Measurements of insulin activities in pancreas and serum of mice with spontaneous (“obese” and “New Zealand obese”) and induced (goldthioglucose) ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1967-04

AUTHORS

Werner Stauffacher, André E. Lambert, Danièle Vecchio, Albert E. Renold

ABSTRACT

Summary1. Insulin-like activity (ILA) and immunoreactive insulin (IRI) of pancreatic extracts and of serum have been measured in lean and obese (obob) mice from the Jackson Memorial Laboratory in Bar Harbor, Maine; in New Zealand obese mice; and in goldthioglucose-obese Swiss mice, and their lean controls. In all three types of mice the relative amounts of “suppressible” and “nonsuppressible” insulin activities of serum have also been established. — 2. Pancreatic content of IRI in (obob) mice is much greater than in their lean sibblings at five months of age, but smaller at 5 weeks, whereas serum IRI and ILA of (obob) mice are greatly in excess of the same activities of serum from their lean littermates at both ages. It is suggested that increased peripheral demand for insulin preceeds increased insulin synthesis and storage in this type of obesity. — 3. In all three strains of mice, obese or lean, the ratio of biologic to immunologic activity of pancreatic extracts was constant and close to unity. In serum, this ratio was also constant but approximately five times greater than unity. These findings do not support the notion that differences in insulin structure might account for differences in the biological activity of insulin in obese and non-obese animals; they are in keeping with the concept of a potentiation of serum insulin activity by some component of serum in all mice. — 4. Approximately 90% of serum ILA in all three types of obese mice studied was suppressed in the presence of anti-insulin serum, although the absolute levels of non-suppressible ILA were similar to those reported for other species. It is unlikely, therefore, that “bound” insulin accounts for a significant part of the increased ILA of serum of any of the three types of obese animals studied. — 5. Present data support the concept of a marked tissue-bound muscular resistance to insulin action as an important, possibly primary pathogenetic feature in (obob) mice. A similar, but much less marked muscular resistance can be demonstrated in NZO mice, whereas muscular resistance to insulin action is totally absent in goldthioglucose obese Swiss mice after a 24 hour fast. More... »

PAGES

230-237

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01222200

DOI

http://dx.doi.org/10.1007/bf01222200

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008898908

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5630191


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diaphragm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gold", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperglycemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreas", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radioimmunoassay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfur", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8591.5", 
          "name": [
            "Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stauffacher", 
        "givenName": "Werner", 
        "id": "sg:person.046365767.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.046365767.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8591.5", 
          "name": [
            "Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lambert", 
        "givenName": "Andr\u00e9 E.", 
        "id": "sg:person.013544734142.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013544734142.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8591.5", 
          "name": [
            "Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vecchio", 
        "givenName": "Dani\u00e8le", 
        "id": "sg:person.0113117221.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113117221.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8591.5", 
          "name": [
            "Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Renold", 
        "givenName": "Albert E.", 
        "id": "sg:person.056013751.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056013751.89"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01257907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029302711", 
          "https://doi.org/10.1007/bf01257907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/184061a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017228129", 
          "https://doi.org/10.1038/184061a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1967-04", 
    "datePublishedReg": "1967-04-01", 
    "description": "Summary1. Insulin-like activity (ILA) and immunoreactive insulin (IRI) of pancreatic extracts and of serum have been measured in lean and obese (obob) mice from the Jackson Memorial Laboratory in Bar Harbor, Maine; in New Zealand obese mice; and in goldthioglucose-obese Swiss mice, and their lean controls. In all three types of mice the relative amounts of \u201csuppressible\u201d and \u201cnonsuppressible\u201d insulin activities of serum have also been established. \u2014 2. Pancreatic content of IRI in (obob) mice is much greater than in their lean sibblings at five months of age, but smaller at 5 weeks, whereas serum IRI and ILA of (obob) mice are greatly in excess of the same activities of serum from their lean littermates at both ages. It is suggested that increased peripheral demand for insulin preceeds increased insulin synthesis and storage in this type of obesity. \u2014 3. In all three strains of mice, obese or lean, the ratio of biologic to immunologic activity of pancreatic extracts was constant and close to unity. In serum, this ratio was also constant but approximately five times greater than unity. These findings do not support the notion that differences in insulin structure might account for differences in the biological activity of insulin in obese and non-obese animals; they are in keeping with the concept of a potentiation of serum insulin activity by some component of serum in all mice. \u2014 4. Approximately 90% of serum ILA in all three types of obese mice studied was suppressed in the presence of anti-insulin serum, although the absolute levels of non-suppressible ILA were similar to those reported for other species. It is unlikely, therefore, that \u201cbound\u201d insulin accounts for a significant part of the increased ILA of serum of any of the three types of obese animals studied. \u2014 5. Present data support the concept of a marked tissue-bound muscular resistance to insulin action as an important, possibly primary pathogenetic feature in (obob) mice. A similar, but much less marked muscular resistance can be demonstrated in NZO mice, whereas muscular resistance to insulin action is totally absent in goldthioglucose obese Swiss mice after a 24 hour fast.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01222200", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "keywords": [
      "insulin-like activity", 
      "immunoreactive insulin", 
      "obese mice", 
      "insulin activity", 
      "muscular resistance", 
      "Swiss mice", 
      "insulin action", 
      "New Zealand obese (NZO) mice", 
      "serum insulin-like activity", 
      "obese Swiss mice", 
      "type of obesity", 
      "serum immunoreactive insulin", 
      "serum of mice", 
      "pancreatic extracts", 
      "types of mice", 
      "non-obese animals", 
      "strains of mice", 
      "months of age", 
      "non-suppressible insulin-like activity", 
      "anti-insulin serum", 
      "spontaneous syndrome", 
      "NZO mice", 
      "lean controls", 
      "pathogenetic features", 
      "lean littermates", 
      "immunologic activity", 
      "obese animals", 
      "pancreatic content", 
      "insulin synthesis", 
      "mice", 
      "components of serum", 
      "insulin", 
      "serum", 
      "peripheral demand", 
      "obesity", 
      "present data", 
      "age", 
      "absolute levels", 
      "animals", 
      "obese", 
      "hyperglycemia", 
      "Bar Harbor", 
      "syndrome", 
      "activity", 
      "pathogenesis", 
      "littermates", 
      "pancreas", 
      "potentiation", 
      "biological activity", 
      "months", 
      "weeks", 
      "biologics", 
      "extract", 
      "same activity", 
      "resistance", 
      "action", 
      "hours", 
      "findings", 
      "types", 
      "relative amounts", 
      "levels", 
      "differences", 
      "control", 
      "ratio", 
      "strains", 
      "presence", 
      "insulin structure", 
      "laboratory", 
      "data", 
      "time", 
      "excess", 
      "features", 
      "part", 
      "amount", 
      "consideration", 
      "components", 
      "significant part", 
      "measurements", 
      "content", 
      "synthesis", 
      "concept", 
      "species", 
      "Maine", 
      "storage", 
      "demand", 
      "notion", 
      "structure", 
      "Harbor", 
      "unity"
    ], 
    "name": "Measurements of insulin activities in pancreas and serum of mice with spontaneous (\u201cobese\u201d and \u201cNew Zealand obese\u201d) and induced (goldthioglucose) obesity and hyperglycemia, with considerations on the pathogenesis of the spontaneous syndrome", 
    "pagination": "230-237", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008898908"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01222200"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "5630191"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01222200", 
      "https://app.dimensions.ai/details/publication/pub.1008898908"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_101.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01222200"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01222200'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01222200'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01222200'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01222200'


 

This table displays all metadata directly associated to this object as RDF triples.

251 TRIPLES      21 PREDICATES      135 URIs      125 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01222200 schema:about N039b35f125d94150ae0498affd2aa449
2 N069012d25a4c4a098b2f174a340dd56b
3 N083fef43368d40bcbfb6b0fb1b012456
4 N0be6a92190004ec99314d27535a9f4a4
5 N1120a22a449144b892887e22e95e7e31
6 N269e81068a0542a9b4be94906646ef4f
7 N3506605019974f8da53f50c51b4ebdcc
8 N422b269a01fc422f8bd675f4933d0742
9 N56feba7555d14e0082015764a743dd66
10 N6d4e28479fb3447daba77063831e298b
11 N6ed8e76c65284662a5ccff1b1bc9c873
12 N73ba47a885464450abcb441cb6916a15
13 N84cc324250ce48e8b5773f96a8f34099
14 N956407a8d72f47d4823702e8c0fb3e54
15 N9ed9d428f0634b5ba9bdb6ddf67cbf40
16 Nbf2869627344403ca4f3b08edf324269
17 Ncf70bc293f174ed9ad342c56811d0f94
18 Nf0ef86ab61864a97978ccd1393b0d9e2
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N64c849da300448808f2321dcb23cc010
22 schema:citation sg:pub.10.1007/bf01257907
23 sg:pub.10.1038/184061a0
24 schema:datePublished 1967-04
25 schema:datePublishedReg 1967-04-01
26 schema:description Summary1. Insulin-like activity (ILA) and immunoreactive insulin (IRI) of pancreatic extracts and of serum have been measured in lean and obese (obob) mice from the Jackson Memorial Laboratory in Bar Harbor, Maine; in New Zealand obese mice; and in goldthioglucose-obese Swiss mice, and their lean controls. In all three types of mice the relative amounts of “suppressible” and “nonsuppressible” insulin activities of serum have also been established. — 2. Pancreatic content of IRI in (obob) mice is much greater than in their lean sibblings at five months of age, but smaller at 5 weeks, whereas serum IRI and ILA of (obob) mice are greatly in excess of the same activities of serum from their lean littermates at both ages. It is suggested that increased peripheral demand for insulin preceeds increased insulin synthesis and storage in this type of obesity. — 3. In all three strains of mice, obese or lean, the ratio of biologic to immunologic activity of pancreatic extracts was constant and close to unity. In serum, this ratio was also constant but approximately five times greater than unity. These findings do not support the notion that differences in insulin structure might account for differences in the biological activity of insulin in obese and non-obese animals; they are in keeping with the concept of a potentiation of serum insulin activity by some component of serum in all mice. — 4. Approximately 90% of serum ILA in all three types of obese mice studied was suppressed in the presence of anti-insulin serum, although the absolute levels of non-suppressible ILA were similar to those reported for other species. It is unlikely, therefore, that “bound” insulin accounts for a significant part of the increased ILA of serum of any of the three types of obese animals studied. — 5. Present data support the concept of a marked tissue-bound muscular resistance to insulin action as an important, possibly primary pathogenetic feature in (obob) mice. A similar, but much less marked muscular resistance can be demonstrated in NZO mice, whereas muscular resistance to insulin action is totally absent in goldthioglucose obese Swiss mice after a 24 hour fast.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf N0529cd1e39424b75bf7d75c70c3fcb63
30 N29575dbbaf214fd594886cac8e28e123
31 sg:journal.1001482
32 schema:keywords Bar Harbor
33 Harbor
34 Maine
35 NZO mice
36 New Zealand obese (NZO) mice
37 Swiss mice
38 absolute levels
39 action
40 activity
41 age
42 amount
43 animals
44 anti-insulin serum
45 biological activity
46 biologics
47 components
48 components of serum
49 concept
50 consideration
51 content
52 control
53 data
54 demand
55 differences
56 excess
57 extract
58 features
59 findings
60 hours
61 hyperglycemia
62 immunologic activity
63 immunoreactive insulin
64 insulin
65 insulin action
66 insulin activity
67 insulin structure
68 insulin synthesis
69 insulin-like activity
70 laboratory
71 lean controls
72 lean littermates
73 levels
74 littermates
75 measurements
76 mice
77 months
78 months of age
79 muscular resistance
80 non-obese animals
81 non-suppressible insulin-like activity
82 notion
83 obese
84 obese Swiss mice
85 obese animals
86 obese mice
87 obesity
88 pancreas
89 pancreatic content
90 pancreatic extracts
91 part
92 pathogenesis
93 pathogenetic features
94 peripheral demand
95 potentiation
96 presence
97 present data
98 ratio
99 relative amounts
100 resistance
101 same activity
102 serum
103 serum immunoreactive insulin
104 serum insulin-like activity
105 serum of mice
106 significant part
107 species
108 spontaneous syndrome
109 storage
110 strains
111 strains of mice
112 structure
113 syndrome
114 synthesis
115 time
116 type of obesity
117 types
118 types of mice
119 unity
120 weeks
121 schema:name Measurements of insulin activities in pancreas and serum of mice with spontaneous (“obese” and “New Zealand obese”) and induced (goldthioglucose) obesity and hyperglycemia, with considerations on the pathogenesis of the spontaneous syndrome
122 schema:pagination 230-237
123 schema:productId N4b0cd2e74a344909985c2ccf6b723764
124 N92b72f336ba64ccbb6d6650b776c7662
125 Nac1330deca544f63ad3f22cb13199ac8
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008898908
127 https://doi.org/10.1007/bf01222200
128 schema:sdDatePublished 2022-11-24T20:44
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N5243ff99a36c4371ba15a275360ee881
131 schema:url https://doi.org/10.1007/bf01222200
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N039b35f125d94150ae0498affd2aa449 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Animals
137 rdf:type schema:DefinedTerm
138 N0529cd1e39424b75bf7d75c70c3fcb63 schema:issueNumber 2
139 rdf:type schema:PublicationIssue
140 N069012d25a4c4a098b2f174a340dd56b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Insulin Resistance
142 rdf:type schema:DefinedTerm
143 N083fef43368d40bcbfb6b0fb1b012456 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Hyperglycemia
145 rdf:type schema:DefinedTerm
146 N0be6a92190004ec99314d27535a9f4a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 N1120a22a449144b892887e22e95e7e31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Mice
151 rdf:type schema:DefinedTerm
152 N269e81068a0542a9b4be94906646ef4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Glucose
154 rdf:type schema:DefinedTerm
155 N29575dbbaf214fd594886cac8e28e123 schema:volumeNumber 3
156 rdf:type schema:PublicationVolume
157 N3506605019974f8da53f50c51b4ebdcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Diaphragm
159 rdf:type schema:DefinedTerm
160 N3af7bdc8200e4ca6aab70630a353e1b9 rdf:first sg:person.0113117221.11
161 rdf:rest Nff2287fb7e304af7a51a1340df167618
162 N422b269a01fc422f8bd675f4933d0742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Gold
164 rdf:type schema:DefinedTerm
165 N4b0cd2e74a344909985c2ccf6b723764 schema:name doi
166 schema:value 10.1007/bf01222200
167 rdf:type schema:PropertyValue
168 N5243ff99a36c4371ba15a275360ee881 schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 N56feba7555d14e0082015764a743dd66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Obesity
172 rdf:type schema:DefinedTerm
173 N64c849da300448808f2321dcb23cc010 rdf:first sg:person.046365767.45
174 rdf:rest Ne02848cdd8314ae5b8ca0ed0f30e6010
175 N6d4e28479fb3447daba77063831e298b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Rats
177 rdf:type schema:DefinedTerm
178 N6ed8e76c65284662a5ccff1b1bc9c873 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Species Specificity
180 rdf:type schema:DefinedTerm
181 N73ba47a885464450abcb441cb6916a15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Radioimmunoassay
183 rdf:type schema:DefinedTerm
184 N84cc324250ce48e8b5773f96a8f34099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Sulfur
186 rdf:type schema:DefinedTerm
187 N92b72f336ba64ccbb6d6650b776c7662 schema:name dimensions_id
188 schema:value pub.1008898908
189 rdf:type schema:PropertyValue
190 N956407a8d72f47d4823702e8c0fb3e54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Insulin
192 rdf:type schema:DefinedTerm
193 N9ed9d428f0634b5ba9bdb6ddf67cbf40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Pancreas
195 rdf:type schema:DefinedTerm
196 Nac1330deca544f63ad3f22cb13199ac8 schema:name pubmed_id
197 schema:value 5630191
198 rdf:type schema:PropertyValue
199 Nbf2869627344403ca4f3b08edf324269 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Male
201 rdf:type schema:DefinedTerm
202 Ncf70bc293f174ed9ad342c56811d0f94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Biological Assay
204 rdf:type schema:DefinedTerm
205 Ne02848cdd8314ae5b8ca0ed0f30e6010 rdf:first sg:person.013544734142.42
206 rdf:rest N3af7bdc8200e4ca6aab70630a353e1b9
207 Nf0ef86ab61864a97978ccd1393b0d9e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Adipose Tissue
209 rdf:type schema:DefinedTerm
210 Nff2287fb7e304af7a51a1340df167618 rdf:first sg:person.056013751.89
211 rdf:rest rdf:nil
212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
213 schema:name Medical and Health Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
216 schema:name Clinical Sciences
217 rdf:type schema:DefinedTerm
218 sg:journal.1001482 schema:issn 0012-186X
219 1432-0428
220 schema:name Diabetologia
221 schema:publisher Springer Nature
222 rdf:type schema:Periodical
223 sg:person.0113117221.11 schema:affiliation grid-institutes:grid.8591.5
224 schema:familyName Vecchio
225 schema:givenName Danièle
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113117221.11
227 rdf:type schema:Person
228 sg:person.013544734142.42 schema:affiliation grid-institutes:grid.8591.5
229 schema:familyName Lambert
230 schema:givenName André E.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013544734142.42
232 rdf:type schema:Person
233 sg:person.046365767.45 schema:affiliation grid-institutes:grid.8591.5
234 schema:familyName Stauffacher
235 schema:givenName Werner
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.046365767.45
237 rdf:type schema:Person
238 sg:person.056013751.89 schema:affiliation grid-institutes:grid.8591.5
239 schema:familyName Renold
240 schema:givenName Albert E.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056013751.89
242 rdf:type schema:Person
243 sg:pub.10.1007/bf01257907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029302711
244 https://doi.org/10.1007/bf01257907
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/184061a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017228129
247 https://doi.org/10.1038/184061a0
248 rdf:type schema:CreativeWork
249 grid-institutes:grid.8591.5 schema:alternateName Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland
250 schema:name Institut de Biochimie Clinique, University of Geneva, Geneva, Switzerland
251 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...