.3.745
39 https://doi.org/10.1084/jem.172.6.1729
40 https://doi.org/10.1084/jem.175.3.779
41 https://doi.org/10.1111/j.1432-1033.1990.tb15478.x
42 schema:datePublished 1995-01
43 schema:datePublishedReg 1995-01-01
44 schema:description Natural killer (NK) cells play an important role in host defense mechanisms against infection and neoplasia. Interferon-alpha (IFN-alpha) has been shown to activate NK cells and to augment their cytotoxic activity, albeit its role in the maturation pathway of NK cells has not been elucidated. The present study examined whether IFN-alpha activates the immature NK subset (Free cells) to become cytotoxic and also ascertained whether IFN-alpha uses the same pathway of activation as that mediated by interleukin-2 (IL-2). Incubation of sorted Free cells overnight with IFN-alpha resulted in augmentation of their cytotoxic function against NK sensitive target cells. The enhanced cytotoxic activity was not accompanied by a new recruitment of NK-target binder cells but by an increase in the frequency of killer cells in the conjugate fraction. Activation of the Free subset by IFN-alpha resulted in upregulation of CD69, CD11b, and CD2 surface expression and stimulated secretion of IFN-gamma. Unlike IL-2, IFN-alpha did not stimulate the Free cells to proliferate or secrete TNF-alpha and activation of cytotoxicity and modulation of surface antigens by IFN-alpha were independent of TNF-alpha. The failure of IFN-alpha to stimulate secretion and proliferation by Free cells appeared to be mediated by negative signals. This was corroborated in experiments demonstrating that when Free cells were cultured with both IFN-alpha and IL-2, a significant inhibition was observed for both the IL-2 dependent secretion of TNF-alpha and proliferation. These results demonstrate that IFN-alpha serves as both an activator and a regulator of NK function. Further, activation of the immature Free NK cells by IL-2 and IFN-alpha proceeds by TNF-alpha- dependent and independent pathways, respectively. The findings also support our contention that the mechanism of activation of the cytotoxic machinery of NK cells is not linked to the mechanism of activation of cytokine secretion and/or proliferation.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N486112e541a84d4d9cb48c018c8a8071
49 Nfa0c284738c24927ad698522e8d22352
50 sg:journal.1092207
51 schema:name Interferon-α activates cytotoxic function but inhibits interleukin-2-mediated proliferation and tumor necrosis factor-α secretion by immature human natural killer cells
52 schema:pagination 35-44
53 schema:productId N072e8c3f989849cf803f3d6444afed6e
54 N1bccc759b8084d6eb3b107015f860bd7
55 N35bd3cfef6b642488b4d2124f57e00ca
56 N38e96d7952a844b3894e247b966cc780
57 N5fdecf74161744c5aeeda226e498a121
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025611527
59 https://doi.org/10.1007/bf01489488
60 schema:sdDatePublished 2019-04-11T13:36
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N729f310f4eaf4860b28315dbbe6a14ca
63 schema:url http://link.springer.com/10.1007/BF01489488
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N072e8c3f989849cf803f3d6444afed6e schema:name pubmed_id
68 schema:value 7759599
69 rdf:type schema:PropertyValue
70 N18149fecd5434bce8592f8b2b5ecb044 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Interferon Type I
72 rdf:type schema:DefinedTerm
73 N1bccc759b8084d6eb3b107015f860bd7 schema:name doi
74 schema:value 10.1007/bf01489488
75 rdf:type schema:PropertyValue
76 N35bd3cfef6b642488b4d2124f57e00ca schema:name readcube_id
77 schema:value 7a03947600edd32f4322353b5e1a0f77a713317ed5a857f2140c5163685bc043
78 rdf:type schema:PropertyValue
79 N38e96d7952a844b3894e247b966cc780 schema:name dimensions_id
80 schema:value pub.1025611527
81 rdf:type schema:PropertyValue
82 N3990e94099e543369d9a21d7a18ffe02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Killer Cells, Natural
84 rdf:type schema:DefinedTerm
85 N3ee53e69d8dd4166a381ede17f2bda67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Humans
87 rdf:type schema:DefinedTerm
88 N486112e541a84d4d9cb48c018c8a8071 schema:volumeNumber 15
89 rdf:type schema:PublicationVolume
90 N4ddef3a8772540dca0772e420205acd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Up-Regulation
92 rdf:type schema:DefinedTerm
93 N56aed98d96aa4fabb4d1ffaa8aa51104 rdf:first sg:person.0602347273.91
94 rdf:rest Na18251f808eb4175bcbe68a7ca802f94
95 N5fdecf74161744c5aeeda226e498a121 schema:name nlm_unique_id
96 schema:value 8102137
97 rdf:type schema:PropertyValue
98 N612d0bc4729b48d59b6ead577f9c2a2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Antigens, CD
100 rdf:type schema:DefinedTerm
101 N6e1e7571e1a944ac86fb83066a1bffa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Tumor Cells, Cultured
103 rdf:type schema:DefinedTerm
104 N729f310f4eaf4860b28315dbbe6a14ca schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N7f9557a6cb414b4c85d900ed008f3ea1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Enzyme-Linked Immunosorbent Assay
108 rdf:type schema:DefinedTerm
109 Na18251f808eb4175bcbe68a7ca802f94 rdf:first sg:person.014442031637.81
110 rdf:rest rdf:nil
111 Na2d38ac79ae34af6ad096ba38915f152 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Recombinant Proteins
113 rdf:type schema:DefinedTerm
114 Nae076b1dca2446e2855231050cbaf114 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cytotoxicity, Immunologic
116 rdf:type schema:DefinedTerm
117 Nbfe55a1197dc48daa161c6af966c86e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Lymphocyte Activation
119 rdf:type schema:DefinedTerm
120 Ncdddea5719ca42e1a53c68b51d32a7d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Flow Cytometry
122 rdf:type schema:DefinedTerm
123 Nd05bfc52a40c4e978d4b8bce7a0bdbf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Tumor Necrosis Factor-alpha
125 rdf:type schema:DefinedTerm
126 Nf4ceafa7e6a84e5da6ed916eedc6b3b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Interleukin-2
128 rdf:type schema:DefinedTerm
129 Nf89ca914ca8d4346b5017379d743701d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cells, Cultured
131 rdf:type schema:DefinedTerm
132 Nfa0c284738c24927ad698522e8d22352 schema:issueNumber 1
133 rdf:type schema:PublicationIssue
134 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
135 schema:name Medical and Health Sciences
136 rdf:type schema:DefinedTerm
137 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
138 schema:name Immunology
139 rdf:type schema:DefinedTerm
140 sg:grant.2372218 http://pending.schema.org/fundedItem sg:pub.10.1007/bf01489488
141 rdf:type schema:MonetaryGrant
142 sg:journal.1092207 schema:issn 0271-9142
143 1573-2592
144 schema:name Journal of Clinical Immunology
145 rdf:type schema:Periodical
146 sg:person.014442031637.81 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
147 schema:familyName Bonavida
148 schema:givenName Benjamin
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014442031637.81
150 rdf:type schema:Person
151 sg:person.0602347273.91 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
152 schema:familyName Jewett
153 schema:givenName Anahid
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602347273.91
155 rdf:type schema:Person
156 sg:pub.10.1007/bf00047471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046220680
157 https://doi.org/10.1007/bf00047471
158 rdf:type schema:CreativeWork
159 sg:pub.10.1007/bf01665006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048789018
160 https://doi.org/10.1007/bf01665006
161 rdf:type schema:CreativeWork
162 sg:pub.10.1007/bf01741057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037437629
163 https://doi.org/10.1007/bf01741057
164 rdf:type schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1078904247 schema:CreativeWork
166 https://app.dimensions.ai/details/publication/pub.1079571146 schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1079647824 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1081593731 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1082463962 schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1082798253 schema:CreativeWork
171 https://doi.org/10.1002/1097-0142(19920515)69:10<2525::aid-cncr2820691023>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1028100917
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1002/eji.1830191021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001659221
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1002/eji.1830210726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015873598
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1002/ijc.2910480328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010384559
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1006/cimm.1993.1236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033788717
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0008-8749(90)90261-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1047554930
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/0090-1229(89)90120-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006273651
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1042/bj2260345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009915125
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1073/pnas.83.7.2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014129521
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1073/pnas.87.16.6063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038900333
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1084/jem.163.6.1405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052932086
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1084/jem.171.3.745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044223310
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1084/jem.172.6.1729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035169974
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1084/jem.175.3.779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004613294
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1111/j.1432-1033.1990.tb15478.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003745809
200 rdf:type schema:CreativeWork
201 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
202 schema:name Department of Microbiology and Immunology, UCLA School of Medicine, University of California at Los Angeles, 90024, California
203 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...