Determination of a fragment of the c-erbB-2 translational product p185 in serum of breast cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-05

AUTHORS

B. Kynast, L. Binder, D. Marx, B. Zoll, H. -J. Schmoll, M. Oellerich, A. Schauer

ABSTRACT

Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer patients showed serum concentrations up to 578 kU/l. All 9/70 patients with serum concentrations higher than 30 kU/l had clinical evidence of metastatic disease and the serum levels of all 35/70 patients without metastasis lay within the normal range. From 9/37 patients with p185 overexpression of the primary tumor in immunohistochemical analysis 3/9 patients with metastatic disease had elevated serum levels higher than 30 kU/l. In all, 6/9 patients without metastasis serum levels were below 30 kU/l. The data of the present study suggest that determination of serum p185 fragment concentrations may be useful as a diagnostic tool in postoperative follow-up of breast cancer patients with c-erbB-2 overexpression of the primary tumor. More... »

PAGES

249-252

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01212719

DOI

http://dx.doi.org/10.1007/bf01212719

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005157350

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8095050


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