Ontology type: schema:ScholarlyArticle
1960-01
AUTHORSNorbert Brock, Hans-Jürgen Hohorst
ABSTRACTAn Ratten mit Jensen-Sarkom wurde der Einfluß von Cyclophosphamid und Äthyleniminobenzochinon auf den DPN-Gehalt von Tumor und Knochenmark geprüft. Bei Dosen mit vergleichbarer leukocytensenkender Wirkung sank der DPN-Gehalt im Tumor im Verlauf von 8 Tagen bei beiden Substanzen um mehr als die Hälfte ab; eine Erniedrigung des DPN-Gehaltes im Knochenmark wurde dagegen nur nach Äthyleniminobenzochinon, nicht nach Cyclophosphamid beobachtet. Die Befunde werden als Hinweis für eine gesteigerte Selektivität der cancerctoxischen Wirkung von Cyclophosphamid angesehen. Wir danken Fräulein Gertrud Laucks herzlich für ihre Mitarbeit bei der Durchführung der Untersuchungen. More... »
PAGES69-71
http://scigraph.springernature.com/pub.10.1007/bf01483611
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