Individual translational efficiencies of SV 40 and cellular mRNAs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-03

AUTHORS

H. Oppermann, G. Koch

ABSTRACT

The technique of selective inhibition of peptide chain initiation by growth medium hypertonicity was adapted for cell monolayer cultures and applied to a study of protein synthesis in SV 40 infected BSC-1 cells. The translational efficiences for individual peptide chain initiation sites on SV 40 mRNAs were determined and compared to those for cellular mRNA species under conditions of a reduced rate of peptide chain initiation. The SV 40 mRNAs show different translational efficiencies. The results indicate that the synthesis of the SV 40 proteins VP1, 2 and 3 are initiated independently and with different rates on viral mRNA(s). It is proposed, therefore, that VP2 is not a precursor for VP3. More... »

PAGES

123-134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01317871

DOI

http://dx.doi.org/10.1007/bf01317871

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003175784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/187145


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