Sequence analysis of a PM2-DNA anti-Z-IgG-binding region View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-10

AUTHORS

F. D. Miller, R. J. Winkfein, J. B. Rattner, J. H. Van de Sande

ABSTRACT

An anti-Z-antibody-binding region between PM2-DNA map units 0.05 and 0.18, containing approx. 25% of the bound PM2 antibody molecules (1,2) has been sequenced. Analysis of this PM2 DNA sequence from map units 0.00 to 0.175 demonstrates that alternating purine/pyrimidine tracts capable of adopting the left-handed conformation are present within this antibody-binding region. Longer (GC)n-rich tracts are clustered together and comprise seven alternating purine/pyrimidine-rich areas (48%–84%) ranging from 19 to 142 nucleotides in length. The DNA located between these alternating purine/pyrimidine-rich areas exhibit a low level (0%–19%) of this sequence arrangement. There is a very strong correlation between the alternating purine/pyrimidine-rich areas and the anti-Z-DNA-IgG-binding sites. Nucleotides 1461–1583 of the PM2-DNA genome encode the bacteriophage capsid protein IV. One of the PM2 left-handed sites is located within this protein-coding sequence; a B-to-Z transition within this site may be involved in protein-IV gene regulation in vivo. More... »

PAGES

885-895

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01138171

DOI

http://dx.doi.org/10.1007/bf01138171

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045382674

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6518279


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