Zur Frage der Knochenmarksschädigung durch cancerotoxische Substanzen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1960-01

AUTHORS

Norbert Brock, Hans-Jürgen Hohorst

ABSTRACT

An Ratten mit Jensen-Sarkom wurde der Einfluß von Cyclophosphamid und Äthyleniminobenzochinon auf den DPN-Gehalt von Tumor und Knochenmark geprüft. Bei Dosen mit vergleichbarer leukocytensenkender Wirkung sank der DPN-Gehalt im Tumor im Verlauf von 8 Tagen bei beiden Substanzen um mehr als die Hälfte ab; eine Erniedrigung des DPN-Gehaltes im Knochenmark wurde dagegen nur nach Äthyleniminobenzochinon, nicht nach Cyclophosphamid beobachtet. Die Befunde werden als Hinweis für eine gesteigerte Selektivität der cancerctoxischen Wirkung von Cyclophosphamid angesehen. Wir danken Fräulein Gertrud Laucks herzlich für ihre Mitarbeit bei der Durchführung der Untersuchungen. More... »

PAGES

69-71

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01483611

DOI

http://dx.doi.org/10.1007/bf01483611

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035879975

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/13804570


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