Short-term use of gonadotropin-releasing hormone agonist (Leuprolide) for in vitro fertilization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-12

AUTHORS

K. Paul Katayama, Mark Roesler, Cindy Gunnarson, Ed Stehlik, Susan Jagusch

ABSTRACT

A common problem encountered by in vitro fertilization (IVF) programs is the premature occurrence of the spontaneous luteinizing hormone (LH) surge during ovarian stimulation cycles. Administration of gonadotropin-releasing hormone agonists (GnRH-a) for 2 to 3 weeks produces a state of hypogonadotropic hypogonadism, thus allowing ovarian stimulation to proceed uncomplicated by a spontaneous LH surge. We have elected to treat seven patients with GnRH-a in a "short-term" protocol, with GnRH-a initiated on cycle day 3 along with exogenous gonadotropins. In this series, we found that the spontaneous LH surge was abolished, while ovarian responsiveness seemed to be improved. These results suggest that the initial surge of gonadotropins elicited by GnRH-a administration may enhance ovarian stimulation and that spontaneous LH surge is blocked when GnRH-a and exogenous gonadotropins are initiated concomitantly. More... »

PAGES

332-334

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01129568

DOI

http://dx.doi.org/10.1007/bf01129568

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027930756

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3146612


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