Imaging of dopamine transporters in humans with technetium-99m TRODAT 1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-11

AUTHORS

Hank F. Kung, Hee-Joung Kim, Mei-Ping Kung, Sanath K. Meegalla, Karl Plössl, Hee-Kyung Lee

ABSTRACT

Technetium-99m TRODAT-1, a tropane derivative, has shown promise as a tracer for the imaging of dopamine transporters in preliminary studies in rats and baboons. The present report concerns the first study of the use of [99mTc]TRODAT-1 for the same purpose in humans. The specific uptake of [99mTc]TRODAT-1 in dopamine transporter sites located in the basal ganglia area was confirmed: the best contrast between the basal ganglia and the occipital area, which is devoid of dopamine transporters, was achieved at 120-140 min following injection. The development of a 99mTc-based agent bypasses the need for cyclotron-produced radionuclides, which will be of benefit for routine clinical studies. More... »

PAGES

1527-1530

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01254479

DOI

http://dx.doi.org/10.1007/bf01254479

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026914665

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8854853


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