Tyrosinase activity in primary cell culture of amelanotic melanoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-11

AUTHORS

A. Słomiński, P. W. D. Scisłowski, A. Bomirski

ABSTRACT

After transfer of the Ab amelanotic melanoma cells from in vivo to in vitro growth conditons tyrosinase activity in their soluble fraction rapidly increased. This increase lasted to the middle of the logarithmic phase of growth and was followed by a decrease of tyrosinase activity , which was accompanied by accumulation of melanin in the cells. Calf serum stimulated simul-taneously tyrosinase activity, melanin synthesis, and proliferation of the melanoma ceils. Acrylamide-gel electrophoresis patterns of soluble tyrosinase from the Ab melanoma cells cultured in vitro consisted of two bands, similarly as soluble tyrosinase from the Ma melanotic melanoma cells freshly isolated from solid tumors. More... »

PAGES

1027-1034

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01121029

DOI

http://dx.doi.org/10.1007/bf01121029

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036512734

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6140964


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