Fenfluramine treatment of autism: Relationship of treatment response to blood levels of fenfluramine and norfenfluramine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-12

AUTHORS

James H. L. Beeghly, Samuel Kuperman, Paul J. Perry, George J. Wright, Luke Y. Tsai

ABSTRACT

Nine children meeting DSM-III criteria for infantile autism were treated with fenfluramine hydrochloride or inactive placebo in a double-blind crossover trial that followed the protocol for the fenfluramine multicenter study. Parents of the two children who had had the highest fenfluramine blood levels wished to have their children continue on fenfluramine, although the improvement they saw could not be demonstrated on the various rating instruments employed. The results of the study, while providing minimal support in themselves for the effectiveness of fenfluramine, do raise the possibility that fenfluramine blood levels might be related to treatment response. More... »

PAGES

541-548

References to SciGraph publications

  • 1976-12. Reassessment of elevated serotonin levels in blood platelets in early infantile autism in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1986-06. Brief report: The effects of fenfluramine on communication skills in autistic children in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1985-12. Brief report: Clinical effects of fenfluramine in ten autistic subjects in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01486969

    DOI

    http://dx.doi.org/10.1007/bf01486969

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030853143

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3316172


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