Protection by dehydroepiandrosterone in mice infected with viral encephalitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-09

AUTHORS

D. Ben-Nathan, B. Lachmi, S. Lustig, G. Feuerstein

ABSTRACT

Dehydroepiandrosterone (DHEA) has a significant protective effect in mice infected with West Nile virus (WNV), Sindbis virus neurovirulent (SVNI) and Semliki Forest virus (SFV). Mice injected subcutaneously (SC) with a single injection of DHEA (1 g/kg) on the same day or one day pre or post infection with WNV resulted in 40-50% mortality as compared to 100% in control injected mice (p less than 0.05). The drug was effective following a single SC injection or serial intraperitoneal (IP) injections (5-20 mg/kg) on days 0, 2, 4, and 6 following virus inoculation. Moreover, DHEA injection not only reduced viremia and death rate, but also significantly delayed the onset of the disease and mortality. The titers of antivirus antibodies in surviving mice were very high. However, DHEA had no effect on WNV growth in BHK or Vero cell cultures. In this study it was shown that DHEA protects mice against WNV, SVNI and SFV lethal infection. Though the mechanism of the protective effect of DHEA is still unknown, it seems that DHEA can modify the host resistance mechanisms rather than the virus itself. More... »

PAGES

263-271

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01310481

DOI

http://dx.doi.org/10.1007/bf01310481

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010085108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1659799


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