Intrathecal injection of autologous leucocytes in glioblastoma: Circulatory dynamics within the subarachnoid space and clinical results View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-03

AUTHORS

J. Vaquero, R. Martínez, L. Barbolla, J. de Haro, S. de Oya, S. Coca, J. Ramiro

ABSTRACT

In part I of this report, the CSF circulatory dynamics of autologous leucocytes labelled with indium-111 and injected in the subarachnoid space, in patients operated on for glioblastoma, were studied. In the Part II, a series of 11 patients with recurrent glioblastoma was studied for evaluating the efficacy of intrathecal injection of autologous leucocytes. Six patients previously had radiotherapy. The results in Part I show that after intrathecal injection of autologous leucocytes, these cells follow throughout the subarachnoid space and pass to the systemic blood circulation, showing no evidence of colonization of the tumour or deposit in the tumoural region. The mean survival of the patients studied in Part II was 8 months. Those six patients who received radiotherapy had a mean survival of 11.4 months, and those five who received only intrathecal injection of autologous leucocytes after surgery, had a mean survival of 4 months. This results seem to demonstrate that immunotherapy, as used in this study, is ineffective in patients with glioblastoma. More... »

PAGES

37-42

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01406665

DOI

http://dx.doi.org/10.1007/bf01406665

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028746349

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3434340


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebrospinal Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indium Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Spinal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Subarachnoid Space", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital de Madrid", 
          "id": "https://www.grid.ac/institutes/grid.411171.3", 
          "name": [
            "Departments of Neurosurgery, Haematology and Nuclear Medicine, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain", 
            "Department of Morphology, Complutensis University, Madrid, Spain", 
            "Department of Neurosurgery, Hospital Provincial, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaquero", 
        "givenName": "J.", 
        "id": "sg:person.01047427763.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047427763.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Madrid", 
          "id": "https://www.grid.ac/institutes/grid.411171.3", 
          "name": [
            "Departments of Neurosurgery, Haematology and Nuclear Medicine, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain", 
            "Department of Morphology, Complutensis University, Madrid, Spain", 
            "Department of Neurosurgery, Hospital Provincial, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez", 
        "givenName": "R.", 
        "id": "sg:person.0631313213.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631313213.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Madrid", 
          "id": "https://www.grid.ac/institutes/grid.411171.3", 
          "name": [
            "Departments of Neurosurgery, Haematology and Nuclear Medicine, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain", 
            "Department of Morphology, Complutensis University, Madrid, Spain", 
            "Department of Neurosurgery, Hospital Provincial, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbolla", 
        "givenName": "L.", 
        "id": "sg:person.01337153261.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337153261.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Madrid", 
          "id": "https://www.grid.ac/institutes/grid.411171.3", 
          "name": [
            "Departments of Neurosurgery, Haematology and Nuclear Medicine, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain", 
            "Department of Morphology, Complutensis University, Madrid, Spain", 
            "Department of Neurosurgery, Hospital Provincial, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Haro", 
        "givenName": "J.", 
        "id": "sg:person.01064236132.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064236132.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Madrid", 
          "id": "https://www.grid.ac/institutes/grid.411171.3", 
          "name": [
            "Departments of Neurosurgery, Haematology and Nuclear Medicine, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain", 
            "Department of Morphology, Complutensis University, Madrid, Spain", 
            "Department of Neurosurgery, Hospital Provincial, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Oya", 
        "givenName": "S.", 
        "id": "sg:person.01013655013.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013655013.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Madrid", 
          "id": "https://www.grid.ac/institutes/grid.411171.3", 
          "name": [
            "Departments of Neurosurgery, Haematology and Nuclear Medicine, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain", 
            "Department of Morphology, Complutensis University, Madrid, Spain", 
            "Department of Neurosurgery, Hospital Provincial, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coca", 
        "givenName": "S.", 
        "id": "sg:person.01343300324.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343300324.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Madrid", 
          "id": "https://www.grid.ac/institutes/grid.411171.3", 
          "name": [
            "Departments of Neurosurgery, Haematology and Nuclear Medicine, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain", 
            "Department of Morphology, Complutensis University, Madrid, Spain", 
            "Department of Neurosurgery, Hospital Provincial, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramiro", 
        "givenName": "J.", 
        "id": "sg:person.01130103413.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130103413.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01405238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009774216", 
          "https://doi.org/10.1007/bf01405238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800680304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012765930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910120120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017582040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410040404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020023035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000119563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024376766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(60)91219-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027710107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(60)91219-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027710107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197709)40:3<1037::aid-cncr2820400311>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031800718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410040305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036542683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-009-6027-5_33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042639236", 
          "https://doi.org/10.1007/978-94-009-6027-5_33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-3019(85)90086-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051759432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/94.1.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059444310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.11.11.977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064358366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.15.5.474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064359267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.22.3.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064360800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1969.31.3.0339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071089154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1969.31.3.0339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071089154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1969.31.3.0339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071089154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1977.47.2.0205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1977.47.2.0205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1977.47.2.0205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1978.49.3.0333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1978.49.3.0333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1978.49.3.0333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1978.49.6.0854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1978.49.6.0854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1978.49.6.0854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071091663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1984.61.6.1069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071093808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1984.61.6.1069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071093808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1984.61.6.1069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071093808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1985.63.5.0719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1985.63.5.0719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1985.63.5.0719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.1.0114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.1.0114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.1.0114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.3.0408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.3.0408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.3.0408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.5.0743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.5.0743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.5.0743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075917413", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077746436", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080129422", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080272249", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080300682", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080303467", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082510835", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jjco.a039811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083486913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000386082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1088685731"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1987-03", 
    "datePublishedReg": "1987-03-01", 
    "description": "In part I of this report, the CSF circulatory dynamics of autologous leucocytes labelled with indium-111 and injected in the subarachnoid space, in patients operated on for glioblastoma, were studied. In the Part II, a series of 11 patients with recurrent glioblastoma was studied for evaluating the efficacy of intrathecal injection of autologous leucocytes. Six patients previously had radiotherapy. The results in Part I show that after intrathecal injection of autologous leucocytes, these cells follow throughout the subarachnoid space and pass to the systemic blood circulation, showing no evidence of colonization of the tumour or deposit in the tumoural region. The mean survival of the patients studied in Part II was 8 months. Those six patients who received radiotherapy had a mean survival of 11.4 months, and those five who received only intrathecal injection of autologous leucocytes after surgery, had a mean survival of 4 months. This results seem to demonstrate that immunotherapy, as used in this study, is ineffective in patients with glioblastoma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01406665", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1356888", 
        "issn": [
          "0001-6268", 
          "0942-0940"
        ], 
        "name": "Acta Neurochirurgica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "89"
      }
    ], 
    "name": "Intrathecal injection of autologous leucocytes in glioblastoma: Circulatory dynamics within the subarachnoid space and clinical results", 
    "pagination": "37-42", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "88f07c2657fae20931feaa5610cae127d02eac18b383344897bd572480b7cfaa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3434340"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0151000"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01406665"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028746349"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01406665", 
      "https://app.dimensions.ai/details/publication/pub.1028746349"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000532.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF01406665"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01406665'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01406665'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01406665'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01406665'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      21 PREDICATES      76 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01406665 schema:about N0571af6fd69e4ef2926e6d73ff27d898
2 N2dd39b8e9b7646e8be7b5df628fc0a6c
3 N35f31fee09494f62a2cffc682ba2390c
4 N545e65966b7a4dfbb89710814133e154
5 N5848c916b784493d83e0ddb9a9f06615
6 N75cb2fb865d1497baff6b6a129229288
7 N7fc53c306c244b9b9acbfffe47888ca9
8 Na173753ad6374039b7ef499371dd6108
9 Nab142f7d3e8242ba8bbbea7412677c84
10 Nca009837e3c74af39023eb6e9b19c256
11 Nce4ef005ff8f4db8a2acc161c1056b8e
12 Ncf8e7f7e6ed641ee9ec2aaeacd67f6eb
13 Nd324c70759ab416baa15b0a28a1666fb
14 Nf2c091a1af644163ba1c565df44d799b
15 Nf3b977f297844a09ae7e36d3f57fa727
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N9ce929e69f5e4f858856fb9a6b45fbfc
19 schema:citation sg:pub.10.1007/978-94-009-6027-5_33
20 sg:pub.10.1007/bf01405238
21 https://app.dimensions.ai/details/publication/pub.1075917413
22 https://app.dimensions.ai/details/publication/pub.1077746436
23 https://app.dimensions.ai/details/publication/pub.1080129422
24 https://app.dimensions.ai/details/publication/pub.1080272249
25 https://app.dimensions.ai/details/publication/pub.1080300682
26 https://app.dimensions.ai/details/publication/pub.1080303467
27 https://app.dimensions.ai/details/publication/pub.1082510835
28 https://doi.org/10.1002/1097-0142(197709)40:3<1037::aid-cncr2820400311>3.0.co;2-9
29 https://doi.org/10.1002/ana.410040305
30 https://doi.org/10.1002/ana.410040404
31 https://doi.org/10.1002/bjs.1800680304
32 https://doi.org/10.1002/ijc.2910120120
33 https://doi.org/10.1016/0090-3019(85)90086-2
34 https://doi.org/10.1016/s0140-6736(60)91219-8
35 https://doi.org/10.1093/brain/94.1.117
36 https://doi.org/10.1093/oxfordjournals.jjco.a039811
37 https://doi.org/10.1159/000119563
38 https://doi.org/10.1159/000386082
39 https://doi.org/10.1212/wnl.11.11.977
40 https://doi.org/10.1212/wnl.15.5.474
41 https://doi.org/10.1212/wnl.22.3.246
42 https://doi.org/10.3171/jns.1969.31.3.0339
43 https://doi.org/10.3171/jns.1977.47.2.0205
44 https://doi.org/10.3171/jns.1978.49.3.0333
45 https://doi.org/10.3171/jns.1978.49.6.0854
46 https://doi.org/10.3171/jns.1984.61.6.1069
47 https://doi.org/10.3171/jns.1985.63.5.0719
48 https://doi.org/10.3171/jns.1986.64.1.0114
49 https://doi.org/10.3171/jns.1986.64.3.0408
50 https://doi.org/10.3171/jns.1986.64.5.0743
51 schema:datePublished 1987-03
52 schema:datePublishedReg 1987-03-01
53 schema:description In part I of this report, the CSF circulatory dynamics of autologous leucocytes labelled with indium-111 and injected in the subarachnoid space, in patients operated on for glioblastoma, were studied. In the Part II, a series of 11 patients with recurrent glioblastoma was studied for evaluating the efficacy of intrathecal injection of autologous leucocytes. Six patients previously had radiotherapy. The results in Part I show that after intrathecal injection of autologous leucocytes, these cells follow throughout the subarachnoid space and pass to the systemic blood circulation, showing no evidence of colonization of the tumour or deposit in the tumoural region. The mean survival of the patients studied in Part II was 8 months. Those six patients who received radiotherapy had a mean survival of 11.4 months, and those five who received only intrathecal injection of autologous leucocytes after surgery, had a mean survival of 4 months. This results seem to demonstrate that immunotherapy, as used in this study, is ineffective in patients with glioblastoma.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf Nca0cc46486cc436bbda5bd39d85e3cb4
58 Ncc8fd5e6c657446691697cf110a95047
59 sg:journal.1356888
60 schema:name Intrathecal injection of autologous leucocytes in glioblastoma: Circulatory dynamics within the subarachnoid space and clinical results
61 schema:pagination 37-42
62 schema:productId N064b1c3d3fbf42ddbf26aa08841412f2
63 N1d03110b477447c1a0e8b3b854a02637
64 N2cbea7656ab248b3925d3714e166620d
65 N4d30481e547c4c5e93b8048d05738760
66 Nb0af30ad187b4ac2863829fe1a5da528
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028746349
68 https://doi.org/10.1007/bf01406665
69 schema:sdDatePublished 2019-04-11T02:14
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N0e4d8e9e560441159d99a16a87b49ede
72 schema:url http://link.springer.com/10.1007%2FBF01406665
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0398e52009854c63a591d3c50590cbcc rdf:first sg:person.0631313213.62
77 rdf:rest N1840c5556ca343aeab6f809b6293effa
78 N0571af6fd69e4ef2926e6d73ff27d898 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Injections, Spinal
80 rdf:type schema:DefinedTerm
81 N064b1c3d3fbf42ddbf26aa08841412f2 schema:name pubmed_id
82 schema:value 3434340
83 rdf:type schema:PropertyValue
84 N0e4d8e9e560441159d99a16a87b49ede schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N176776c8a4f54be3a9c7269686ba3bd1 rdf:first sg:person.01343300324.81
87 rdf:rest N1b3bc3d50f5f4585910e8cd013e62519
88 N1840c5556ca343aeab6f809b6293effa rdf:first sg:person.01337153261.06
89 rdf:rest N202fcd56087447e29bcab08eec9f8613
90 N1b3bc3d50f5f4585910e8cd013e62519 rdf:first sg:person.01130103413.13
91 rdf:rest rdf:nil
92 N1d03110b477447c1a0e8b3b854a02637 schema:name nlm_unique_id
93 schema:value 0151000
94 rdf:type schema:PropertyValue
95 N202fcd56087447e29bcab08eec9f8613 rdf:first sg:person.01064236132.05
96 rdf:rest Nc6a3e1fc344c486faa5501744830d35a
97 N2cbea7656ab248b3925d3714e166620d schema:name dimensions_id
98 schema:value pub.1028746349
99 rdf:type schema:PropertyValue
100 N2dd39b8e9b7646e8be7b5df628fc0a6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Glioma
102 rdf:type schema:DefinedTerm
103 N35f31fee09494f62a2cffc682ba2390c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Leukocytes
105 rdf:type schema:DefinedTerm
106 N4d30481e547c4c5e93b8048d05738760 schema:name doi
107 schema:value 10.1007/bf01406665
108 rdf:type schema:PropertyValue
109 N545e65966b7a4dfbb89710814133e154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Indium Radioisotopes
111 rdf:type schema:DefinedTerm
112 N5848c916b784493d83e0ddb9a9f06615 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Immunotherapy
114 rdf:type schema:DefinedTerm
115 N75cb2fb865d1497baff6b6a129229288 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Male
117 rdf:type schema:DefinedTerm
118 N7fc53c306c244b9b9acbfffe47888ca9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 N9ce929e69f5e4f858856fb9a6b45fbfc rdf:first sg:person.01047427763.51
122 rdf:rest N0398e52009854c63a591d3c50590cbcc
123 Na173753ad6374039b7ef499371dd6108 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Brain Neoplasms
125 rdf:type schema:DefinedTerm
126 Nab142f7d3e8242ba8bbbea7412677c84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Tomography, X-Ray Computed
128 rdf:type schema:DefinedTerm
129 Nb0af30ad187b4ac2863829fe1a5da528 schema:name readcube_id
130 schema:value 88f07c2657fae20931feaa5610cae127d02eac18b383344897bd572480b7cfaa
131 rdf:type schema:PropertyValue
132 Nc6a3e1fc344c486faa5501744830d35a rdf:first sg:person.01013655013.51
133 rdf:rest N176776c8a4f54be3a9c7269686ba3bd1
134 Nca009837e3c74af39023eb6e9b19c256 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Aged
136 rdf:type schema:DefinedTerm
137 Nca0cc46486cc436bbda5bd39d85e3cb4 schema:volumeNumber 89
138 rdf:type schema:PublicationVolume
139 Ncc8fd5e6c657446691697cf110a95047 schema:issueNumber 1-2
140 rdf:type schema:PublicationIssue
141 Nce4ef005ff8f4db8a2acc161c1056b8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Middle Aged
143 rdf:type schema:DefinedTerm
144 Ncf8e7f7e6ed641ee9ec2aaeacd67f6eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 Nd324c70759ab416baa15b0a28a1666fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adult
149 rdf:type schema:DefinedTerm
150 Nf2c091a1af644163ba1c565df44d799b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cerebrospinal Fluid
152 rdf:type schema:DefinedTerm
153 Nf3b977f297844a09ae7e36d3f57fa727 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Subarachnoid Space
155 rdf:type schema:DefinedTerm
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
160 schema:name Oncology and Carcinogenesis
161 rdf:type schema:DefinedTerm
162 sg:journal.1356888 schema:issn 0001-6268
163 0942-0940
164 schema:name Acta Neurochirurgica
165 rdf:type schema:Periodical
166 sg:person.01013655013.51 schema:affiliation https://www.grid.ac/institutes/grid.411171.3
167 schema:familyName de Oya
168 schema:givenName S.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013655013.51
170 rdf:type schema:Person
171 sg:person.01047427763.51 schema:affiliation https://www.grid.ac/institutes/grid.411171.3
172 schema:familyName Vaquero
173 schema:givenName J.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047427763.51
175 rdf:type schema:Person
176 sg:person.01064236132.05 schema:affiliation https://www.grid.ac/institutes/grid.411171.3
177 schema:familyName de Haro
178 schema:givenName J.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064236132.05
180 rdf:type schema:Person
181 sg:person.01130103413.13 schema:affiliation https://www.grid.ac/institutes/grid.411171.3
182 schema:familyName Ramiro
183 schema:givenName J.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130103413.13
185 rdf:type schema:Person
186 sg:person.01337153261.06 schema:affiliation https://www.grid.ac/institutes/grid.411171.3
187 schema:familyName Barbolla
188 schema:givenName L.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337153261.06
190 rdf:type schema:Person
191 sg:person.01343300324.81 schema:affiliation https://www.grid.ac/institutes/grid.411171.3
192 schema:familyName Coca
193 schema:givenName S.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343300324.81
195 rdf:type schema:Person
196 sg:person.0631313213.62 schema:affiliation https://www.grid.ac/institutes/grid.411171.3
197 schema:familyName Martínez
198 schema:givenName R.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631313213.62
200 rdf:type schema:Person
201 sg:pub.10.1007/978-94-009-6027-5_33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042639236
202 https://doi.org/10.1007/978-94-009-6027-5_33
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/bf01405238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009774216
205 https://doi.org/10.1007/bf01405238
206 rdf:type schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1075917413 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1077746436 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1080129422 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1080272249 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1080300682 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1080303467 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1082510835 schema:CreativeWork
214 https://doi.org/10.1002/1097-0142(197709)40:3<1037::aid-cncr2820400311>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031800718
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/ana.410040305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036542683
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/ana.410040404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020023035
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/bjs.1800680304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012765930
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/ijc.2910120120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017582040
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/0090-3019(85)90086-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051759432
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0140-6736(60)91219-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027710107
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1093/brain/94.1.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059444310
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1093/oxfordjournals.jjco.a039811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083486913
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1159/000119563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024376766
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1159/000386082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088685731
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1212/wnl.11.11.977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064358366
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1212/wnl.15.5.474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064359267
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1212/wnl.22.3.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064360800
241 rdf:type schema:CreativeWork
242 https://doi.org/10.3171/jns.1969.31.3.0339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071089154
243 rdf:type schema:CreativeWork
244 https://doi.org/10.3171/jns.1977.47.2.0205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071091236
245 rdf:type schema:CreativeWork
246 https://doi.org/10.3171/jns.1978.49.3.0333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071091575
247 rdf:type schema:CreativeWork
248 https://doi.org/10.3171/jns.1978.49.6.0854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071091663
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3171/jns.1984.61.6.1069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071093808
251 rdf:type schema:CreativeWork
252 https://doi.org/10.3171/jns.1985.63.5.0719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071094137
253 rdf:type schema:CreativeWork
254 https://doi.org/10.3171/jns.1986.64.1.0114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071094211
255 rdf:type schema:CreativeWork
256 https://doi.org/10.3171/jns.1986.64.3.0408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071094264
257 rdf:type schema:CreativeWork
258 https://doi.org/10.3171/jns.1986.64.5.0743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071094322
259 rdf:type schema:CreativeWork
260 https://www.grid.ac/institutes/grid.411171.3 schema:alternateName Hospital de Madrid
261 schema:name Department of Morphology, Complutensis University, Madrid, Spain
262 Department of Neurosurgery, Hospital Provincial, Madrid, Spain
263 Departments of Neurosurgery, Haematology and Nuclear Medicine, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...