Control of gastric pH with ranitidine in patients with Crohn's disease receiving total parenteral nutrition. Comparison of two intravenous regimens View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-01

AUTHORS

Toshiyuki Matsui, Akira Motomura, Masahide Arita, Yasumori Takeyama, Toshihiro Sakurai, Tsuneyoshi Yao

ABSTRACT

Eleven patients with Crohn's disease in remission who were receiving total parenteral nutrition (TPN) underwent continuous intragastric 24-h pH monitoring before and during ranitidine administration. The patients were randomly allocated to receive 200 mg/ day (group 1) or 400mg/day (group 2) of ranitidine by continuous infusion. The mean basal 24-h gastric pH was sustained at a low value. After raintidine administration, the mean pH increased significantly both in group 1 (from 2.13 to 3.28) and in group 2 (from 1.91 to 3.36), with the mean holding-time at pH-3 also increasing significantly in both groups. There were no differences in the mean pH or holding-time at pH-3 between the two groups during ranitidine administration; however, the plasma ranitidine concentration was significantly higher in group 2. These findings indicate that the continuous infusion of a standard dose of ranitidine exerted a maximal inhibitory effect on the sustained hyperacidity induced by TPN, but that this infusion was unable to maintain the intragastric pH level at above 3.5. More... »

PAGES

6-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01211180

DOI

http://dx.doi.org/10.1007/bf01211180

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041706701

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8808422


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