Effects of heavy ions on nucleic acids: Measurement of the damage View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-03

AUTHORS

J. Cadet, I. Girault, M. Gromova, D. Molko, F. Odin, M. Polverelli

ABSTRACT

In this short survey the main, available information on the molecular mechanisms of action of heavy ions on DNA is critically reviewed. Formation of single- and double-stranded DNA breaks in cells exposed to heavy particles is well established. On the other hand, base damage and, in a more general way, clustered lesions, whose formation should be increased upon exposure to heavy ions, have not yet been isolated and characterized. Efforts should be made to identify this important class of DNA damage in both isolated and cellular DNA. Sensitive and specific assays involving chemical and biochemical approaches have to be developed for such a purpose. More... »

PAGES

55-57

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01210547

DOI

http://dx.doi.org/10.1007/bf01210547

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016687970

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7604162


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