Serum immunoreactive elastase in diagnosis of pancreatic diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-01

AUTHORS

Hirotsugu Hamano, Tetsuo Hayakawa, Takaharu Kondo

ABSTRACT

Diagnostic significance of serum immunoreactive elastase-1 was studied in 137 patients with pancreatic disease, 335 with various nonpancreatic diseases, and 416 healthy controls by using radioimmunoassay. Frequency of abnormally high serum elastase values exceeding 410 ng/dl was 100% in acute pancreatitis (N=14), 40% in chronic pancreatitis (N=80), and 72% in pancreatic cancer (N=43). In pancreatic cancer the mean value of serum elastase in resectable cancer (N=19) was significantly higher than that in unresectable cancer (N=24). Sensitivity, specificity, and efficiency of serum elastase in pancreatic cancer were 72.1%, 98.3%, and 95.9% against healthy controls; 72.1%, 85.9%, and 83.6% against nonpancreatic digestive diseases; and 72.1%, 60.0%, and 64.2% against chronic pancreatitis at a cutoff level of 410 ng/dl, respectively. High serum elastase could be a diagnostic clue to detect pancreatic duct obstruction due to pancreatic cancer, although further examination should be done by endoscopic retrograde pancreatography and other imaging studies. More... »

PAGES

50-56

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01296687

DOI

http://dx.doi.org/10.1007/bf01296687

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017943840

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2431845


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