Evaluation of gamma camera-based measurement of individual kidney function using iodine-123 orthoiodohippurate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-04

AUTHORS

Noboru Oriuchi, Tomio Inoue, Ikuko Hyashi, Sonoo Mizuiri, Noboru Kosaka, Junichi Nishikawa, Yasuhito Sasaki, Keigo Endo

ABSTRACT

Gamma camera-based clearance techniques which use the renal uptake ratio (RUR) of the radiotracer are available to estimate the effective renal plasma flow (ERPF) and glomerular filtration rate. To evaluate the accuracy of these techniques, we measured RUR by an optimized procedure and compared it with standard ER-PF. Iodine-123 orthoiodohippurate (OIH) scintigraphy and simultaneouspara-aminohippurate clearance study for measuring standard ERPF were performed in three hospitals in 24 patients with normal or mildly impaired renal function. 1231-OIH was injected intravenously and 10-s consecutive imaging of the kidneys was started when the abdominal aorta was seen. The attenuation coefficient for 1231 was measured in each hospital using the same water-equivalent absorption materials and used for the attenuation correction. After subtracting background radioactivity, RURs were defined as the count ratios of fractional renal uptakes based on the integral from 1 to 2, 2 to 3, 1.5 to 2.5 and 1 to 3 min after the injection of 1231-OIH in relation to injected doses using the following three procedures in respect of attenuation correction: (1) RUR without attenuation correction, (2) RUR with fractional renal uptake corrected by the measured attenuation coefficient, (3) RUR with the total injected dose corrected by the absorption material. To decide upon the appropriate correction method and time interval, RURs were compared with standard ERPF. Among the three correction methods, procedure 2 showed the highest correlation between RUR and standard ERPF, but the correlation coefficient was low (r=0.75). No significant difference was observed among the RURs of each time interval. Individual kidney function measured from early renal uptake may be inaccurate even when appropriate correction is made for attenuation, background activity or time lag between injection and data acquisition. Gamma camera-based measurement of renal function using123I-OIH is limited with regard to accuracy and reproducibility, though it is convenient and non-invasive. More... »

PAGES

371-375

References to SciGraph publications

  • 1982-02. New formulas for the calculation of effective renal plasma flow in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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    http://scigraph.springernature.com/pub.10.1007/bf01247363

    DOI

    http://dx.doi.org/10.1007/bf01247363

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009119144

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8612655


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