A clinical study on the relationship between the pineal gland and the opioid system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-03

AUTHORS

P. Lissoni, D. Esposti, G. Esposti, R. Mauri, M. Resentini, F. Morabito, P. Fumagalli, A. Santagostino, G. Delitala, F. Fraschini

ABSTRACT

Recent reports point to a link between the pineal gland and the opioid system. In order to investigate this relationship, two separate studies were performed on humans. Beta-endorphin plasma levels were determined after melatonin administration (0.2 mg/kg b.w. i.m. at 2 p.m.). Melatonin serum values were evaluated after administration of FK 33-824, a met-enkephalin analogue (0.3 mg i.v. infusion at 9 a.m.). A significant decrease of beta-endorphin plasma levels was observed 120 minutes after melatonin injection. Melatonin release was stimulated by FK 33-824, with a peak at 30 minutes. The present results provide evidence of the inhibitory effect of melatonin on beta-endorphin secretion and the stimulatory action of the opioid peptides on the pineal gland. However, further studies will be required to clarify the relationship between the opioid system and the pineal gland. More... »

PAGES

63-73

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01249612

DOI

http://dx.doi.org/10.1007/bf01249612

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025753056

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2937880


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47 schema:description Recent reports point to a link between the pineal gland and the opioid system. In order to investigate this relationship, two separate studies were performed on humans. Beta-endorphin plasma levels were determined after melatonin administration (0.2 mg/kg b.w. i.m. at 2 p.m.). Melatonin serum values were evaluated after administration of FK 33-824, a met-enkephalin analogue (0.3 mg i.v. infusion at 9 a.m.). A significant decrease of beta-endorphin plasma levels was observed 120 minutes after melatonin injection. Melatonin release was stimulated by FK 33-824, with a peak at 30 minutes. The present results provide evidence of the inhibitory effect of melatonin on beta-endorphin secretion and the stimulatory action of the opioid peptides on the pineal gland. However, further studies will be required to clarify the relationship between the opioid system and the pineal gland.
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