Ontology type: schema:ScholarlyArticle
1996-01
AUTHORSToshiyuki Matsui, Akira Motomura, Masahide Arita, Yasumori Takeyama, Toshihiro Sakurai, Tsuneyoshi Yao
ABSTRACTEleven patients with Crohn's disease in remission who were receiving total parenteral nutrition (TPN) underwent continuous intragastric 24-h pH monitoring before and during ranitidine administration. The patients were randomly allocated to receive 200 mg/ day (group 1) or 400mg/day (group 2) of ranitidine by continuous infusion. The mean basal 24-h gastric pH was sustained at a low value. After raintidine administration, the mean pH increased significantly both in group 1 (from 2.13 to 3.28) and in group 2 (from 1.91 to 3.36), with the mean holding-time at pH-3 also increasing significantly in both groups. There were no differences in the mean pH or holding-time at pH-3 between the two groups during ranitidine administration; however, the plasma ranitidine concentration was significantly higher in group 2. These findings indicate that the continuous infusion of a standard dose of ranitidine exerted a maximal inhibitory effect on the sustained hyperacidity induced by TPN, but that this infusion was unable to maintain the intragastric pH level at above 3.5. More... »
PAGES6-11
http://scigraph.springernature.com/pub.10.1007/bf01211180
DOIhttp://dx.doi.org/10.1007/bf01211180
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8808422
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