Influence of manganese on enzyme synthesis and citric acid accumulation inAspergillus niger View Full Text


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Article Info

DATE

1977-09

AUTHORS

C. P. Kubicek, M. Röhr

ABSTRACT

A comparison of citric acid fermentations in manganese-deficient and manganese-containing media showed that manganese strongly influences idiophase metabolism. In the presence of manganese, cell growth increases, sugar consumption is diminished and acidogenesis decreases drastically. An investigation of the key enzymes of glycolysis, the pentosephosphate pathway, TCA-cycle, nitrogen metabolism, and gluconeogenesis indicated that manganese deficiency was accompanied by a repression of anabolic and TCA-cycle-enzymes with the exception of citrate synthase. The activity of this enzyme and the enzymes of glycolysis paralleled the sugar consumption rate. In the presence of manganese, no repression of enzyme synthesis was observed. Activities of 2-oxoglutarate dehydrogenase and isocitrate lyase could not be detected in either case. The results support the hypothesis that manganese deficiency mainly affects the operation of biosynthetic reactions inAspergillus niger, thus leading to an overflow of citric acid as an end product of glycolysis. More... »

PAGES

167-175

References to SciGraph publications

  • 1969-12. Studies on gluconate metabolism in Aspergillus niger in ARCHIVES OF MICROBIOLOGY
  • 1975-01. Sexual differentiation in Aspergillus nidulans in ARCHIVES OF MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01390476

    DOI

    http://dx.doi.org/10.1007/bf01390476

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006038330


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