Ontology type: schema:ScholarlyArticle
1990-03
AUTHORSJ. S. Oxford, G. C. Schild, T. Corcoran, R. Newman, D. Major, J. Robertson, J. Bootman, P. Higgins, W. Al-Nakib, D. A. J. Tyrrell
ABSTRACTAn influenza B virus was passaged in man (virus A) and then in human embryo trachea (C) and into embryonated eggs (D) or directly into eggs (B). Virus A, B, and C had the same (cell-like) haemagglutinin phenotype on reaction with selected monoclonal antibodies while D had an “egg-like” phenotype. The viruses were administered at a dose of 1,000 TCD50 (for MDCK cells) by intranasal inoculation to groups of 27 or 28 volunteers. Viruses A, B, and C all produced disease in six to eight volunteers, whereas D produced no illness and only four volunteers were infected. The viruses shed by the volunteers were indistinguishable from those with which they were inoculated. The haemagglutinin genes of the viruses were sequenced and changes were detected indicating amino acid substitutions at position 196–198 in the attenuated egg-grown virus D whereby a potential glycosylation site present in the other viruses was lost. More... »
PAGES37-46
http://scigraph.springernature.com/pub.10.1007/bf01310701
DOIhttp://dx.doi.org/10.1007/bf01310701
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1003883828
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/2310304
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Microbiology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amino Acid Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Base Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Variation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glycosylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hemagglutination Inhibition Tests",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hemagglutinins, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Influenza B virus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Sequence Data",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Selection, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Serial Passage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Virulence",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "The London Hospital Medical College, London",
"id": "http://www.grid.ac/institutes/grid.4868.2",
"name": [
"The London Hospital Medical College, London"
],
"type": "Organization"
},
"familyName": "Oxford",
"givenName": "J. S.",
"id": "sg:person.01211647624.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211647624.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/grid.70909.37",
"name": [
"National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Schild",
"givenName": "G. C.",
"id": "sg:person.01253673243.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253673243.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/grid.70909.37",
"name": [
"National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Corcoran",
"givenName": "T.",
"id": "sg:person.01207305442.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207305442.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/grid.70909.37",
"name": [
"National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Newman",
"givenName": "R.",
"id": "sg:person.01353512640.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353512640.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/grid.70909.37",
"name": [
"National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Major",
"givenName": "D.",
"id": "sg:person.0634267022.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634267022.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/grid.70909.37",
"name": [
"National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Robertson",
"givenName": "J.",
"id": "sg:person.0724417104.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724417104.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/grid.70909.37",
"name": [
"National Institute for Biological Standards and Control, Potters Bar Hertfordshire, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Bootman",
"givenName": "J.",
"id": "sg:person.01173253776.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173253776.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/None",
"name": [
"MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Higgins",
"givenName": "P.",
"id": "sg:person.01262613014.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262613014.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/None",
"name": [
"MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Al-Nakib",
"givenName": "W.",
"id": "sg:person.01152342177.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152342177.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, England",
"id": "http://www.grid.ac/institutes/None",
"name": [
"MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, England"
],
"type": "Organization"
},
"familyName": "Tyrrell",
"givenName": "D. A. J.",
"id": "sg:person.015070115202.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015070115202.87"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/303706a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017573638",
"https://doi.org/10.1038/303706a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01310874",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044002071",
"https://doi.org/10.1007/bf01310874"
],
"type": "CreativeWork"
}
],
"datePublished": "1990-03",
"datePublishedReg": "1990-03-01",
"description": "An influenza B virus was passaged in man (virus A) and then in human embryo trachea (C) and into embryonated eggs (D) or directly into eggs (B). Virus A, B, and C had the same (cell-like) haemagglutinin phenotype on reaction with selected monoclonal antibodies while D had an \u201cegg-like\u201d phenotype. The viruses were administered at a dose of 1,000 TCD50 (for MDCK cells) by intranasal inoculation to groups of 27 or 28 volunteers. Viruses A, B, and C all produced disease in six to eight volunteers, whereas D produced no illness and only four volunteers were infected. The viruses shed by the volunteers were indistinguishable from those with which they were inoculated. The haemagglutinin genes of the viruses were sequenced and changes were detected indicating amino acid substitutions at position 196\u2013198 in the attenuated egg-grown virus D whereby a potential glycosylation site present in the other viruses was lost.",
"genre": "article",
"id": "sg:pub.10.1007/bf01310701",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1083335",
"issn": [
"0304-8608",
"1432-8798"
],
"name": "Archives of Virology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1-2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "110"
}
],
"keywords": [
"influenza B virus",
"B virus",
"virus A",
"intranasal inoculation",
"monoclonal antibodies",
"volunteers",
"virus",
"haemagglutinin gene",
"amino acid substitutions",
"single nucleotide substitution",
"phenotype",
"acid substitutions",
"TCD50",
"position 196",
"potential glycosylation sites",
"illness",
"trachea",
"disease",
"dose",
"antibodies",
"men",
"glycosylation sites",
"eggs",
"nucleotide substitutions",
"group",
"virulence",
"inoculation",
"sites",
"variants",
"genes",
"changes",
"HA",
"substitution",
"reaction"
],
"name": "A host-cell-selected variant of influenza B virus with a single nucleotide substitution in HA affecting a potential glycosylation site was attentuated in virulence for volunteers",
"pagination": "37-46",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1003883828"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf01310701"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"2310304"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf01310701",
"https://app.dimensions.ai/details/publication/pub.1003883828"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_257.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/bf01310701"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01310701'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01310701'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01310701'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01310701'
This table displays all metadata directly associated to this object as RDF triples.
225 TRIPLES
22 PREDICATES
76 URIs
66 LITERALS
20 BLANK NODES