Ontology type: schema:ScholarlyArticle Open Access: True
1965-08
AUTHORSHarry Keen, Robert Sells, R. John Jarrett
ABSTRACTIsolated islets of Langerhans, micro-dissected from the duct-ligated pancreas in the rat, survived for at least four hours of incubation, their rate of glucose oxidation continuing linearly during this period. Oxidation of 1-14C-glucose was considerably higher when the glucose concentration in the medium was raised and comparison with other tissue suggested that glucose oxidation of the islets, in particular that by the hexose monophosphate pathway, was specifically stimulated by the higher glucose concentrations. This may well be directly associated with the glucose stimulus to insulin release. Activity of the hexose monophosphate pathway has previously been demonstrated in both fish and mammalian islets and in human islet cell tumours, both by enzyme estimations and by studies with labelled glucose, and the suggestion has been made that activity of the pathway may be linked with insulin synthesis (Field, 1964). More... »
PAGES28-32
http://scigraph.springernature.com/pub.10.1007/bf01338712
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