Fixation, retention and exhalation of carrier-free11C-Labeled carbon monoxide by man View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-12

AUTHORS

R. Weinreich, F. Ritzl, L. E. Feinendegen, H. G. Schnippering, G. Stöcklin

ABSTRACT

Carrier-free 11C-labeled carbon monoxide was produced by proton irradiation of a nitrogen gas flow target via the 14N(p, alpha)11C process followed by on-line reduction of the predominantly formed 11C-carbon dioxide with a yield of 0.4 mCi/muAmin. After appropriate quality control about 2 mCi of carrier-free 11C-carbon monoxide in 500 ml on nitrogen gas were inhaled by test subjects in one breath. The 11C-activity distribution was then followed in vivo by scanning above thorax, head, liver, thigh and os sacrum; simultaneously the 11c-activity of the blood was also followed by batch measurement. The data indicate that part of the 11C-activity migrates from the blood into the intercellular space, while another part is exhaled. The 11C-activity leaves the individual organs with a biological half-life ranging from about 120 to 200 min, a time which is short as compared to the one observed for 51Cr-labeled erythrocytes. A radio gas chromatographic analysis of the exhaled air showed that the 11C-activity leaves the body exculsively in the form of 11C-labeled carbon monoxide. Consequently, metabolism of the 11CO into 11CO2 or other compounds can be excluded. More... »

PAGES

271-280

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01323415

DOI

http://dx.doi.org/10.1007/bf01323415

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018884560

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1202560


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