Synthesis of 1,4-dihydropyridines having an N-alkylpyridinium substituent at the 4-position and their affinity towards liposomal membranes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-08

AUTHORS

N. V. Makarova, Zh. V. Koronova, A. V. Plotnietse, D. Ya. Tirzite, G. D. Tirzit, G. Ya. Duburs

ABSTRACT

There has been synthesized a series of 1,4-dihydropyridines having an N-alkylpyridinium substituent at position 4 with a varying length of hydrocarbon chain. Their affinity to model (liposomal) membranes has been studied. It was found that this affinity increased with lengthening of the hydrocarbon chain on the Npyridinium substituent at the 4-position of the 1,4-dihydropyridine ring. However, lengthening of the hydrocarbon chain in the 3,5-ester groups of the 1, 4-dihydropyridine ring led to a decrease in the binding to the liposome when a 4-(N-hexadecylpyridinium) substituent was present. More... »

PAGES

969-973

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01170324

DOI

http://dx.doi.org/10.1007/bf01170324

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045410968


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