Effects of fenfluramine on autistic individuals residing in a state developmental center View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-09

AUTHORS

Elsie Yarbrough, Udom Santat, Israel Perel, Cynthia Webster, Rebecca Lombardi

ABSTRACT

The effects of fenfluramine on 21 maladaptive behaviors in 20 autistic individuals were examined over a 9-month period utilizing a double-blind, cross-over, placebo-controlled design. Raters carried out time-sampled observations in the school and residence. In addition, videotaped data were collected in controlled settings and assessed by the raters at the conclusion of the study. Some individuals displayed negative side effects such as tension, agitation, insomnia, and sweating during the 16-week period they received fenfluramine. The results demonstrated that fenfluramine caused no significant reductions in maladaptive behaviors. The lack of any significant positive results from this medication and the side effects observed strongly indicate the need for caution in the use of fenfluramine with autistic persons. More... »

PAGES

303-314

References to SciGraph publications

  • 1971-06. Effects of L-dopa in autism in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1986-06. Brief report: The effects of fenfluramine on communication skills in autistic children in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1985-03. Brief report: Effects of fenfluramine on behavioral, cognitive, and affective disturbances in autistic children in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1985-12. Brief report: Clinical effects of fenfluramine in ten autistic subjects in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01487062

    DOI

    http://dx.doi.org/10.1007/bf01487062

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029131168

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3308829


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