PET studies of dopamine receptor distribution using [18F]fluoroethylspiperone: findings in disorders related to the dopaminergic system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-10

AUTHORS

K. Wienhard, H. H. Coenen, G. Pawlik, J. Rudolf, P. Laufer, S. Jovkar, G. Stöcklin, W. -D. Heiss

ABSTRACT

PET studies of dopamine D2-receptor binding were performed in thirty patients with various disorders related to the dopaminergic system and in six healthy controls. Uptake of [18F]fluoroethylspiperone in caudate over three hours was analyzed in terms of several indices of receptor binding:caudate-to-cerebellum activity ratio, concentration of ligand as percentage of injected dose, caudate-to-blood radioactivity ratio, slope of tracer uptake curves, binding potential, kinetic constants of a three compartment model. In 14 patients brain glucose metabolism was also measured. Data on medicated patients demonstrate that the average values of most of the above parameters indicate the decreased number of available D2-receptors whereby, besides an age dependent decline, the caudate-to-cerebellum ratio affords the relatively best distinction among diagnostic groups. In individual cases, large variability among subjects permits only the classification of severe pathologies. Morphological damage and neuronal loss in the striatum may also cause abnormal low values both for the indices of receptor binding and for glucose consumption, thus providing a possible pathogenetic link between receptor dysfunction and impaired energy metabolism. More... »

PAGES

195-213

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01245042

DOI

http://dx.doi.org/10.1007/bf01245042

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026457330

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2144427


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caudate Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nervous System Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parkinson Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine D2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizophrenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spiperone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr neurologische Forschung, K\u00f6ln"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wienhard", 
        "givenName": "K.", 
        "id": "sg:person.0747547562.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747547562.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Forschungszentrum J\u00fclich", 
          "id": "https://www.grid.ac/institutes/grid.8385.6", 
          "name": [
            "Institut f\u00fcr Chemie 1, Kernforschungsanlage J\u00fclich, J\u00fclich, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coenen", 
        "givenName": "H. H.", 
        "id": "sg:person.01342401277.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342401277.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr neurologische Forschung, K\u00f6ln"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pawlik", 
        "givenName": "G.", 
        "id": "sg:person.012010453704.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010453704.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr neurologische Forschung, K\u00f6ln"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rudolf", 
        "givenName": "J.", 
        "id": "sg:person.01067651236.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067651236.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Forschungszentrum J\u00fclich", 
          "id": "https://www.grid.ac/institutes/grid.8385.6", 
          "name": [
            "Institut f\u00fcr Chemie 1, Kernforschungsanlage J\u00fclich, J\u00fclich, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laufer", 
        "givenName": "P.", 
        "id": "sg:person.01256260257.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256260257.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr neurologische Forschung, K\u00f6ln"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jovkar", 
        "givenName": "S.", 
        "id": "sg:person.011471512440.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011471512440.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Forschungszentrum J\u00fclich", 
          "id": "https://www.grid.ac/institutes/grid.8385.6", 
          "name": [
            "Institut f\u00fcr Chemie 1, Kernforschungsanlage J\u00fclich, J\u00fclich, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "St\u00f6cklin", 
        "givenName": "G.", 
        "id": "sg:person.01324373457.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324373457.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Metabolism Research", 
          "id": "https://www.grid.ac/institutes/grid.418034.a", 
          "name": [
            "Max-Planck-Institut f\u00fcr neurologische Forschung, K\u00f6ln"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heiss", 
        "givenName": "W. -D.", 
        "id": "sg:person.014142346732.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014142346732.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000412790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000412790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001791964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001791964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(87)90255-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002177021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(87)90255-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002177021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.49.8.853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003544482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410120504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003883960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-3223(88)90048-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005526281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-3223(88)90048-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005526281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2897(86)90035-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012333849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00253446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012549766", 
          "https://doi.org/10.1007/bf00253446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00253446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012549766", 
          "https://doi.org/10.1007/bf00253446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1977.tb10649.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016554520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1988.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017572287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1988.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017572287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410060502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017761252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1984.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018135208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1984.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018135208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.1987.01800190091013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019234414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021721941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1986.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021721941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410150302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021962229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(84)90238-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023124392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(84)90238-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023124392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.44.1.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025521561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0317167100046369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031204213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(86)90003-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035077263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(86)90003-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035077263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1985.15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042978875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1985.15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042978875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-009-3345-3_20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044745244", 
          "https://doi.org/10.1007/978-94-009-3345-3_20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/305137a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049292542", 
          "https://doi.org/10.1038/305137a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-198402000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050708058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-198402000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050708058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.870010110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051323392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2878495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062568977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6334363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062636824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6604315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062639159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079647101", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081575401", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081659434", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-10", 
    "datePublishedReg": "1990-10-01", 
    "description": "PET studies of dopamine D2-receptor binding were performed in thirty patients with various disorders related to the dopaminergic system and in six healthy controls. Uptake of [18F]fluoroethylspiperone in caudate over three hours was analyzed in terms of several indices of receptor binding:caudate-to-cerebellum activity ratio, concentration of ligand as percentage of injected dose, caudate-to-blood radioactivity ratio, slope of tracer uptake curves, binding potential, kinetic constants of a three compartment model. In 14 patients brain glucose metabolism was also measured. Data on medicated patients demonstrate that the average values of most of the above parameters indicate the decreased number of available D2-receptors whereby, besides an age dependent decline, the caudate-to-cerebellum ratio affords the relatively best distinction among diagnostic groups. In individual cases, large variability among subjects permits only the classification of severe pathologies. Morphological damage and neuronal loss in the striatum may also cause abnormal low values both for the indices of receptor binding and for glucose consumption, thus providing a possible pathogenetic link between receptor dysfunction and impaired energy metabolism.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01245042", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1312204", 
        "issn": [
          "0300-9564", 
          "1435-1463"
        ], 
        "name": "Journal of Neural Transmission", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "81"
      }
    ], 
    "name": "PET studies of dopamine receptor distribution using [18F]fluoroethylspiperone: findings in disorders related to the dopaminergic system", 
    "pagination": "195-213", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7e0ac6298306c6be870dde10f6eb9233e41ac26fe5ffab289ecdc0301338d1ae"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2144427"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9002201"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01245042"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026457330"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01245042", 
      "https://app.dimensions.ai/details/publication/pub.1026457330"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000481.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF01245042"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01245042'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01245042'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01245042'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01245042'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      75 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01245042 schema:about N02327de20ce84ffebc4925bf82b819ec
2 N261c7415eedf4dd286c5c191b08ef5db
3 N2fdefb6ad3ed4cef8fa8e91baeb9729a
4 N40c3d958a03a46ad85cdae0c801a441a
5 N67d63a4dd990434db3d865c9ee2b6536
6 N6db77493cecd4ab9a4ba2285c15c5a92
7 N6fff8e1ba1ce421fa3139935a443a699
8 N70144285e13440269748df367062f99c
9 N74f8a804b49442ff8a2590543cc657d5
10 N874c8e0222f4471790e8038d4b1e9551
11 N93c0b9f0d99e476f9d65bb460aae9e18
12 Nac7c41baf6174ee9a7db2a6c03435e95
13 Nb34fb55ad6b04a64808b3f274472dbfa
14 Nbb44042a71ad4588aeffe4b25a42922a
15 Nbeca9b904d5041d6a11a6f81fa86e31f
16 Nf0b6018a4bc44af6ad5b38191e707dab
17 anzsrc-for:11
18 anzsrc-for:1109
19 schema:author N9e8612805c564d80adbfccee8da190ac
20 schema:citation sg:pub.10.1007/978-94-009-3345-3_20
21 sg:pub.10.1007/bf00253446
22 sg:pub.10.1038/305137a0
23 https://app.dimensions.ai/details/publication/pub.1079647101
24 https://app.dimensions.ai/details/publication/pub.1081575401
25 https://app.dimensions.ai/details/publication/pub.1081659434
26 https://doi.org/10.1001/archpsyc.1987.01800190091013
27 https://doi.org/10.1002/ana.410060502
28 https://doi.org/10.1002/ana.410120504
29 https://doi.org/10.1002/ana.410150302
30 https://doi.org/10.1002/mds.870010110
31 https://doi.org/10.1016/0006-3223(88)90048-0
32 https://doi.org/10.1016/0014-2999(84)90238-3
33 https://doi.org/10.1016/0024-3205(87)90255-4
34 https://doi.org/10.1016/0883-2889(86)90003-1
35 https://doi.org/10.1016/0883-2897(86)90035-8
36 https://doi.org/10.1017/s0317167100046369
37 https://doi.org/10.1038/jcbfm.1984.30
38 https://doi.org/10.1038/jcbfm.1985.15
39 https://doi.org/10.1038/jcbfm.1986.26
40 https://doi.org/10.1038/jcbfm.1986.29
41 https://doi.org/10.1038/jcbfm.1986.96
42 https://doi.org/10.1038/jcbfm.1988.64
43 https://doi.org/10.1097/00004728-198402000-00016
44 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x
45 https://doi.org/10.1126/science.2878495
46 https://doi.org/10.1126/science.6334363
47 https://doi.org/10.1126/science.6604315
48 https://doi.org/10.1136/jnnp.49.8.853
49 https://doi.org/10.1161/01.res.44.1.127
50 schema:datePublished 1990-10
51 schema:datePublishedReg 1990-10-01
52 schema:description PET studies of dopamine D2-receptor binding were performed in thirty patients with various disorders related to the dopaminergic system and in six healthy controls. Uptake of [18F]fluoroethylspiperone in caudate over three hours was analyzed in terms of several indices of receptor binding:caudate-to-cerebellum activity ratio, concentration of ligand as percentage of injected dose, caudate-to-blood radioactivity ratio, slope of tracer uptake curves, binding potential, kinetic constants of a three compartment model. In 14 patients brain glucose metabolism was also measured. Data on medicated patients demonstrate that the average values of most of the above parameters indicate the decreased number of available D2-receptors whereby, besides an age dependent decline, the caudate-to-cerebellum ratio affords the relatively best distinction among diagnostic groups. In individual cases, large variability among subjects permits only the classification of severe pathologies. Morphological damage and neuronal loss in the striatum may also cause abnormal low values both for the indices of receptor binding and for glucose consumption, thus providing a possible pathogenetic link between receptor dysfunction and impaired energy metabolism.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf N58a611aac76a4f338d3d8b2e39583499
57 N76f16d6b40004b06ad63a1c582d99c43
58 sg:journal.1312204
59 schema:name PET studies of dopamine receptor distribution using [18F]fluoroethylspiperone: findings in disorders related to the dopaminergic system
60 schema:pagination 195-213
61 schema:productId N230f72ac49d043728cae051c78e7a0d7
62 N512f640cc532437dafbaa7f608e01325
63 N5e285cb99c4e4c4f82f940e08d799137
64 N7fbeec4e664d43629448bc7297a56b31
65 N98f5808f336e48d19729e303eabac21b
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026457330
67 https://doi.org/10.1007/bf01245042
68 schema:sdDatePublished 2019-04-11T01:00
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher Ne3528fcc48794c01b2415b71e144e0db
71 schema:url http://link.springer.com/10.1007/BF01245042
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N02327de20ce84ffebc4925bf82b819ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Tomography, Emission-Computed
77 rdf:type schema:DefinedTerm
78 N18327b069f3c41f6b783e5e094c6e802 rdf:first sg:person.01256260257.36
79 rdf:rest Nd8c7a66419c04365a7e0ecafafac8a82
80 N230f72ac49d043728cae051c78e7a0d7 schema:name pubmed_id
81 schema:value 2144427
82 rdf:type schema:PropertyValue
83 N261c7415eedf4dd286c5c191b08ef5db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Spiperone
85 rdf:type schema:DefinedTerm
86 N2fdefb6ad3ed4cef8fa8e91baeb9729a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Adolescent
88 rdf:type schema:DefinedTerm
89 N40c3d958a03a46ad85cdae0c801a441a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Receptors, Dopamine D2
91 rdf:type schema:DefinedTerm
92 N512f640cc532437dafbaa7f608e01325 schema:name dimensions_id
93 schema:value pub.1026457330
94 rdf:type schema:PropertyValue
95 N556dff7158b84a469f62c304e26b79e5 rdf:first sg:person.014142346732.64
96 rdf:rest rdf:nil
97 N58a611aac76a4f338d3d8b2e39583499 schema:volumeNumber 81
98 rdf:type schema:PublicationVolume
99 N5e285cb99c4e4c4f82f940e08d799137 schema:name doi
100 schema:value 10.1007/bf01245042
101 rdf:type schema:PropertyValue
102 N64eb86b570724e9d89ce315576012ab1 rdf:first sg:person.01067651236.52
103 rdf:rest N18327b069f3c41f6b783e5e094c6e802
104 N67d63a4dd990434db3d865c9ee2b6536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Receptors, Dopamine
106 rdf:type schema:DefinedTerm
107 N6db77493cecd4ab9a4ba2285c15c5a92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Middle Aged
109 rdf:type schema:DefinedTerm
110 N6fff8e1ba1ce421fa3139935a443a699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Schizophrenia
112 rdf:type schema:DefinedTerm
113 N70144285e13440269748df367062f99c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Female
115 rdf:type schema:DefinedTerm
116 N74f8a804b49442ff8a2590543cc657d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Male
118 rdf:type schema:DefinedTerm
119 N76f16d6b40004b06ad63a1c582d99c43 schema:issueNumber 3
120 rdf:type schema:PublicationIssue
121 N7fbeec4e664d43629448bc7297a56b31 schema:name nlm_unique_id
122 schema:value 9002201
123 rdf:type schema:PropertyValue
124 N874c8e0222f4471790e8038d4b1e9551 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Brain
126 rdf:type schema:DefinedTerm
127 N93c0b9f0d99e476f9d65bb460aae9e18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Nervous System Diseases
129 rdf:type schema:DefinedTerm
130 N98f5808f336e48d19729e303eabac21b schema:name readcube_id
131 schema:value 7e0ac6298306c6be870dde10f6eb9233e41ac26fe5ffab289ecdc0301338d1ae
132 rdf:type schema:PropertyValue
133 N9e8612805c564d80adbfccee8da190ac rdf:first sg:person.0747547562.15
134 rdf:rest Na626150df09b4898a7a5021301ae44b9
135 Na626150df09b4898a7a5021301ae44b9 rdf:first sg:person.01342401277.27
136 rdf:rest Ne29aaea88f8d4a3e815a8d092c728295
137 Nac7c41baf6174ee9a7db2a6c03435e95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Aged
139 rdf:type schema:DefinedTerm
140 Nb34fb55ad6b04a64808b3f274472dbfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adult
142 rdf:type schema:DefinedTerm
143 Nbb44042a71ad4588aeffe4b25a42922a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Caudate Nucleus
145 rdf:type schema:DefinedTerm
146 Nbeca9b904d5041d6a11a6f81fa86e31f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Parkinson Disease
148 rdf:type schema:DefinedTerm
149 Nd8c7a66419c04365a7e0ecafafac8a82 rdf:first sg:person.011471512440.26
150 rdf:rest Ne1bf225c93ee46e39d645850b05f5e53
151 Ne1bf225c93ee46e39d645850b05f5e53 rdf:first sg:person.01324373457.25
152 rdf:rest N556dff7158b84a469f62c304e26b79e5
153 Ne29aaea88f8d4a3e815a8d092c728295 rdf:first sg:person.012010453704.67
154 rdf:rest N64eb86b570724e9d89ce315576012ab1
155 Ne3528fcc48794c01b2415b71e144e0db schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 Nf0b6018a4bc44af6ad5b38191e707dab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
164 schema:name Neurosciences
165 rdf:type schema:DefinedTerm
166 sg:journal.1312204 schema:issn 0300-9564
167 1435-1463
168 schema:name Journal of Neural Transmission
169 rdf:type schema:Periodical
170 sg:person.01067651236.52 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
171 schema:familyName Rudolf
172 schema:givenName J.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067651236.52
174 rdf:type schema:Person
175 sg:person.011471512440.26 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
176 schema:familyName Jovkar
177 schema:givenName S.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011471512440.26
179 rdf:type schema:Person
180 sg:person.012010453704.67 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
181 schema:familyName Pawlik
182 schema:givenName G.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010453704.67
184 rdf:type schema:Person
185 sg:person.01256260257.36 schema:affiliation https://www.grid.ac/institutes/grid.8385.6
186 schema:familyName Laufer
187 schema:givenName P.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256260257.36
189 rdf:type schema:Person
190 sg:person.01324373457.25 schema:affiliation https://www.grid.ac/institutes/grid.8385.6
191 schema:familyName Stöcklin
192 schema:givenName G.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324373457.25
194 rdf:type schema:Person
195 sg:person.01342401277.27 schema:affiliation https://www.grid.ac/institutes/grid.8385.6
196 schema:familyName Coenen
197 schema:givenName H. H.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342401277.27
199 rdf:type schema:Person
200 sg:person.014142346732.64 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
201 schema:familyName Heiss
202 schema:givenName W. -D.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014142346732.64
204 rdf:type schema:Person
205 sg:person.0747547562.15 schema:affiliation https://www.grid.ac/institutes/grid.418034.a
206 schema:familyName Wienhard
207 schema:givenName K.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747547562.15
209 rdf:type schema:Person
210 sg:pub.10.1007/978-94-009-3345-3_20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044745244
211 https://doi.org/10.1007/978-94-009-3345-3_20
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/bf00253446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012549766
214 https://doi.org/10.1007/bf00253446
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/305137a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049292542
217 https://doi.org/10.1038/305137a0
218 rdf:type schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1079647101 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1081575401 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1081659434 schema:CreativeWork
222 https://doi.org/10.1001/archpsyc.1987.01800190091013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019234414
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/ana.410060502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017761252
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/ana.410120504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003883960
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/ana.410150302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021962229
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/mds.870010110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051323392
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0006-3223(88)90048-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005526281
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0014-2999(84)90238-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023124392
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0024-3205(87)90255-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002177021
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/0883-2889(86)90003-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035077263
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/0883-2897(86)90035-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012333849
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1017/s0317167100046369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031204213
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1038/jcbfm.1984.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018135208
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1038/jcbfm.1985.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042978875
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1038/jcbfm.1986.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001791964
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1038/jcbfm.1986.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000412790
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1038/jcbfm.1986.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021721941
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1038/jcbfm.1988.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017572287
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/00004728-198402000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050708058
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016554520
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1126/science.2878495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568977
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1126/science.6334363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062636824
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1126/science.6604315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639159
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1136/jnnp.49.8.853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003544482
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1161/01.res.44.1.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025521561
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.418034.a schema:alternateName Max Planck Institute for Metabolism Research
271 schema:name Max-Planck-Institut für neurologische Forschung, Köln
272 rdf:type schema:Organization
273 https://www.grid.ac/institutes/grid.8385.6 schema:alternateName Forschungszentrum Jülich
274 schema:name Institut für Chemie 1, Kernforschungsanlage Jülich, Jülich, Federal Republic of Germany
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...