Serum free insulin concentrations during the treatment of diabetic coma and precoma with low dose intramuscular insulin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1977-09

AUTHORS

C. M. Asplin, M. Hartog

ABSTRACT

Fifty patients in diabetic coma or precoma, 33 of whom had previously received insulin and had circulating insulin antibodies, were studied during treatment with a low-dose intramuscular insulin regime. In the presence of insulin antibodies, serum free insulin was separated from bound insulin by steady-state gel filtration. The initial mean serum free insulin concentration in the group of patients without insulin antibodies was 9 mU/1, 1 to 2 hours after intramuscular therapy it had risen to 22 mU/1, and after 7 to 8 hours to 73 mU/1. The corresponding concentrations for the group with insulin antibodies were 13, 23 and 74 mU/1. No relationship was found between the concentrations of serum free insulin attained and the age of the patients, their initial degree of acidosis, dehydration, and systolic blood pressure, the insulin antibody characteristics of their sera, nor the rate of decline of the blood glucose. More... »

PAGES

475-480

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01234499

DOI

http://dx.doi.org/10.1007/bf01234499

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024133613

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/908471


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