Correlation between detection of anti-viral antibody and histopathological disease activity in an epidemic of hepatitis C View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-03

AUTHORS

Y. Fukuda, H. Nagura, T. Takayama, M. Imoto, M. Shibata, T. Kudo, T. Morishima, T. Miyamura, Y. Nagai

ABSTRACT

There was an epidemic of non-A non-B hepatitis in a small area of a town in the central part of Japan, which began with an outbreak of several patients in 1981 and then spread extensively with the result that about one third of the inhabitants showed abnormality in serum liver function tests at the health check performed in 1985. We determined histological diagnoses on that occasion for 167 individuals of the abnormal population and recently assayed antibodies against hepatitis C virus (HCV) for most of their sera left available. Histologically, chronic active hepatitis (CAH) was the major pattern, accounting for 59.3% (99 cases) of the total. Others were chronic persistent hepatitis (CPH) (13.2%), chronic lobular hepatitis (CLH) (16.2%), liver cirrhosis (LC) (6.6%) and fatty liver (4.8%). In the serological studies, the newly developed system to detect antibodies against the viral core protein p 22 was found to be much more sensitive than the conventional system to detect anti C 100-3 antibodies. By using these two methods in combination, we found that 82% were antibody-positive, indicating strong implication of HCV in this epidemic. This was further supported by direct detection of the viral genome in patients' sera by polymerase chain reaction following reverse transcription. We further found a strong correlation between the histological inflammatory activity and the antibody prevalence, since nearly all (97.6%) of the CAH cases were antibody-positive by at least either of the antibody assays, while only about 50% were positive in the less active cases such as CPH and CLH. More... »

PAGES

171-178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01309693

DOI

http://dx.doi.org/10.1007/bf01309693

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023173748

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1381909


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Outbreaks", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepacivirus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis C Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuda", 
        "givenName": "Y.", 
        "id": "sg:person.01070564772.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070564772.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagura", 
        "givenName": "H.", 
        "id": "sg:person.0723362470.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sakashita Hosptial, Sakashita", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sakashita Hosptial, Sakashita"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takayama", 
        "givenName": "T.", 
        "id": "sg:person.015125304032.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015125304032.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imoto", 
        "givenName": "M.", 
        "id": "sg:person.01253352541.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253352541.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Nagoya University School of Medicine, Nagoya", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Pediatrics, Nagoya University School of Medicine, Nagoya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shibata", 
        "givenName": "M.", 
        "id": "sg:person.01204403560.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204403560.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Nagoya University School of Medicine, Nagoya", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Pediatrics, Nagoya University School of Medicine, Nagoya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kudo", 
        "givenName": "T.", 
        "id": "sg:person.01261747164.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261747164.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Nagoya University School of Medicine, Nagoya", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Pediatrics, Nagoya University School of Medicine, Nagoya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morishima", 
        "givenName": "T.", 
        "id": "sg:person.014016402054.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014016402054.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Health, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410797.c", 
          "name": [
            "National Institute of Health, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyamura", 
        "givenName": "T.", 
        "id": "sg:person.0602056476.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602056476.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagai", 
        "givenName": "Y.", 
        "id": "sg:person.010335250642.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010335250642.15"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1992-03", 
    "datePublishedReg": "1992-03-01", 
    "description": "There was an epidemic of non-A non-B hepatitis in a small area of a town in the central part of Japan, which began with an outbreak of several patients in 1981 and then spread extensively with the result that about one third of the inhabitants showed abnormality in serum liver function tests at the health check performed in 1985. We determined histological diagnoses on that occasion for 167 individuals of the abnormal population and recently assayed antibodies against hepatitis C virus (HCV) for most of their sera left available. Histologically, chronic active hepatitis (CAH) was the major pattern, accounting for 59.3% (99 cases) of the total. Others were chronic persistent hepatitis (CPH) (13.2%), chronic lobular hepatitis (CLH) (16.2%), liver cirrhosis (LC) (6.6%) and fatty liver (4.8%). In the serological studies, the newly developed system to detect antibodies against the viral core protein p 22 was found to be much more sensitive than the conventional system to detect anti C 100-3 antibodies. By using these two methods in combination, we found that 82% were antibody-positive, indicating strong implication of HCV in this epidemic. This was further supported by direct detection of the viral genome in patients' sera by polymerase chain reaction following reverse transcription. We further found a strong correlation between the histological inflammatory activity and the antibody prevalence, since nearly all (97.6%) of the CAH cases were antibody-positive by at least either of the antibody assays, while only about 50% were positive in the less active cases such as CPH and CLH.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01309693", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1083335", 
        "issn": [
          "0304-8608", 
          "1432-8798"
        ], 
        "name": "Archives of Virology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "126"
      }
    ], 
    "keywords": [
      "chronic lobular hepatitis", 
      "chronic persistent hepatitis", 
      "hepatitis C virus", 
      "chronic active hepatitis", 
      "liver cirrhosis", 
      "serum liver function tests", 
      "anti-viral antibodies", 
      "histological inflammatory activity", 
      "liver function tests", 
      "lobular hepatitis", 
      "persistent hepatitis", 
      "active hepatitis", 
      "disease activity", 
      "hepatitis C", 
      "function tests", 
      "inflammatory activity", 
      "histological diagnosis", 
      "fatty liver", 
      "antibody prevalence", 
      "polymerase chain reaction", 
      "patient sera", 
      "health check", 
      "hepatitis", 
      "active cases", 
      "serological studies", 
      "CAH cases", 
      "abnormal population", 
      "antibodies", 
      "chain reaction", 
      "serum", 
      "epidemic", 
      "reverse transcription", 
      "viral genome", 
      "cirrhosis", 
      "patients", 
      "prevalence", 
      "abnormalities", 
      "diagnosis", 
      "strong correlation", 
      "liver", 
      "virus", 
      "total", 
      "major patterns", 
      "activity", 
      "cases", 
      "correlation", 
      "outbreak", 
      "third", 
      "population", 
      "individuals", 
      "occasions", 
      "study", 
      "detection", 
      "test", 
      "combination", 
      "transcription", 
      "patterns", 
      "inhabitants", 
      "small area", 
      "area", 
      "Japan", 
      "results", 
      "implications", 
      "direct detection", 
      "part", 
      "strong implications", 
      "reaction", 
      "system", 
      "method", 
      "town", 
      "central part", 
      "check", 
      "genome", 
      "conventional system", 
      "C virus", 
      "viral core protein p 22", 
      "core protein p 22", 
      "protein p 22", 
      "p 22", 
      "histopathological disease activity"
    ], 
    "name": "Correlation between detection of anti-viral antibody and histopathological disease activity in an epidemic of hepatitis C", 
    "pagination": "171-178", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023173748"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01309693"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1381909"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01309693", 
      "https://app.dimensions.ai/details/publication/pub.1023173748"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_223.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01309693"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01309693'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01309693'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01309693'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01309693'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      21 PREDICATES      121 URIs      113 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01309693 schema:about N06e7a36bac794116b749b8b43150befe
2 N263580936c014dd68ae2df246bff1050
3 N48332fe39e2f4dec898a825f705fd8c6
4 N5632ae4824b048f8b49e25b47e03e157
5 N9c1ea35f8d494edd935d59753a3530a1
6 Na1cd01aaafef4c9b84e63f60926b898e
7 Nadea1d4c074b47268cea1f286b4603a2
8 Nb248a0af8ab7488cac16b13ba586dae7
9 Nca9e384c36c34df082bc81b8966918be
10 Nce9cf92fbafe472a8dfe6a84a1c445ea
11 Ndb7ad15b93dd4989932fa3d1625745cb
12 Ne520f848a44c429ba6b732fd57155bf3
13 Ne57e3f81ce0e42eca2d26ff491535b3e
14 Ne91c57f96a704f7ab5d0753f19d47fa0
15 anzsrc-for:11
16 anzsrc-for:1108
17 schema:author N245f576f78584a6d928116054f2f70bf
18 schema:datePublished 1992-03
19 schema:datePublishedReg 1992-03-01
20 schema:description There was an epidemic of non-A non-B hepatitis in a small area of a town in the central part of Japan, which began with an outbreak of several patients in 1981 and then spread extensively with the result that about one third of the inhabitants showed abnormality in serum liver function tests at the health check performed in 1985. We determined histological diagnoses on that occasion for 167 individuals of the abnormal population and recently assayed antibodies against hepatitis C virus (HCV) for most of their sera left available. Histologically, chronic active hepatitis (CAH) was the major pattern, accounting for 59.3% (99 cases) of the total. Others were chronic persistent hepatitis (CPH) (13.2%), chronic lobular hepatitis (CLH) (16.2%), liver cirrhosis (LC) (6.6%) and fatty liver (4.8%). In the serological studies, the newly developed system to detect antibodies against the viral core protein p 22 was found to be much more sensitive than the conventional system to detect anti C 100-3 antibodies. By using these two methods in combination, we found that 82% were antibody-positive, indicating strong implication of HCV in this epidemic. This was further supported by direct detection of the viral genome in patients' sera by polymerase chain reaction following reverse transcription. We further found a strong correlation between the histological inflammatory activity and the antibody prevalence, since nearly all (97.6%) of the CAH cases were antibody-positive by at least either of the antibody assays, while only about 50% were positive in the less active cases such as CPH and CLH.
21 schema:genre article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf N310f4eaa277b4fc78a30e7036a09bb8c
25 N8b33b3b642bd4dbb8145361a821a139a
26 sg:journal.1083335
27 schema:keywords C virus
28 CAH cases
29 Japan
30 abnormal population
31 abnormalities
32 active cases
33 active hepatitis
34 activity
35 anti-viral antibodies
36 antibodies
37 antibody prevalence
38 area
39 cases
40 central part
41 chain reaction
42 check
43 chronic active hepatitis
44 chronic lobular hepatitis
45 chronic persistent hepatitis
46 cirrhosis
47 combination
48 conventional system
49 core protein p 22
50 correlation
51 detection
52 diagnosis
53 direct detection
54 disease activity
55 epidemic
56 fatty liver
57 function tests
58 genome
59 health check
60 hepatitis
61 hepatitis C
62 hepatitis C virus
63 histological diagnosis
64 histological inflammatory activity
65 histopathological disease activity
66 implications
67 individuals
68 inflammatory activity
69 inhabitants
70 liver
71 liver cirrhosis
72 liver function tests
73 lobular hepatitis
74 major patterns
75 method
76 occasions
77 outbreak
78 p 22
79 part
80 patient sera
81 patients
82 patterns
83 persistent hepatitis
84 polymerase chain reaction
85 population
86 prevalence
87 protein p 22
88 reaction
89 results
90 reverse transcription
91 serological studies
92 serum
93 serum liver function tests
94 small area
95 strong correlation
96 strong implications
97 study
98 system
99 test
100 third
101 total
102 town
103 transcription
104 viral core protein p 22
105 viral genome
106 virus
107 schema:name Correlation between detection of anti-viral antibody and histopathological disease activity in an epidemic of hepatitis C
108 schema:pagination 171-178
109 schema:productId N7dd77ad167a3461c8d9139736330017f
110 Na6a0a8bc954d4618b851cfbca30f8f49
111 Nca80e117fa0b4adbba1aeee81fdd1820
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023173748
113 https://doi.org/10.1007/bf01309693
114 schema:sdDatePublished 2022-01-01T18:05
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher N32c5832a518e4125b0b4435a3ac06603
117 schema:url https://doi.org/10.1007/bf01309693
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N06e7a36bac794116b749b8b43150befe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Disease Outbreaks
123 rdf:type schema:DefinedTerm
124 N1c7fa857a625454b92375cd95ad2677e rdf:first sg:person.01261747164.27
125 rdf:rest N676deb550a4b4de09c63423ec914fa07
126 N1d60ce7dbaa14187b81f5c1701b553e0 rdf:first sg:person.015125304032.70
127 rdf:rest N659d79b85eec46dfac2684b99f26c4ff
128 N245f576f78584a6d928116054f2f70bf rdf:first sg:person.01070564772.15
129 rdf:rest Ne06d1f8f6e5e45d3bab407168db3e65b
130 N263580936c014dd68ae2df246bff1050 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N310f4eaa277b4fc78a30e7036a09bb8c schema:issueNumber 1-4
134 rdf:type schema:PublicationIssue
135 N32c5832a518e4125b0b4435a3ac06603 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N48332fe39e2f4dec898a825f705fd8c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Prevalence
139 rdf:type schema:DefinedTerm
140 N5632ae4824b048f8b49e25b47e03e157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Japan
142 rdf:type schema:DefinedTerm
143 N57346032f78f4ab8a835d41d67bd4e8d rdf:first sg:person.01204403560.44
144 rdf:rest N1c7fa857a625454b92375cd95ad2677e
145 N659d79b85eec46dfac2684b99f26c4ff rdf:first sg:person.01253352541.81
146 rdf:rest N57346032f78f4ab8a835d41d67bd4e8d
147 N676deb550a4b4de09c63423ec914fa07 rdf:first sg:person.014016402054.80
148 rdf:rest Nfe1e046208ec4ee1b24d4f0c2c580c95
149 N7dd77ad167a3461c8d9139736330017f schema:name doi
150 schema:value 10.1007/bf01309693
151 rdf:type schema:PropertyValue
152 N8b33b3b642bd4dbb8145361a821a139a schema:volumeNumber 126
153 rdf:type schema:PublicationVolume
154 N9c1ea35f8d494edd935d59753a3530a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Molecular Sequence Data
156 rdf:type schema:DefinedTerm
157 Na1cd01aaafef4c9b84e63f60926b898e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Retrospective Studies
159 rdf:type schema:DefinedTerm
160 Na6a0a8bc954d4618b851cfbca30f8f49 schema:name pubmed_id
161 schema:value 1381909
162 rdf:type schema:PropertyValue
163 Nadea1d4c074b47268cea1f286b4603a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Hepatitis C Antibodies
165 rdf:type schema:DefinedTerm
166 Nb248a0af8ab7488cac16b13ba586dae7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Hepatitis C
168 rdf:type schema:DefinedTerm
169 Nc2b74a534f9a4ad4a15fe955f06634dd rdf:first sg:person.010335250642.15
170 rdf:rest rdf:nil
171 Nca80e117fa0b4adbba1aeee81fdd1820 schema:name dimensions_id
172 schema:value pub.1023173748
173 rdf:type schema:PropertyValue
174 Nca9e384c36c34df082bc81b8966918be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Hepacivirus
176 rdf:type schema:DefinedTerm
177 Nce9cf92fbafe472a8dfe6a84a1c445ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Polymerase Chain Reaction
179 rdf:type schema:DefinedTerm
180 Ndb7ad15b93dd4989932fa3d1625745cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Base Sequence
182 rdf:type schema:DefinedTerm
183 Ne06d1f8f6e5e45d3bab407168db3e65b rdf:first sg:person.0723362470.15
184 rdf:rest N1d60ce7dbaa14187b81f5c1701b553e0
185 Ne520f848a44c429ba6b732fd57155bf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Middle Aged
187 rdf:type schema:DefinedTerm
188 Ne57e3f81ce0e42eca2d26ff491535b3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Genome, Viral
190 rdf:type schema:DefinedTerm
191 Ne91c57f96a704f7ab5d0753f19d47fa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Hepatitis Antibodies
193 rdf:type schema:DefinedTerm
194 Nfe1e046208ec4ee1b24d4f0c2c580c95 rdf:first sg:person.0602056476.28
195 rdf:rest Nc2b74a534f9a4ad4a15fe955f06634dd
196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medical and Health Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical Microbiology
201 rdf:type schema:DefinedTerm
202 sg:journal.1083335 schema:issn 0304-8608
203 1432-8798
204 schema:name Archives of Virology
205 schema:publisher Springer Nature
206 rdf:type schema:Periodical
207 sg:person.010335250642.15 schema:affiliation grid-institutes:grid.27476.30
208 schema:familyName Nagai
209 schema:givenName Y.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010335250642.15
211 rdf:type schema:Person
212 sg:person.01070564772.15 schema:affiliation grid-institutes:grid.27476.30
213 schema:familyName Fukuda
214 schema:givenName Y.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070564772.15
216 rdf:type schema:Person
217 sg:person.01204403560.44 schema:affiliation grid-institutes:grid.27476.30
218 schema:familyName Shibata
219 schema:givenName M.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204403560.44
221 rdf:type schema:Person
222 sg:person.01253352541.81 schema:affiliation grid-institutes:grid.27476.30
223 schema:familyName Imoto
224 schema:givenName M.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253352541.81
226 rdf:type schema:Person
227 sg:person.01261747164.27 schema:affiliation grid-institutes:grid.27476.30
228 schema:familyName Kudo
229 schema:givenName T.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261747164.27
231 rdf:type schema:Person
232 sg:person.014016402054.80 schema:affiliation grid-institutes:grid.27476.30
233 schema:familyName Morishima
234 schema:givenName T.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014016402054.80
236 rdf:type schema:Person
237 sg:person.015125304032.70 schema:affiliation grid-institutes:None
238 schema:familyName Takayama
239 schema:givenName T.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015125304032.70
241 rdf:type schema:Person
242 sg:person.0602056476.28 schema:affiliation grid-institutes:grid.410797.c
243 schema:familyName Miyamura
244 schema:givenName T.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602056476.28
246 rdf:type schema:Person
247 sg:person.0723362470.15 schema:affiliation grid-institutes:grid.27476.30
248 schema:familyName Nagura
249 schema:givenName H.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15
251 rdf:type schema:Person
252 grid-institutes:None schema:alternateName Sakashita Hosptial, Sakashita
253 schema:name Sakashita Hosptial, Sakashita
254 rdf:type schema:Organization
255 grid-institutes:grid.27476.30 schema:alternateName Department of Pediatrics, Nagoya University School of Medicine, Nagoya
256 Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya
257 Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
258 schema:name Department of Pediatrics, Nagoya University School of Medicine, Nagoya
259 Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya
260 Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya
261 rdf:type schema:Organization
262 grid-institutes:grid.410797.c schema:alternateName National Institute of Health, Tokyo, Japan
263 schema:name National Institute of Health, Tokyo, Japan
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...