Cell cycle analysis of tumour-derived cultures ofCrepis capillaris: A kinetic analogy with proliferation of animal tumour cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-09

AUTHORS

Sarah E. Ashmore, A. R. Gould

ABSTRACT

Analysis of the cell cycle by three methods has revealed unusual kinetics of proliferation in tumour derived suspensions ofCrepis capillaris. The different methods of analysis yield different estimates of cycle phase durations, and such discrepancies have been explained in terms of low growth fractions with rapid total cycle traverse. Specifically, confidence in the estimation of G2 duration by the fraction of labelled mitosis analysis, and comparison with shorter G2 estimates obtained by the two other methods, suggests that cells drop out in G1. However, cells which do not drop out of the proliferative compartment traverse G1 extremely rapidly. Extremely short cell cycle durations in which the G1 phase is virtually non-existent are uncharacteristic of plant cell suspension cultures, in which the G1 phase has previously been shown to be extended as compared with meristematic root tip cells. A model has been proposed in which a central core of rapidly dividing cells continuously loses cells into a subpopulation of resting or G0 cells with the G1 DNA content. Similarities between plant and animal tumours with respect to cell growth and division are discussed. More... »

PAGES

217-230

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01281573

DOI

http://dx.doi.org/10.1007/bf01281573

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026897177

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/538268


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0607", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Plant Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interphase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metaphase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Tumors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plants", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Genetics Department, Research School of Biological Sciences, The Australian National University, P.O. Box 475, A.C.T. 2601, Canberra City, Canberra, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1001.0", 
          "name": [
            "Genetics Department, Research School of Biological Sciences, The Australian National University, P.O. Box 475, A.C.T. 2601, Canberra City, Canberra, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ashmore", 
        "givenName": "Sarah E.", 
        "id": "sg:person.0722214650.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722214650.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetics Department, Research School of Biological Sciences, The Australian National University, P.O. Box 475, A.C.T. 2601, Canberra City, Canberra, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1001.0", 
          "name": [
            "Genetics Department, Research School of Biological Sciences, The Australian National University, P.O. Box 475, A.C.T. 2601, Canberra City, Canberra, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gould", 
        "givenName": "A. R.", 
        "id": "sg:person.01371016234.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371016234.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/2091115a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047655151", 
          "https://doi.org/10.1038/2091115a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00399725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028161914", 
          "https://doi.org/10.1007/bf00399725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00525557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017276205", 
          "https://doi.org/10.1007/bf00525557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00394431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005159714", 
          "https://doi.org/10.1007/bf00394431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/277129a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032852748", 
          "https://doi.org/10.1038/277129a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1979-09", 
    "datePublishedReg": "1979-09-01", 
    "description": "Analysis of the cell cycle by three methods has revealed unusual kinetics of proliferation in tumour derived suspensions ofCrepis capillaris. The different methods of analysis yield different estimates of cycle phase durations, and such discrepancies have been explained in terms of low growth fractions with rapid total cycle traverse. Specifically, confidence in the estimation of G2 duration by the fraction of labelled mitosis analysis, and comparison with shorter G2 estimates obtained by the two other methods, suggests that cells drop out in G1. However, cells which do not drop out of the proliferative compartment traverse G1 extremely rapidly. Extremely short cell cycle durations in which the G1 phase is virtually non-existent are uncharacteristic of plant cell suspension cultures, in which the G1 phase has previously been shown to be extended as compared with meristematic root tip cells. A model has been proposed in which a central core of rapidly dividing cells continuously loses cells into a subpopulation of resting or G0 cells with the G1 DNA content. Similarities between plant and animal tumours with respect to cell growth and division are discussed.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01281573", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1118135", 
        "issn": [
          "0033-183X", 
          "1615-6102"
        ], 
        "name": "Protoplasma", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "101"
      }
    ], 
    "keywords": [
      "meristematic root tip cells", 
      "plant cell suspension cultures", 
      "G1 phase", 
      "root tip cells", 
      "shorter cell cycle duration", 
      "cell suspension cultures", 
      "G1 DNA content", 
      "cell cycle duration", 
      "tip cells", 
      "cell cycle", 
      "G0 cells", 
      "cell cycle analysis", 
      "animal tumor cells", 
      "suspension cultures", 
      "cell growth", 
      "DNA content", 
      "cycle phase durations", 
      "cycle traverse", 
      "capillaris", 
      "G2 duration", 
      "cells", 
      "mitosis analysis", 
      "cycle analysis", 
      "proliferation", 
      "G1", 
      "tumor cells", 
      "plants", 
      "unusual kinetics", 
      "cycle duration", 
      "division", 
      "central core", 
      "low growth fraction", 
      "similarity", 
      "growth", 
      "analysis", 
      "subpopulations", 
      "animal tumors", 
      "cycle", 
      "phase duration", 
      "fraction", 
      "culture", 
      "different estimates", 
      "tumors", 
      "growth fraction", 
      "resting", 
      "content", 
      "such discrepancies", 
      "kinetics", 
      "estimates", 
      "phase", 
      "different methods", 
      "duration", 
      "traverse", 
      "comparison", 
      "core", 
      "analogy", 
      "respect", 
      "method", 
      "model", 
      "discrepancy", 
      "terms", 
      "confidence", 
      "estimation", 
      "kinetic analogy", 
      "suspensions ofCrepis capillaris", 
      "ofCrepis capillaris", 
      "rapid total cycle traverse", 
      "total cycle traverse", 
      "shorter G2 estimates", 
      "G2 estimates", 
      "proliferative compartment traverse G1", 
      "compartment traverse G1", 
      "traverse G1", 
      "subpopulation of resting", 
      "tumour-derived cultures ofCrepis capillaris", 
      "cultures ofCrepis capillaris"
    ], 
    "name": "Cell cycle analysis of tumour-derived cultures ofCrepis capillaris: A kinetic analogy with proliferation of animal tumour cells", 
    "pagination": "217-230", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026897177"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01281573"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "538268"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01281573", 
      "https://app.dimensions.ai/details/publication/pub.1026897177"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_130.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01281573"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01281573'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01281573'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01281573'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01281573'


 

This table displays all metadata directly associated to this object as RDF triples.

196 TRIPLES      21 PREDICATES      115 URIs      101 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01281573 schema:about N05740a30c1624ebb88c6a14957bc3290
2 N50256903068444e1803acde028c4e81f
3 N6178d105257143349a27ddcd6d38263b
4 N77604e1ef79d45ae8f730888b18b44d8
5 N90acd8c2e366427f8d8deafc29bb8d34
6 Nd211c5e010574e35ac44ee3ff243fc10
7 Nf5fdaeacf5984f629ebe1898e236cad2
8 anzsrc-for:06
9 anzsrc-for:0601
10 anzsrc-for:0607
11 schema:author N8b94c0252ea846aa820a1ddc5a96a292
12 schema:citation sg:pub.10.1007/bf00394431
13 sg:pub.10.1007/bf00399725
14 sg:pub.10.1007/bf00525557
15 sg:pub.10.1038/2091115a0
16 sg:pub.10.1038/277129a0
17 schema:datePublished 1979-09
18 schema:datePublishedReg 1979-09-01
19 schema:description Analysis of the cell cycle by three methods has revealed unusual kinetics of proliferation in tumour derived suspensions ofCrepis capillaris. The different methods of analysis yield different estimates of cycle phase durations, and such discrepancies have been explained in terms of low growth fractions with rapid total cycle traverse. Specifically, confidence in the estimation of G2 duration by the fraction of labelled mitosis analysis, and comparison with shorter G2 estimates obtained by the two other methods, suggests that cells drop out in G1. However, cells which do not drop out of the proliferative compartment traverse G1 extremely rapidly. Extremely short cell cycle durations in which the G1 phase is virtually non-existent are uncharacteristic of plant cell suspension cultures, in which the G1 phase has previously been shown to be extended as compared with meristematic root tip cells. A model has been proposed in which a central core of rapidly dividing cells continuously loses cells into a subpopulation of resting or G0 cells with the G1 DNA content. Similarities between plant and animal tumours with respect to cell growth and division are discussed.
20 schema:genre article
21 schema:isAccessibleForFree false
22 schema:isPartOf N8bf935db9be4417d93cc51c33bb76694
23 Nd9de69b9207b48f4b1d57c626a9ef229
24 sg:journal.1118135
25 schema:keywords DNA content
26 G0 cells
27 G1
28 G1 DNA content
29 G1 phase
30 G2 duration
31 G2 estimates
32 analogy
33 analysis
34 animal tumor cells
35 animal tumors
36 capillaris
37 cell cycle
38 cell cycle analysis
39 cell cycle duration
40 cell growth
41 cell suspension cultures
42 cells
43 central core
44 comparison
45 compartment traverse G1
46 confidence
47 content
48 core
49 culture
50 cultures ofCrepis capillaris
51 cycle
52 cycle analysis
53 cycle duration
54 cycle phase durations
55 cycle traverse
56 different estimates
57 different methods
58 discrepancy
59 division
60 duration
61 estimates
62 estimation
63 fraction
64 growth
65 growth fraction
66 kinetic analogy
67 kinetics
68 low growth fraction
69 meristematic root tip cells
70 method
71 mitosis analysis
72 model
73 ofCrepis capillaris
74 phase
75 phase duration
76 plant cell suspension cultures
77 plants
78 proliferation
79 proliferative compartment traverse G1
80 rapid total cycle traverse
81 respect
82 resting
83 root tip cells
84 shorter G2 estimates
85 shorter cell cycle duration
86 similarity
87 subpopulation of resting
88 subpopulations
89 such discrepancies
90 suspension cultures
91 suspensions ofCrepis capillaris
92 terms
93 tip cells
94 total cycle traverse
95 traverse
96 traverse G1
97 tumor cells
98 tumors
99 tumour-derived cultures ofCrepis capillaris
100 unusual kinetics
101 schema:name Cell cycle analysis of tumour-derived cultures ofCrepis capillaris: A kinetic analogy with proliferation of animal tumour cells
102 schema:pagination 217-230
103 schema:productId N08ea68d596da4953a7ee7adb67753af7
104 N5a986a7a38b74a67916f5963d8c2bf0d
105 Nac87dac578234d9d9aa8acdb32cf04e5
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026897177
107 https://doi.org/10.1007/bf01281573
108 schema:sdDatePublished 2022-01-01T18:00
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N633c8ef08d574019b30075140e85ccf1
111 schema:url https://doi.org/10.1007/bf01281573
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N05740a30c1624ebb88c6a14957bc3290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Kinetics
117 rdf:type schema:DefinedTerm
118 N08ea68d596da4953a7ee7adb67753af7 schema:name doi
119 schema:value 10.1007/bf01281573
120 rdf:type schema:PropertyValue
121 N50256903068444e1803acde028c4e81f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Plants
123 rdf:type schema:DefinedTerm
124 N5a986a7a38b74a67916f5963d8c2bf0d schema:name dimensions_id
125 schema:value pub.1026897177
126 rdf:type schema:PropertyValue
127 N6178d105257143349a27ddcd6d38263b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cell Cycle
129 rdf:type schema:DefinedTerm
130 N633c8ef08d574019b30075140e85ccf1 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N77604e1ef79d45ae8f730888b18b44d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Interphase
134 rdf:type schema:DefinedTerm
135 N8b94c0252ea846aa820a1ddc5a96a292 rdf:first sg:person.0722214650.29
136 rdf:rest N8f500208ce9240e88ebd61dd6b507e33
137 N8bf935db9be4417d93cc51c33bb76694 schema:volumeNumber 101
138 rdf:type schema:PublicationVolume
139 N8f500208ce9240e88ebd61dd6b507e33 rdf:first sg:person.01371016234.21
140 rdf:rest rdf:nil
141 N90acd8c2e366427f8d8deafc29bb8d34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Line
143 rdf:type schema:DefinedTerm
144 Nac87dac578234d9d9aa8acdb32cf04e5 schema:name pubmed_id
145 schema:value 538268
146 rdf:type schema:PropertyValue
147 Nd211c5e010574e35ac44ee3ff243fc10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Plant Tumors
149 rdf:type schema:DefinedTerm
150 Nd9de69b9207b48f4b1d57c626a9ef229 schema:issueNumber 3
151 rdf:type schema:PublicationIssue
152 Nf5fdaeacf5984f629ebe1898e236cad2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Metaphase
154 rdf:type schema:DefinedTerm
155 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
156 schema:name Biological Sciences
157 rdf:type schema:DefinedTerm
158 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
159 schema:name Biochemistry and Cell Biology
160 rdf:type schema:DefinedTerm
161 anzsrc-for:0607 schema:inDefinedTermSet anzsrc-for:
162 schema:name Plant Biology
163 rdf:type schema:DefinedTerm
164 sg:journal.1118135 schema:issn 0033-183X
165 1615-6102
166 schema:name Protoplasma
167 schema:publisher Springer Nature
168 rdf:type schema:Periodical
169 sg:person.01371016234.21 schema:affiliation grid-institutes:grid.1001.0
170 schema:familyName Gould
171 schema:givenName A. R.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371016234.21
173 rdf:type schema:Person
174 sg:person.0722214650.29 schema:affiliation grid-institutes:grid.1001.0
175 schema:familyName Ashmore
176 schema:givenName Sarah E.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722214650.29
178 rdf:type schema:Person
179 sg:pub.10.1007/bf00394431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005159714
180 https://doi.org/10.1007/bf00394431
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/bf00399725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028161914
183 https://doi.org/10.1007/bf00399725
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/bf00525557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017276205
186 https://doi.org/10.1007/bf00525557
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/2091115a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047655151
189 https://doi.org/10.1038/2091115a0
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/277129a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032852748
192 https://doi.org/10.1038/277129a0
193 rdf:type schema:CreativeWork
194 grid-institutes:grid.1001.0 schema:alternateName Genetics Department, Research School of Biological Sciences, The Australian National University, P.O. Box 475, A.C.T. 2601, Canberra City, Canberra, Australia
195 schema:name Genetics Department, Research School of Biological Sciences, The Australian National University, P.O. Box 475, A.C.T. 2601, Canberra City, Canberra, Australia
196 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...