Studies on a diabetic (KK) strain of the mouse View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1967-04

AUTHORS

Mitsuo Nakamura, Kazuyori Yamada

ABSTRACT

This review demonstrates the following points:1. By glucose tolerance test and the determination of non-fasting blood sugar values, mice of KK strain (a Japanese strain) have been shown to be in a diabetic state. 2. KK mice have greater than normal body weights, and moderate obesity. 3. Pancreatic insulin activity and adenohypophyseal growth hormone content of KK mice are greater than those of C75BL mice. 4. The pancreas of KK mice presents many striking changes, such as the hypertrophy and hyperplasia of the islets, the hypertrophy and degranulation of B cells, the abundance of B cell ribosomes and endoplasmic reticulum, the enlargement of the Golgi areas of B cells, and the diminution of the zinc content of insular cells. 5. In other organs (eg. adenohypophysis, liver, adrenal and parathyroid) of KK mice, many changes are also observed. The above features of KK mice are discussed in relation to the presumed metabolic disorder in the mice. More... »

PAGES

212-221

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01222198

DOI

http://dx.doi.org/10.1007/bf01222198

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010446785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4907141


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