A method for the study of the metabolism of isolated mammalian islets of Langerhans and some preliminary results View Full Text


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Article Info

DATE

1965-08

AUTHORS

Harry Keen, Robert Sells, R. John Jarrett

ABSTRACT

Isolated islets of Langerhans, micro-dissected from the duct-ligated pancreas in the rat, survived for at least four hours of incubation, their rate of glucose oxidation continuing linearly during this period. Oxidation of 1-14C-glucose was considerably higher when the glucose concentration in the medium was raised and comparison with other tissue suggested that glucose oxidation of the islets, in particular that by the hexose monophosphate pathway, was specifically stimulated by the higher glucose concentrations. This may well be directly associated with the glucose stimulus to insulin release. Activity of the hexose monophosphate pathway has previously been demonstrated in both fish and mammalian islets and in human islet cell tumours, both by enzyme estimations and by studies with labelled glucose, and the suggestion has been made that activity of the pathway may be linked with insulin synthesis (Field, 1964). More... »

PAGES

28-32

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01338712

DOI

http://dx.doi.org/10.1007/bf01338712

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041645315


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