Residual radiation effect in the murine spleen. In situ measurement by 125-iodo-deoxyuridine retention View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-09

AUTHORS

G. E. Hübner, K. -H. v. Wangenheim, L. E. Feinendegen

ABSTRACT

To investigate whether residual radiation damage in hematopoietic tissue is measurable in situ by a change in cell turnover, the retention of the thymidine analogue 5-(125-I)iodo-2'-deoxyuridine (125-IUdR) following incorporation into DNA of cells in bone marrow and spleen of mice was measured 35 days after 0-500 rad whole body gamma irradiation. In the bone marrow a rapid and a slow turnover component of 125-IUdR retention were found. Both components were almost identical for unirradiated and irradiated mice. In the spleen the 125-IUdR retention curves exhibited three components with increasingly prolonged half-times. In the second component the half-time was longer in irradiated than in unirradiated mice. This was dose-dependent. The increased half-time of 125-IUdR retention in irradiated spleens may be caused by direct cellular damage of long-lived cells (lymphocytes, early hematopoietic progenitor cells) or/and by diminished stimulation of proliferation by microenvironmental or long-range factors. More... »

PAGES

195-200

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01325468

DOI

http://dx.doi.org/10.1007/bf01325468

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043019279

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7051130


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