Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch N-Nitroso-1,3-bis-(2-chloroethyl)-harnstoff (BCNU) auf das in das Colon descendens der ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-12

AUTHORS

M. Lorenz, E. Biwer, M. Habs, D. Schmähl

ABSTRACT

There are numerous reports on in vitro and in vivo investigations of hyperthermia for cytostasis of malignant tumors. Combination of chemotherapy and hyperthermia is to potentiate the therapeutic effect. The time interval between the two types of therapy was the main subject of the present investigation. Local hyperthermia (43°C, 60 min) following BCNU chemotherapy at intervals of 0, 3, 6, 9, 12, and 24 h, respectively, was studied in a colonic Yoshida sarcoma model in Sprague-Dawley rats. No significant increase in the curing rate resulted from hyperthermic treatment. The results suggest that the highly anticipated hyperthermic peritoneal lavages should be investigated in controlled animal experiments prior to clinical use. More... »

PAGES

253-261

References to SciGraph publications

  • 1973-04. Hyperthermia (42°C) as an Adjuvant to Radiotherapy and Chemotherapy in the Treatment of the Allogeneic VX2 Carcinoma in the Rabbit in BRITISH JOURNAL OF CANCER
  • 1980. New Anticancer Drugs in NONE
  • 1976-01. Some new congeners of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) synthesis of bifunctional analogs and water soluble derivatives and preliminary evaluation of their chemotherapeutic potential in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 1983-11. Intraperitoneal approach to regional hyperthermia—possible anticancer applications in WORLD JOURNAL OF SURGERY
  • 1976-10. In vivo hyperthermia of Yoshida tumour induces entry of non-proliferating cells into cycle in NATURE
  • 1980-01. Effect of misonidazole and hyperthermia on the radiosensitivity of a C3H mouse mammary carcinoma and its surrounding normal tissue in BRITISH JOURNAL OF CANCER
  • 1977-01. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples in BRITISH JOURNAL OF CANCER
  • 1979-01. Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on yoshida sarcoma ascites cells implanted into the colon wall of rats in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 1983-09. Effect of moderate local hyperthermia combined with chemotherapy by administration of cyclophosphamide or N-Nitroso-1,3-bis(2-chloroethyl)urea (BCNU) on Yoshida Sarcoma Implanted in the descending colon of rats in LANGENBECK'S ARCHIVES OF SURGERY
  • 1974-02-01. Editorial: Guidelines on the analysis of tumour rates and death rates in experimental animals in BRITISH JOURNAL OF CANCER
  • 1967-12. Extrem-Hyperthermie-Versuche bei vier verschiedenen Tumoren von Ratten in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 1981-10. Antitumor activity of new nitrosoureas on Yoshida sarcoma ascites cells implanted into the colon wall of rats in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01254653

    DOI

    http://dx.doi.org/10.1007/bf01254653

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043337330

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6503501


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