Die Bedeutung der Bestimmung von Antikörpern gegen Acetylcholinreceptoren in der Diagnostik der Myasthenia gravis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-09

AUTHORS

K. V. Toyka, T. Becker, A. Fateh-Moghadam, U. A. Besinger, G. Brehm, D. Neumeier, K. Heininger, K. L. Birnberger

ABSTRACT

The sera of 65 patients with myasthenia gravis (MG) were analysed for antibodies against the nicotinic acetylcholine receptor (ACh-R) using an immunoprecipitation assay (125I-alpha-bungarotoxin bound to human ACh-R as antigen). In 91% of MG sera elevated antibody titers were found ranging up to 500 times reference values. A control group of 77 patients showing various autoimmunological phenomena had ACh-R antibody concentrations within the reference range. The demonstration of antibodies against ACh-R provides a sensitive and highly specific tool for the diagnosis of MG. In addition, the test is helpful in following patients under treatment with immunosuppressive drugs or plasmapheresis. Antibodies against striated, smooth, or heart muscle (indirect immunofluorescence test) are much less sensitive and nonspecific for the diagnosis of MG. More... »

PAGES

937-942

References to SciGraph publications

  • 1978-02. Myasthene Syndrome unter Penicillamin-Therapie in JOURNAL OF MOLECULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01478550

    DOI

    http://dx.doi.org/10.1007/bf01478550

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026803580

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/502359


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