Secretory component and lactoferrin in pure pancreatic juice in chronic pancreatitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-01

AUTHORS

Tetsuo Hayakawa, Takaharu Kondo, Tokimune Shibata, Toshiyuki Murase, Hideo Harada, Koji Ochi, Juntaro Tanaka

ABSTRACT

To evaluate pathophysiological roles of proteins in pancreatic secretion, immunoreactive lactoferrin (LF) and secretory component (SC) were measured in the first fraction of the pure pancreatic juice obtained endoscopically from 17 control, 21 suspected (SCP), 14 noncalcified (NCP), and 14 calcified chronic pancreatitis (CCP) subjects. The protein and amylase tended to decrease both in concentration and output from control to CCP. LF concentration was elevated in CCP (18.0±4.9μ/ml) when compared with controls (2.3±0.2μg/ml), and LF output in NCP (12.3±3.8 μg/min) was increased from controls (3.8±0.6 μg/min). The combination of high LF concentration with low protein output was observed in 10/14 in CCP but 0/14 in NCP and can be a biochemical discriminator of CCP from NCP. SC concentrations were also elevated in NCP (8.5±2.0 μg/ml) and CCP (5.6±1.6 μg/ml) from controls (1.2±0.2 μg/ml). SC outputs in SCP (9.8±3.1 μg/min) and NCP (21.1±4.8 μg/min) were increased from controls (1.7±0.3 μg/min), but there was no further increase in CCP. Hypersecretion of LF and SC in chronic pancreatitis is different, especially in CCP, although the mechanisms for hypersecretion are unknown. More... »

PAGES

7-11

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01296766

DOI

http://dx.doi.org/10.1007/bf01296766

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047159037

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7678385


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