Effects of H2-receptor antagonist and selective muscarinic receptor antagonist on early gastric stagnation after pylorus-preserving pancreaticoduodenectomy: Results of a randomized ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-10

AUTHORS

Tatsushi Iwagaki, Tadahiro Takada, Hideki Yasuda, Hisami Ando, Michio Asano

ABSTRACT

The suppressive effects of an H2-receptor antagonist, ranitidine, and a selective muscarinic receptor antagonist, pirenzepine, in improving gastric stasis during the early postoperative period after pylorus-preserving pancreaticoduodenectomy (PPPD) were assessed. Thirty-two PPPD patients were divided into four groups of 8 patients each. Group 1 served as controls and were given no medication. Group 2 received i.v. ranitidine alone, group 3 received i.v. pirenzepine alone, and group 4 received i.v. ranitidine and pirenzepine combined. The daily volume and the total acidity of the gastric juice, aspirated via a nasogastric tube, were measured on post-PPPD days 1–13. One patient in group 1 was withdrawn from this study due to severe gastric bleeding. The mean daily aspirated volume of gastric juice in group 1 (n=7) was 1043±362 ml on the 3rd postoperative day, and it gradually fell after the 5th postoperative day, but still exceeded 500 ml on day 13. In group 2 (n=8), the mean maximum volume, 614±251ml, was reached on the 4th postoperative day, and in group 3 (n=8), the mean maximum volume, 680 + 391 ml, was reached on the 3rd postoperative day. In contrast, in group 4 (n=8), the gastric juice output appeared to be suppressed and the mean maximum volume was 380±218 ml, this being reached on the 6th postoperative day. Gastric juice secretion was significantly higher in group 1 than in the other three groups (P<0.01). The total acidity was significantly lower in groups 3 and 4 than in group 1 (P<0.01). These results indicate that the postoperative administration of the combination of ranitidine and pirenzepine suppresses the volume and acidity of the gastric juice after a PPPD. More... »

PAGES

589-594

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01211926

DOI

http://dx.doi.org/10.1007/bf01211926

DIMENSIONS

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