Antiparkinsonian effect of flupirtine in monoamine-depleted rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

M. Schwarz, M. Nolden-Koch, J. Purr, G. Pergande, F. Block

ABSTRACT

Excitatory amino acid receptor antagonists lead to marked suppression of parkinsonian-like symptoms in rodent and primate models of Parkinson's disease and are able to potentiate the ability of L-DOPA to reverse akinesia and ameliorate muscular rigidity displayed in these animal models. Flupirtine, which is clinically used as a non-opioid analgesic agent, has some N-methyl-D-aspartate (NMDA) antagonistic properties in several in vivo and in vitro experiments. We now report that in monoamine depleted rats (pretreated with reserpine, 5 mg/kg, and alpha-methyl-para-tyrosine, 250 mg/ kg i.p.) flupirtine dose-dependently (1-20 mg/kg i.p.) suppressed rigidity, measured as tonic EMG activity in the gastrocnemius muscle, but had no effect on akinesia, measured as locomotor activity. In addition, it potentiated the antiparkinsonian effect of L-DOPA on akinesia and rigidity in this rodent model of Parkinson's disease. These effects of flupirtine are of particular clinical relevance, since flupirtine is devoid of the typical side effects of NMDA-receptor antagonists. More... »

PAGES

581-590

References to SciGraph publications

  • 1991-09. Synergism of the AMPA-antagonist NBQX and the NMDA-antagonist CPP with L-Dopa in models of Parkinson's disease in JOURNAL OF NEURAL TRANSMISSION: PARKINSON'S DISEASE A AND DEMENTIA SECTION
  • 1980-08. Opioid receptors in the caudate nucleus can mediate EMG-recorded rigidity in rats in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1989-10. The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice in ACTA NEUROVEGETATIVA
  • 1993-04. Flupirtine in DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01273155

    DOI

    http://dx.doi.org/10.1007/bf01273155

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024239706

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8811503


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aminopyridines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Analgesics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antiparkinson Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biogenic Monoamines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Synergism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Electromyography", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Levodopa", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuroprotective Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Parkinson Disease, Secondary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats, Wistar", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "RWTH Aachen University", 
              "id": "https://www.grid.ac/institutes/grid.1957.a", 
              "name": [
                "Department of Neurology, Technical University, Aachen"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schwarz", 
            "givenName": "M.", 
            "id": "sg:person.01037467035.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037467035.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "RWTH Aachen University", 
              "id": "https://www.grid.ac/institutes/grid.1957.a", 
              "name": [
                "Department of Neurology, Technical University, Aachen"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nolden-Koch", 
            "givenName": "M.", 
            "id": "sg:person.016140041074.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016140041074.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "RWTH Aachen University", 
              "id": "https://www.grid.ac/institutes/grid.1957.a", 
              "name": [
                "Department of Neurology, Technical University, Aachen"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Purr", 
            "givenName": "J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ASTA Medica Germany, Frankfurt, Federal Republic of Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pergande", 
            "givenName": "G.", 
            "id": "sg:person.0621134340.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621134340.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "RWTH Aachen University", 
              "id": "https://www.grid.ac/institutes/grid.1957.a", 
              "name": [
                "Department of Neurology, Technical University, Aachen"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Block", 
            "givenName": "F.", 
            "id": "sg:person.01113572452.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113572452.60"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0014-2999(95)00043-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000095689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.34.5.616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001782246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(95)00570-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003278719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.50.1.66", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004790322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-199412000-00056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006231108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-199412000-00056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006231108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410280411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007024308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(93)90595-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007921983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(93)90595-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007921983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02259538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008710569", 
              "https://doi.org/10.1007/bf02259538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02259538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008710569", 
              "https://doi.org/10.1007/bf02259538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-199410000-00036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010503319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-199410000-00036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010503319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-199410000-00036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010503319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00498570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018170481", 
              "https://doi.org/10.1007/bf00498570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00498570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018170481", 
              "https://doi.org/10.1007/bf00498570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0924-980x(95)00049-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023436552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(74)90067-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026780320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(74)90067-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026780320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(89)90120-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029856074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(89)90120-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029856074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bja/55.5.429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030574060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(91)90585-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032690612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(91)90585-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032690612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410340413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035253190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410350605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036124285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0922-4106(94)90006-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037429604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0922-4106(94)90006-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037429604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-199345040-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037973634", 
              "https://doi.org/10.2165/00003495-199345040-00007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(94)91510-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042503360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(94)91510-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042503360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0091-3057(89)90007-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046009294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0091-3057(89)90007-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046009294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01258633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046144017", 
              "https://doi.org/10.1007/bf01258633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01258633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046144017", 
              "https://doi.org/10.1007/bf01258633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(87)90738-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047706521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(87)90738-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047706521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.870060208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048208653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-6147(93)90005-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052421619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-6147(93)90005-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052421619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2402638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062536328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075756056", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076078545", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076278669", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076753895", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078533620", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082876893", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1996-05", 
        "datePublishedReg": "1996-05-01", 
        "description": "Excitatory amino acid receptor antagonists lead to marked suppression of parkinsonian-like symptoms in rodent and primate models of Parkinson's disease and are able to potentiate the ability of L-DOPA to reverse akinesia and ameliorate muscular rigidity displayed in these animal models. Flupirtine, which is clinically used as a non-opioid analgesic agent, has some N-methyl-D-aspartate (NMDA) antagonistic properties in several in vivo and in vitro experiments. We now report that in monoamine depleted rats (pretreated with reserpine, 5 mg/kg, and alpha-methyl-para-tyrosine, 250 mg/ kg i.p.) flupirtine dose-dependently (1-20 mg/kg i.p.) suppressed rigidity, measured as tonic EMG activity in the gastrocnemius muscle, but had no effect on akinesia, measured as locomotor activity. In addition, it potentiated the antiparkinsonian effect of L-DOPA on akinesia and rigidity in this rodent model of Parkinson's disease. These effects of flupirtine are of particular clinical relevance, since flupirtine is devoid of the typical side effects of NMDA-receptor antagonists.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf01273155", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1312227", 
            "issn": [
              "0300-9564", 
              "1435-1463"
            ], 
            "name": "Journal of Neural Transmission", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "103"
          }
        ], 
        "name": "Antiparkinsonian effect of flupirtine in monoamine-depleted rats", 
        "pagination": "581-590", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "737b46d52e9629429fca0e70bbf3ec012ff56fed6daf9f925e6e1646f2b172cd"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8811503"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9702341"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf01273155"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024239706"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf01273155", 
          "https://app.dimensions.ai/details/publication/pub.1024239706"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:32", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46760_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/BF01273155"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01273155'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01273155'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01273155'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01273155'


     

    This table displays all metadata directly associated to this object as RDF triples.

    244 TRIPLES      21 PREDICATES      74 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf01273155 schema:about N0233539a28244543b258d99f14f6f959
    2 N1b4ded5cdfbd4c9d908de408c2a15b6b
    3 N4cf7230a291241a9b3d253c514e6186d
    4 N64339522a236405ba1ab41fecde4b6bb
    5 N7e6f117de4014d889d1ffb2179a3c599
    6 Na194cac35f8d4a848fdb3bb4330d6e9f
    7 Na34cf45faf494fe5a47b97adbcbd4c51
    8 Na8f1392577644828bb3db5f5c4fe2de1
    9 Nabb306dd45d04b6dba95ce84680a5ed5
    10 Nae9818c5654649d9a29e97e9fdaeb1c3
    11 Nc69e0e38453c43b6a10c926db322cb10
    12 Nd01aeffe3607453994995d335cbf3703
    13 Nef6f6e1bf467485d8274a76ace050ade
    14 anzsrc-for:11
    15 anzsrc-for:1109
    16 schema:author N5bf57a2b39e544208ebd2f8d7058307c
    17 schema:citation sg:pub.10.1007/bf00498570
    18 sg:pub.10.1007/bf01258633
    19 sg:pub.10.1007/bf02259538
    20 sg:pub.10.2165/00003495-199345040-00007
    21 https://app.dimensions.ai/details/publication/pub.1075756056
    22 https://app.dimensions.ai/details/publication/pub.1076078545
    23 https://app.dimensions.ai/details/publication/pub.1076278669
    24 https://app.dimensions.ai/details/publication/pub.1076753895
    25 https://app.dimensions.ai/details/publication/pub.1078533620
    26 https://app.dimensions.ai/details/publication/pub.1082876893
    27 https://doi.org/10.1002/ana.410280411
    28 https://doi.org/10.1002/ana.410340413
    29 https://doi.org/10.1002/ana.410350605
    30 https://doi.org/10.1002/mds.870060208
    31 https://doi.org/10.1016/0006-8993(91)90585-j
    32 https://doi.org/10.1016/0006-8993(94)91510-5
    33 https://doi.org/10.1016/0014-2999(74)90067-3
    34 https://doi.org/10.1016/0014-2999(87)90738-2
    35 https://doi.org/10.1016/0014-2999(95)00043-k
    36 https://doi.org/10.1016/0014-2999(95)00570-6
    37 https://doi.org/10.1016/0091-3057(89)90007-5
    38 https://doi.org/10.1016/0165-6147(93)90005-5
    39 https://doi.org/10.1016/0306-4522(89)90120-6
    40 https://doi.org/10.1016/0306-4522(93)90595-7
    41 https://doi.org/10.1016/0922-4106(94)90006-x
    42 https://doi.org/10.1016/0924-980x(95)00049-q
    43 https://doi.org/10.1093/bja/55.5.429
    44 https://doi.org/10.1097/00001756-199410000-00036
    45 https://doi.org/10.1097/00001756-199412000-00056
    46 https://doi.org/10.1126/science.2402638
    47 https://doi.org/10.1136/jnnp.34.5.616
    48 https://doi.org/10.1136/jnnp.50.1.66
    49 schema:datePublished 1996-05
    50 schema:datePublishedReg 1996-05-01
    51 schema:description Excitatory amino acid receptor antagonists lead to marked suppression of parkinsonian-like symptoms in rodent and primate models of Parkinson's disease and are able to potentiate the ability of L-DOPA to reverse akinesia and ameliorate muscular rigidity displayed in these animal models. Flupirtine, which is clinically used as a non-opioid analgesic agent, has some N-methyl-D-aspartate (NMDA) antagonistic properties in several in vivo and in vitro experiments. We now report that in monoamine depleted rats (pretreated with reserpine, 5 mg/kg, and alpha-methyl-para-tyrosine, 250 mg/ kg i.p.) flupirtine dose-dependently (1-20 mg/kg i.p.) suppressed rigidity, measured as tonic EMG activity in the gastrocnemius muscle, but had no effect on akinesia, measured as locomotor activity. In addition, it potentiated the antiparkinsonian effect of L-DOPA on akinesia and rigidity in this rodent model of Parkinson's disease. These effects of flupirtine are of particular clinical relevance, since flupirtine is devoid of the typical side effects of NMDA-receptor antagonists.
    52 schema:genre research_article
    53 schema:inLanguage en
    54 schema:isAccessibleForFree false
    55 schema:isPartOf Nd271d476edb244e9aa479e2c42af3ae1
    56 Nd58653c6388348af8106ff78499a96bd
    57 sg:journal.1312227
    58 schema:name Antiparkinsonian effect of flupirtine in monoamine-depleted rats
    59 schema:pagination 581-590
    60 schema:productId N7481458e90544269b388e9857702d707
    61 N8ab6f61adf454a9ead748f9bf918b967
    62 N8e8219aff4df4ca98ee488586fd53ea5
    63 N9b5eb13dab754ac19a210bbf4643b768
    64 Ncc6b1656ba504662990ea7a667ae0baa
    65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024239706
    66 https://doi.org/10.1007/bf01273155
    67 schema:sdDatePublished 2019-04-11T13:32
    68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    69 schema:sdPublisher N4a2a0fd6448f4cdfa4370ca11cd97ea2
    70 schema:url http://link.springer.com/10.1007/BF01273155
    71 sgo:license sg:explorer/license/
    72 sgo:sdDataset articles
    73 rdf:type schema:ScholarlyArticle
    74 N0233539a28244543b258d99f14f6f959 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    75 schema:name Rats
    76 rdf:type schema:DefinedTerm
    77 N1b4ded5cdfbd4c9d908de408c2a15b6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    78 schema:name Rats, Wistar
    79 rdf:type schema:DefinedTerm
    80 N41127f67b3fd45d1acadf378632d054a rdf:first sg:person.016140041074.21
    81 rdf:rest N6eb691d3373c4aafb57fdbb96efaa496
    82 N4a2a0fd6448f4cdfa4370ca11cd97ea2 schema:name Springer Nature - SN SciGraph project
    83 rdf:type schema:Organization
    84 N4cf7230a291241a9b3d253c514e6186d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Drug Synergism
    86 rdf:type schema:DefinedTerm
    87 N5970333fb9ec441b8ce4001d253ec62c rdf:first sg:person.01113572452.60
    88 rdf:rest rdf:nil
    89 N5bf57a2b39e544208ebd2f8d7058307c rdf:first sg:person.01037467035.49
    90 rdf:rest N41127f67b3fd45d1acadf378632d054a
    91 N64339522a236405ba1ab41fecde4b6bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Analgesics
    93 rdf:type schema:DefinedTerm
    94 N6cc153af3f1c40feb57f8bbaed3a3300 schema:name ASTA Medica Germany, Frankfurt, Federal Republic of Germany
    95 rdf:type schema:Organization
    96 N6eb691d3373c4aafb57fdbb96efaa496 rdf:first Nc298cf0ab99d4a89b30825f75625fb26
    97 rdf:rest N9418925671cc4028bb045abdb3d0c4d5
    98 N7481458e90544269b388e9857702d707 schema:name nlm_unique_id
    99 schema:value 9702341
    100 rdf:type schema:PropertyValue
    101 N7e6f117de4014d889d1ffb2179a3c599 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Levodopa
    103 rdf:type schema:DefinedTerm
    104 N8ab6f61adf454a9ead748f9bf918b967 schema:name pubmed_id
    105 schema:value 8811503
    106 rdf:type schema:PropertyValue
    107 N8e8219aff4df4ca98ee488586fd53ea5 schema:name doi
    108 schema:value 10.1007/bf01273155
    109 rdf:type schema:PropertyValue
    110 N9418925671cc4028bb045abdb3d0c4d5 rdf:first sg:person.0621134340.11
    111 rdf:rest N5970333fb9ec441b8ce4001d253ec62c
    112 N9b5eb13dab754ac19a210bbf4643b768 schema:name dimensions_id
    113 schema:value pub.1024239706
    114 rdf:type schema:PropertyValue
    115 Na194cac35f8d4a848fdb3bb4330d6e9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Aminopyridines
    117 rdf:type schema:DefinedTerm
    118 Na34cf45faf494fe5a47b97adbcbd4c51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Neuroprotective Agents
    120 rdf:type schema:DefinedTerm
    121 Na8f1392577644828bb3db5f5c4fe2de1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Electromyography
    123 rdf:type schema:DefinedTerm
    124 Nabb306dd45d04b6dba95ce84680a5ed5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Antiparkinson Agents
    126 rdf:type schema:DefinedTerm
    127 Nae9818c5654649d9a29e97e9fdaeb1c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Animals
    129 rdf:type schema:DefinedTerm
    130 Nc298cf0ab99d4a89b30825f75625fb26 schema:affiliation https://www.grid.ac/institutes/grid.1957.a
    131 schema:familyName Purr
    132 schema:givenName J.
    133 rdf:type schema:Person
    134 Nc69e0e38453c43b6a10c926db322cb10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Biogenic Monoamines
    136 rdf:type schema:DefinedTerm
    137 Ncc6b1656ba504662990ea7a667ae0baa schema:name readcube_id
    138 schema:value 737b46d52e9629429fca0e70bbf3ec012ff56fed6daf9f925e6e1646f2b172cd
    139 rdf:type schema:PropertyValue
    140 Nd01aeffe3607453994995d335cbf3703 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Male
    142 rdf:type schema:DefinedTerm
    143 Nd271d476edb244e9aa479e2c42af3ae1 schema:issueNumber 5
    144 rdf:type schema:PublicationIssue
    145 Nd58653c6388348af8106ff78499a96bd schema:volumeNumber 103
    146 rdf:type schema:PublicationVolume
    147 Nef6f6e1bf467485d8274a76ace050ade schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Parkinson Disease, Secondary
    149 rdf:type schema:DefinedTerm
    150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    151 schema:name Medical and Health Sciences
    152 rdf:type schema:DefinedTerm
    153 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    154 schema:name Neurosciences
    155 rdf:type schema:DefinedTerm
    156 sg:journal.1312227 schema:issn 0300-9564
    157 1435-1463
    158 schema:name Journal of Neural Transmission
    159 rdf:type schema:Periodical
    160 sg:person.01037467035.49 schema:affiliation https://www.grid.ac/institutes/grid.1957.a
    161 schema:familyName Schwarz
    162 schema:givenName M.
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037467035.49
    164 rdf:type schema:Person
    165 sg:person.01113572452.60 schema:affiliation https://www.grid.ac/institutes/grid.1957.a
    166 schema:familyName Block
    167 schema:givenName F.
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113572452.60
    169 rdf:type schema:Person
    170 sg:person.016140041074.21 schema:affiliation https://www.grid.ac/institutes/grid.1957.a
    171 schema:familyName Nolden-Koch
    172 schema:givenName M.
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016140041074.21
    174 rdf:type schema:Person
    175 sg:person.0621134340.11 schema:affiliation N6cc153af3f1c40feb57f8bbaed3a3300
    176 schema:familyName Pergande
    177 schema:givenName G.
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621134340.11
    179 rdf:type schema:Person
    180 sg:pub.10.1007/bf00498570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018170481
    181 https://doi.org/10.1007/bf00498570
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/bf01258633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046144017
    184 https://doi.org/10.1007/bf01258633
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/bf02259538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008710569
    187 https://doi.org/10.1007/bf02259538
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.2165/00003495-199345040-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037973634
    190 https://doi.org/10.2165/00003495-199345040-00007
    191 rdf:type schema:CreativeWork
    192 https://app.dimensions.ai/details/publication/pub.1075756056 schema:CreativeWork
    193 https://app.dimensions.ai/details/publication/pub.1076078545 schema:CreativeWork
    194 https://app.dimensions.ai/details/publication/pub.1076278669 schema:CreativeWork
    195 https://app.dimensions.ai/details/publication/pub.1076753895 schema:CreativeWork
    196 https://app.dimensions.ai/details/publication/pub.1078533620 schema:CreativeWork
    197 https://app.dimensions.ai/details/publication/pub.1082876893 schema:CreativeWork
    198 https://doi.org/10.1002/ana.410280411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007024308
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1002/ana.410340413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035253190
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1002/ana.410350605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036124285
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1002/mds.870060208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048208653
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/0006-8993(91)90585-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1032690612
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/0006-8993(94)91510-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042503360
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/0014-2999(74)90067-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026780320
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/0014-2999(87)90738-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047706521
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/0014-2999(95)00043-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1000095689
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/0014-2999(95)00570-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003278719
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/0091-3057(89)90007-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046009294
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/0165-6147(93)90005-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052421619
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/0306-4522(89)90120-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029856074
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/0306-4522(93)90595-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007921983
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/0922-4106(94)90006-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037429604
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/0924-980x(95)00049-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1023436552
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1093/bja/55.5.429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030574060
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1097/00001756-199410000-00036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010503319
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1097/00001756-199412000-00056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006231108
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1126/science.2402638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062536328
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1136/jnnp.34.5.616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001782246
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1136/jnnp.50.1.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004790322
    241 rdf:type schema:CreativeWork
    242 https://www.grid.ac/institutes/grid.1957.a schema:alternateName RWTH Aachen University
    243 schema:name Department of Neurology, Technical University, Aachen
    244 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...