In vitro and in vivo studies of three radiolabelled somatostatin analogues:123I-Octreotide (OCT),123I-Tyr-3-OCT and111In-TIRA-d-Phe-1-OCT View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-10

AUTHORS

Irene Virgolini, Peter Angelberger, Shuren Li, Qiong Yang, Amir Kurtaran, Markus Raderer, Nikolaus Neuhold, Klaus Kaserer, Maria Leimer, Markus Peck-Radosavljevic, Werner Scheithauer, Bruno Niederle, Hans-Georg Eichler, Peter Valent

ABSTRACT

Scintigraphy with long-acting somatostatin (SST) analogues may be useful for the localization of tumours expressing receptors (R) for SST. In this study we have analysed the in vitro and in vivo binding properties of three SST analogues,123I-octreotide (OCT),123I-Tyr-3-OCT and111In-DTPA-d-Phe-l-OCT. In vitro binding studies performed with a variety of primary tumours (n=48) as well as with several tumour cell lines (A431, HT29, PANC1, COLO320, HMC1, KU812) indicated significant in vitro binding of these three radiolabelled SST analogues to two subpopulations of SSTR, high (Kd 0.2–2.0 nM) and low (Kd 5–15 nM) affinity ones. The number of SSTR on tumour cells was at least a 1000-fold higher as compared with normal peripheral blood cells. Comparative scintigraphic studies using123I-OCT and/or123I-Tyr-3-OCT and/or111In-DTPA-d-Phe-1-OCT were performed in 21 patients with histologically verified intestinal carcinoid tumours. Corresponding scintigraphic results were obtained in 18 of 21 patients investigated with two different SSTR ligands, either123I-OCT/123I-Tyr-3-OCT (four of five),123I-OCT/111In-DTPA-d-Phe-1-OCT (eight of nine), or123I-Tyr-3-OCT/111In-DTPA-d-Phe-1-OCT (six of seven). We conclude that various tumours express high amounts of SSTR which are recognized by three radiolabelled SST analogues:123I-OCT,123I-Tyr-3-OCT and111In-DTPA-d-Phe-1-OCT. Differences between these SST analogues in their in vitro binding and/or in vivo scanning properties are observed in a minority of patients. Thus, the labelling of OCT with iodine may be an alternative approach for those nuclear medicine departments for which111In-DTPA-d-Phe-1-OCT is not easily available, or is too expensive. More... »

PAGES

1388-1399

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01367597

DOI

http://dx.doi.org/10.1007/bf01367597

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044712964

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8781146


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoid Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indium Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Iodine Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Octreotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pentetic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radionuclide Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Somatostatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Ludwig Boltzmann Institute of Nuclear Medicine, University of Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria", 
            "Department of Clinical Pharmacology, University of Vienna, Austria", 
            "The Ludwig Boltzmann Institute of Nuclear Medicine, University of Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Virgolini", 
        "givenName": "Irene", 
        "id": "sg:person.0764224033.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764224033.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiochemistry, Research Center Seibersdorf, Austria", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Radiochemistry, Research Center Seibersdorf, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Angelberger", 
        "givenName": "Peter", 
        "id": "sg:person.067542523.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.067542523.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Shuren", 
        "id": "sg:person.0771074626.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771074626.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Qiong", 
        "id": "sg:person.01263066417.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263066417.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurtaran", 
        "givenName": "Amir", 
        "id": "sg:person.01355220604.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355220604.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Oncology, University of Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raderer", 
        "givenName": "Markus", 
        "id": "sg:person.01234601050.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234601050.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Pathology, University of Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neuhold", 
        "givenName": "Nikolaus", 
        "id": "sg:person.01311044454.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311044454.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Pathology, University of Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaserer", 
        "givenName": "Klaus", 
        "id": "sg:person.01046040764.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046040764.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Nuclear Medicine, University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leimer", 
        "givenName": "Maria", 
        "id": "sg:person.0644623102.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644623102.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, University of Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Gastroenterology, University of Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peck-Radosavljevic", 
        "givenName": "Markus", 
        "id": "sg:person.01046032607.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046032607.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiochemistry, Research Center Seibersdorf, Austria", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Radiochemistry, Research Center Seibersdorf, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scheithauer", 
        "givenName": "Werner", 
        "id": "sg:person.0713515512.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713515512.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Surgery, University of Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niederle", 
        "givenName": "Bruno", 
        "id": "sg:person.0671724636.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671724636.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pharmacology, University of Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Clinical Pharmacology, University of Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eichler", 
        "givenName": "Hans-Georg", 
        "id": "sg:person.014224752232.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014224752232.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, University of Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Hematology, University of Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valent", 
        "givenName": "Peter", 
        "id": "sg:person.0746740737.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746740737.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00181765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016946247", 
          "https://doi.org/10.1007/bf00181765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-011-3034-9_262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1089760933", 
          "https://doi.org/10.1007/978-94-011-3034-9_262"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-10", 
    "datePublishedReg": "1996-10-01", 
    "description": "Scintigraphy with long-acting somatostatin (SST) analogues may be useful for the localization of tumours expressing receptors (R) for SST. In this study we have analysed the in vitro and in vivo binding properties of three SST analogues,123I-octreotide (OCT),123I-Tyr-3-OCT and111In-DTPA-d-Phe-l-OCT. In vitro binding studies performed with a variety of primary tumours (n=48) as well as with several tumour cell lines (A431, HT29, PANC1, COLO320, HMC1, KU812) indicated significant in vitro binding of these three radiolabelled SST analogues to two subpopulations of SSTR, high (Kd 0.2\u20132.0 nM) and low (Kd 5\u201315 nM) affinity ones. The number of SSTR on tumour cells was at least a 1000-fold higher as compared with normal peripheral blood cells. Comparative scintigraphic studies using123I-OCT and/or123I-Tyr-3-OCT and/or111In-DTPA-d-Phe-1-OCT were performed in 21 patients with histologically verified intestinal carcinoid tumours. Corresponding scintigraphic results were obtained in 18 of 21 patients investigated with two different SSTR ligands, either123I-OCT/123I-Tyr-3-OCT (four of five),123I-OCT/111In-DTPA-d-Phe-1-OCT (eight of nine), or123I-Tyr-3-OCT/111In-DTPA-d-Phe-1-OCT (six of seven). We conclude that various tumours express high amounts of SSTR which are recognized by three radiolabelled SST analogues:123I-OCT,123I-Tyr-3-OCT and111In-DTPA-d-Phe-1-OCT. Differences between these SST analogues in their in vitro binding and/or in vivo scanning properties are observed in a minority of patients. Thus, the labelling of OCT with iodine may be an alternative approach for those nuclear medicine departments for which111In-DTPA-d-Phe-1-OCT is not easily available, or is too expensive.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01367597", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "DTPA-d-Phe", 
      "SST analogs", 
      "normal peripheral blood cells", 
      "radiolabelled SST analogues", 
      "minority of patients", 
      "intestinal carcinoid tumors", 
      "peripheral blood cells", 
      "localization of tumors", 
      "scintigraphic results", 
      "carcinoid tumors", 
      "nuclear medicine department", 
      "somatostatin analogues", 
      "primary tumor", 
      "medicine department", 
      "SSTR ligands", 
      "octreotide", 
      "D-Phe", 
      "tumor cell lines", 
      "tumors", 
      "tumor cells", 
      "patients", 
      "blood cells", 
      "vivo studies", 
      "SSTR", 
      "cell lines", 
      "low-affinity one", 
      "cells", 
      "somatostatin", 
      "receptors", 
      "study", 
      "subpopulations", 
      "vitro", 
      "vivo", 
      "Department", 
      "analogues", 
      "high amounts", 
      "differences", 
      "minority", 
      "labeling", 
      "localization", 
      "alternative approach", 
      "iodine", 
      "lines", 
      "number", 
      "ligands", 
      "results", 
      "variety", 
      "amount", 
      "approach", 
      "one", 
      "properties", 
      "SST", 
      "scanning properties"
    ], 
    "name": "In vitro and in vivo studies of three radiolabelled somatostatin analogues:123I-Octreotide (OCT),123I-Tyr-3-OCT and111In-TIRA-d-Phe-1-OCT", 
    "pagination": "1388-1399", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044712964"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01367597"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8781146"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01367597", 
      "https://app.dimensions.ai/details/publication/pub.1044712964"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T09:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_302.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01367597"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01367597'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01367597'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01367597'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01367597'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      22 PREDICATES      99 URIs      89 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01367597 schema:about N020ed2ee7cb64acca7dec1528d558022
2 N037a9220d1514199ad303777e7558b9d
3 N0b85817fc3fa410a8a65884808ba2e13
4 N2db5addcdf0a4bbd8e2c0be4a4e3c7e4
5 N3729fae034b6419fa712aeaa462c211e
6 N6138b68a59cf49209d7f901b6b38960a
7 N6577c17ce1244b66ad2b87de94a38460
8 N6c986714308640369ba10eab3ee8137f
9 N76dc7eb6746a4be0a74da88db25bbb48
10 N7fab78b6c4674010af45458dc2bb0bab
11 N838dfe42cce140b98456f77f8dbfc747
12 N96cd6370212f40c0955bad3fed27a4b7
13 Na0dc18b745084619ae26ce23264d7dca
14 Nbffa88753b264b9582fb48f7d18d6e34
15 Nc0610a8f1dfe4da4826fbb5a3cc88a91
16 Nf5fbe1ef8e3c4abf9d0f606011d697f2
17 Nf7478651ace842d0b5635762a1a07ae9
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N9079fc26a8cd4bceb2d1a08332e0f48c
21 schema:citation sg:pub.10.1007/978-94-011-3034-9_262
22 sg:pub.10.1007/bf00181765
23 schema:datePublished 1996-10
24 schema:datePublishedReg 1996-10-01
25 schema:description Scintigraphy with long-acting somatostatin (SST) analogues may be useful for the localization of tumours expressing receptors (R) for SST. In this study we have analysed the in vitro and in vivo binding properties of three SST analogues,123I-octreotide (OCT),123I-Tyr-3-OCT and111In-DTPA-d-Phe-l-OCT. In vitro binding studies performed with a variety of primary tumours (n=48) as well as with several tumour cell lines (A431, HT29, PANC1, COLO320, HMC1, KU812) indicated significant in vitro binding of these three radiolabelled SST analogues to two subpopulations of SSTR, high (Kd 0.2–2.0 nM) and low (Kd 5–15 nM) affinity ones. The number of SSTR on tumour cells was at least a 1000-fold higher as compared with normal peripheral blood cells. Comparative scintigraphic studies using123I-OCT and/or123I-Tyr-3-OCT and/or111In-DTPA-d-Phe-1-OCT were performed in 21 patients with histologically verified intestinal carcinoid tumours. Corresponding scintigraphic results were obtained in 18 of 21 patients investigated with two different SSTR ligands, either123I-OCT/123I-Tyr-3-OCT (four of five),123I-OCT/111In-DTPA-d-Phe-1-OCT (eight of nine), or123I-Tyr-3-OCT/111In-DTPA-d-Phe-1-OCT (six of seven). We conclude that various tumours express high amounts of SSTR which are recognized by three radiolabelled SST analogues:123I-OCT,123I-Tyr-3-OCT and111In-DTPA-d-Phe-1-OCT. Differences between these SST analogues in their in vitro binding and/or in vivo scanning properties are observed in a minority of patients. Thus, the labelling of OCT with iodine may be an alternative approach for those nuclear medicine departments for which111In-DTPA-d-Phe-1-OCT is not easily available, or is too expensive.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N208de3c538ba4c4e9bf255b9ac41a1ba
30 N3ebfb8bcb70b4e6e95a6914788f68dc6
31 sg:journal.1297401
32 schema:keywords D-Phe
33 DTPA-d-Phe
34 Department
35 SST
36 SST analogs
37 SSTR
38 SSTR ligands
39 alternative approach
40 amount
41 analogues
42 approach
43 blood cells
44 carcinoid tumors
45 cell lines
46 cells
47 differences
48 high amounts
49 intestinal carcinoid tumors
50 iodine
51 labeling
52 ligands
53 lines
54 localization
55 localization of tumors
56 low-affinity one
57 medicine department
58 minority
59 minority of patients
60 normal peripheral blood cells
61 nuclear medicine department
62 number
63 octreotide
64 one
65 patients
66 peripheral blood cells
67 primary tumor
68 properties
69 radiolabelled SST analogues
70 receptors
71 results
72 scanning properties
73 scintigraphic results
74 somatostatin
75 somatostatin analogues
76 study
77 subpopulations
78 tumor cell lines
79 tumor cells
80 tumors
81 variety
82 vitro
83 vivo
84 vivo studies
85 schema:name In vitro and in vivo studies of three radiolabelled somatostatin analogues:123I-Octreotide (OCT),123I-Tyr-3-OCT and111In-TIRA-d-Phe-1-OCT
86 schema:pagination 1388-1399
87 schema:productId N3142b45747474bb39e59cf9ca94f492c
88 N3a70e55bdea34ceaab9061ed932738b1
89 Nd114111c03c5488781d0f34b12c64f93
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044712964
91 https://doi.org/10.1007/bf01367597
92 schema:sdDatePublished 2022-05-10T09:50
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Nea40db243002431cb5a89a383216234d
95 schema:url https://doi.org/10.1007/bf01367597
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N020ed2ee7cb64acca7dec1528d558022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Indium Radioisotopes
101 rdf:type schema:DefinedTerm
102 N037a9220d1514199ad303777e7558b9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Adolescent
104 rdf:type schema:DefinedTerm
105 N0b85817fc3fa410a8a65884808ba2e13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Tumor Cells, Cultured
107 rdf:type schema:DefinedTerm
108 N208de3c538ba4c4e9bf255b9ac41a1ba schema:issueNumber 10
109 rdf:type schema:PublicationIssue
110 N2d9e54d8d86847268156aa1e0a69eda7 rdf:first sg:person.01046032607.37
111 rdf:rest N3c495af457fe4aa987427cdea6610b7c
112 N2db5addcdf0a4bbd8e2c0be4a4e3c7e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Receptors, Somatostatin
114 rdf:type schema:DefinedTerm
115 N3142b45747474bb39e59cf9ca94f492c schema:name doi
116 schema:value 10.1007/bf01367597
117 rdf:type schema:PropertyValue
118 N3729fae034b6419fa712aeaa462c211e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Iodine Radioisotopes
120 rdf:type schema:DefinedTerm
121 N3a70e55bdea34ceaab9061ed932738b1 schema:name pubmed_id
122 schema:value 8781146
123 rdf:type schema:PropertyValue
124 N3c495af457fe4aa987427cdea6610b7c rdf:first sg:person.0713515512.66
125 rdf:rest N784f12787ef0414d888e904d86210bfc
126 N3ebfb8bcb70b4e6e95a6914788f68dc6 schema:volumeNumber 23
127 rdf:type schema:PublicationVolume
128 N43515d0d851046f5a1fc833b4552bfcc rdf:first sg:person.067542523.39
129 rdf:rest Nfada976bc031413cb4d6aff05a97a13a
130 N6138b68a59cf49209d7f901b6b38960a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name In Vitro Techniques
132 rdf:type schema:DefinedTerm
133 N6577c17ce1244b66ad2b87de94a38460 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Middle Aged
135 rdf:type schema:DefinedTerm
136 N6ba97c2daf61499b8b59b3d5901b19b4 rdf:first sg:person.01355220604.52
137 rdf:rest Nfa9dc4266f2f4180a6afe65a8943c931
138 N6c986714308640369ba10eab3ee8137f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Male
140 rdf:type schema:DefinedTerm
141 N74bed09d23384732ab2a57251c3668b5 rdf:first sg:person.01311044454.32
142 rdf:rest N78793620aeed4df690981648dde3bcf5
143 N76dc7eb6746a4be0a74da88db25bbb48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 N784f12787ef0414d888e904d86210bfc rdf:first sg:person.0671724636.94
147 rdf:rest N98eb3f62b89a41c28fd7fe5a101a82c6
148 N78793620aeed4df690981648dde3bcf5 rdf:first sg:person.01046040764.07
149 rdf:rest Na4e7e0737ef84b758eaea7f33052d9bf
150 N7fab78b6c4674010af45458dc2bb0bab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Octreotide
152 rdf:type schema:DefinedTerm
153 N838dfe42cce140b98456f77f8dbfc747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Female
155 rdf:type schema:DefinedTerm
156 N9079fc26a8cd4bceb2d1a08332e0f48c rdf:first sg:person.0764224033.26
157 rdf:rest N43515d0d851046f5a1fc833b4552bfcc
158 N96cd6370212f40c0955bad3fed27a4b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Aged
160 rdf:type schema:DefinedTerm
161 N98eb3f62b89a41c28fd7fe5a101a82c6 rdf:first sg:person.014224752232.33
162 rdf:rest Naa106fdf532244bba7665376ffa92278
163 Na0dc18b745084619ae26ce23264d7dca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Neoplasms
165 rdf:type schema:DefinedTerm
166 Na4e7e0737ef84b758eaea7f33052d9bf rdf:first sg:person.0644623102.88
167 rdf:rest N2d9e54d8d86847268156aa1e0a69eda7
168 Na62759796496493093179f9567ad11dc rdf:first sg:person.01263066417.01
169 rdf:rest N6ba97c2daf61499b8b59b3d5901b19b4
170 Naa106fdf532244bba7665376ffa92278 rdf:first sg:person.0746740737.70
171 rdf:rest rdf:nil
172 Nbffa88753b264b9582fb48f7d18d6e34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Adult
174 rdf:type schema:DefinedTerm
175 Nc0610a8f1dfe4da4826fbb5a3cc88a91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Radionuclide Imaging
177 rdf:type schema:DefinedTerm
178 Nd114111c03c5488781d0f34b12c64f93 schema:name dimensions_id
179 schema:value pub.1044712964
180 rdf:type schema:PropertyValue
181 Nea40db243002431cb5a89a383216234d schema:name Springer Nature - SN SciGraph project
182 rdf:type schema:Organization
183 Nf5fbe1ef8e3c4abf9d0f606011d697f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Carcinoid Tumor
185 rdf:type schema:DefinedTerm
186 Nf7478651ace842d0b5635762a1a07ae9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Pentetic Acid
188 rdf:type schema:DefinedTerm
189 Nfa9dc4266f2f4180a6afe65a8943c931 rdf:first sg:person.01234601050.40
190 rdf:rest N74bed09d23384732ab2a57251c3668b5
191 Nfada976bc031413cb4d6aff05a97a13a rdf:first sg:person.0771074626.92
192 rdf:rest Na62759796496493093179f9567ad11dc
193 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
194 schema:name Medical and Health Sciences
195 rdf:type schema:DefinedTerm
196 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
197 schema:name Oncology and Carcinogenesis
198 rdf:type schema:DefinedTerm
199 sg:journal.1297401 schema:issn 1619-7070
200 1619-7089
201 schema:name European Journal of Nuclear Medicine and Molecular Imaging
202 schema:publisher Springer Nature
203 rdf:type schema:Periodical
204 sg:person.01046032607.37 schema:affiliation grid-institutes:grid.10420.37
205 schema:familyName Peck-Radosavljevic
206 schema:givenName Markus
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046032607.37
208 rdf:type schema:Person
209 sg:person.01046040764.07 schema:affiliation grid-institutes:grid.10420.37
210 schema:familyName Kaserer
211 schema:givenName Klaus
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046040764.07
213 rdf:type schema:Person
214 sg:person.01234601050.40 schema:affiliation grid-institutes:grid.10420.37
215 schema:familyName Raderer
216 schema:givenName Markus
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234601050.40
218 rdf:type schema:Person
219 sg:person.01263066417.01 schema:affiliation grid-institutes:grid.10420.37
220 schema:familyName Yang
221 schema:givenName Qiong
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263066417.01
223 rdf:type schema:Person
224 sg:person.01311044454.32 schema:affiliation grid-institutes:grid.10420.37
225 schema:familyName Neuhold
226 schema:givenName Nikolaus
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311044454.32
228 rdf:type schema:Person
229 sg:person.01355220604.52 schema:affiliation grid-institutes:grid.10420.37
230 schema:familyName Kurtaran
231 schema:givenName Amir
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355220604.52
233 rdf:type schema:Person
234 sg:person.014224752232.33 schema:affiliation grid-institutes:grid.10420.37
235 schema:familyName Eichler
236 schema:givenName Hans-Georg
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014224752232.33
238 rdf:type schema:Person
239 sg:person.0644623102.88 schema:affiliation grid-institutes:grid.10420.37
240 schema:familyName Leimer
241 schema:givenName Maria
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644623102.88
243 rdf:type schema:Person
244 sg:person.0671724636.94 schema:affiliation grid-institutes:grid.10420.37
245 schema:familyName Niederle
246 schema:givenName Bruno
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671724636.94
248 rdf:type schema:Person
249 sg:person.067542523.39 schema:affiliation grid-institutes:None
250 schema:familyName Angelberger
251 schema:givenName Peter
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.067542523.39
253 rdf:type schema:Person
254 sg:person.0713515512.66 schema:affiliation grid-institutes:None
255 schema:familyName Scheithauer
256 schema:givenName Werner
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713515512.66
258 rdf:type schema:Person
259 sg:person.0746740737.70 schema:affiliation grid-institutes:grid.10420.37
260 schema:familyName Valent
261 schema:givenName Peter
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746740737.70
263 rdf:type schema:Person
264 sg:person.0764224033.26 schema:affiliation grid-institutes:grid.10420.37
265 schema:familyName Virgolini
266 schema:givenName Irene
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764224033.26
268 rdf:type schema:Person
269 sg:person.0771074626.92 schema:affiliation grid-institutes:grid.10420.37
270 schema:familyName Li
271 schema:givenName Shuren
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771074626.92
273 rdf:type schema:Person
274 sg:pub.10.1007/978-94-011-3034-9_262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1089760933
275 https://doi.org/10.1007/978-94-011-3034-9_262
276 rdf:type schema:CreativeWork
277 sg:pub.10.1007/bf00181765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016946247
278 https://doi.org/10.1007/bf00181765
279 rdf:type schema:CreativeWork
280 grid-institutes:None schema:alternateName Department of Radiochemistry, Research Center Seibersdorf, Austria
281 schema:name Department of Radiochemistry, Research Center Seibersdorf, Austria
282 rdf:type schema:Organization
283 grid-institutes:grid.10420.37 schema:alternateName Department of Clinical Pharmacology, University of Vienna, Austria
284 Department of Gastroenterology, University of Vienna, Austria
285 Department of Hematology, University of Vienna, Austria
286 Department of Nuclear Medicine, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria
287 Department of Oncology, University of Vienna, Austria
288 Department of Pathology, University of Vienna, Austria
289 Department of Surgery, University of Vienna, Austria
290 The Ludwig Boltzmann Institute of Nuclear Medicine, University of Vienna, Austria
291 schema:name Department of Clinical Pharmacology, University of Vienna, Austria
292 Department of Gastroenterology, University of Vienna, Austria
293 Department of Hematology, University of Vienna, Austria
294 Department of Nuclear Medicine, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria
295 Department of Oncology, University of Vienna, Austria
296 Department of Pathology, University of Vienna, Austria
297 Department of Surgery, University of Vienna, Austria
298 The Ludwig Boltzmann Institute of Nuclear Medicine, University of Vienna, Austria
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...