L-Tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-10

AUTHORS

Andrzej Slominski, Pawel Jastreboff, John Pawelek

ABSTRACT

L-tyrosine, a precurosr to melanin, has recently been shown to be a regulator of the melanogenic pathway in some cultured melanoma cell lines. In this paper we demonstrated that L-tyrosine, besides increasing binding capacity for MSH, decreased cooperativity between MSH receptors and increased the level of tyrosinase induction by MSH. Apparently, regulation of MSH receptor activity by L-tyrosine involves specific changes in the interactions between the receptors and modification of the cellular responsiveness to MSH. More... »

PAGES

579-586

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01119801

DOI

http://dx.doi.org/10.1007/bf01119801

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039443275

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2508784


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catechol Oxidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetinae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Levodopa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanocyte-Stimulating Hormones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monophenol Monooxygenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Pituitary Hormone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Slominski", 
        "givenName": "Andrzej", 
        "id": "sg:person.016612034677.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612034677.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Surgery, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jastreboff", 
        "givenName": "Pawel", 
        "id": "sg:person.01173347004.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173347004.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pawelek", 
        "givenName": "John", 
        "id": "sg:person.01357521676.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357521676.69"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01122128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021084285", 
          "https://doi.org/10.1007/bf01122128"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1989-10", 
    "datePublishedReg": "1989-10-01", 
    "description": "L-tyrosine, a precurosr to melanin, has recently been shown to be a regulator of the melanogenic pathway in some cultured melanoma cell lines. In this paper we demonstrated that L-tyrosine, besides increasing binding capacity for MSH, decreased cooperativity between MSH receptors and increased the level of tyrosinase induction by MSH. Apparently, regulation of MSH receptor activity by L-tyrosine involves specific changes in the interactions between the receptors and modification of the cellular responsiveness to MSH.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01119801", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2465828", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682086", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092277", 
        "issn": [
          "0144-8463", 
          "1573-4935"
        ], 
        "name": "Bioscience Reports", 
        "publisher": "Portland Press", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "MSH receptors", 
      "MSH receptor activity", 
      "cultured melanoma cell lines", 
      "melanoma cell lines", 
      "hamster melanoma cells", 
      "receptor activity", 
      "melanoma cells", 
      "cellular responsiveness", 
      "L-tyrosine", 
      "receptors", 
      "cell lines", 
      "melanogenic pathway", 
      "MSH", 
      "tyrosinase activity", 
      "tyrosinase induction", 
      "specific changes", 
      "induction", 
      "cooperative interactions", 
      "responsiveness", 
      "activity", 
      "regulator", 
      "cells", 
      "pathway", 
      "regulation", 
      "cooperativity", 
      "levels", 
      "interaction", 
      "melanin", 
      "changes", 
      "lines", 
      "modification", 
      "capacity", 
      "paper"
    ], 
    "name": "L-Tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells", 
    "pagination": "579-586", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039443275"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01119801"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2508784"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01119801", 
      "https://app.dimensions.ai/details/publication/pub.1039443275"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_185.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01119801"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01119801'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01119801'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01119801'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01119801'


 

This table displays all metadata directly associated to this object as RDF triples.

166 TRIPLES      21 PREDICATES      72 URIs      63 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01119801 schema:about N159b53e7480b4f4284a010dd177c0942
2 N2bc8b63189294cf0bee31105aef0a1cc
3 N3f02608c6946438e8d0dae8599fc54f9
4 N69e12c17cc6b403eadff76b1eaeb305c
5 N7313207e4c7b4c34a39be0c177c9e8a4
6 N7bad803767d2472c9932ba2f423b5bab
7 N9bccd93b6aec44108499357384bd0e36
8 Nb17ab386b9d144bda9c4f7edddffbe6d
9 Nc7e8b19dcca6443494f04a5219cdab34
10 Nd2bd9c5567d24b21a591baf5a40dc19d
11 Ne3f76dcaa3824de6a405ab37bbb2e8c3
12 Ne83c5c97416141229aec90556cbff548
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author N797889fed9014293a45b7739d3f1f4e1
16 schema:citation sg:pub.10.1007/bf01122128
17 schema:datePublished 1989-10
18 schema:datePublishedReg 1989-10-01
19 schema:description L-tyrosine, a precurosr to melanin, has recently been shown to be a regulator of the melanogenic pathway in some cultured melanoma cell lines. In this paper we demonstrated that L-tyrosine, besides increasing binding capacity for MSH, decreased cooperativity between MSH receptors and increased the level of tyrosinase induction by MSH. Apparently, regulation of MSH receptor activity by L-tyrosine involves specific changes in the interactions between the receptors and modification of the cellular responsiveness to MSH.
20 schema:genre article
21 schema:isAccessibleForFree false
22 schema:isPartOf N2d83af43d48e4950a701b9835dc3dde7
23 Nc6589ca19b0c4b3f9a322b81dfb8b069
24 sg:journal.1092277
25 schema:keywords L-tyrosine
26 MSH
27 MSH receptor activity
28 MSH receptors
29 activity
30 capacity
31 cell lines
32 cells
33 cellular responsiveness
34 changes
35 cooperative interactions
36 cooperativity
37 cultured melanoma cell lines
38 hamster melanoma cells
39 induction
40 interaction
41 levels
42 lines
43 melanin
44 melanogenic pathway
45 melanoma cell lines
46 melanoma cells
47 modification
48 paper
49 pathway
50 receptor activity
51 receptors
52 regulation
53 regulator
54 responsiveness
55 specific changes
56 tyrosinase activity
57 tyrosinase induction
58 schema:name L-Tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells
59 schema:pagination 579-586
60 schema:productId N20b80ea69a774c1ea67e9fb87e0db5e4
61 N61dd44e4e9ba49e8b1cc329334ffe88f
62 Ne5fb7c3903b14bee9e8ac99b8da02894
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039443275
64 https://doi.org/10.1007/bf01119801
65 schema:sdDatePublished 2022-12-01T06:19
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N62afd556a4694864b55d98e252ae276a
68 schema:url https://doi.org/10.1007/bf01119801
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N159b53e7480b4f4284a010dd177c0942 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Cricetinae
74 rdf:type schema:DefinedTerm
75 N20b80ea69a774c1ea67e9fb87e0db5e4 schema:name dimensions_id
76 schema:value pub.1039443275
77 rdf:type schema:PropertyValue
78 N2bc8b63189294cf0bee31105aef0a1cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Tyrosine
80 rdf:type schema:DefinedTerm
81 N2d83af43d48e4950a701b9835dc3dde7 schema:volumeNumber 9
82 rdf:type schema:PublicationVolume
83 N3599a768250b4907b2c123f4d062ba9c rdf:first sg:person.01173347004.61
84 rdf:rest Nc0b44f7867bd4a29baf3c7efbafa99d0
85 N3f02608c6946438e8d0dae8599fc54f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Receptors, Pituitary Hormone
87 rdf:type schema:DefinedTerm
88 N61dd44e4e9ba49e8b1cc329334ffe88f schema:name pubmed_id
89 schema:value 2508784
90 rdf:type schema:PropertyValue
91 N62afd556a4694864b55d98e252ae276a schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N69e12c17cc6b403eadff76b1eaeb305c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Catechol Oxidase
95 rdf:type schema:DefinedTerm
96 N7313207e4c7b4c34a39be0c177c9e8a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Monophenol Monooxygenase
98 rdf:type schema:DefinedTerm
99 N797889fed9014293a45b7739d3f1f4e1 rdf:first sg:person.016612034677.24
100 rdf:rest N3599a768250b4907b2c123f4d062ba9c
101 N7bad803767d2472c9932ba2f423b5bab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Levodopa
103 rdf:type schema:DefinedTerm
104 N9bccd93b6aec44108499357384bd0e36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Melanocyte-Stimulating Hormones
106 rdf:type schema:DefinedTerm
107 Nb17ab386b9d144bda9c4f7edddffbe6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Tumor Cells, Cultured
109 rdf:type schema:DefinedTerm
110 Nc0b44f7867bd4a29baf3c7efbafa99d0 rdf:first sg:person.01357521676.69
111 rdf:rest rdf:nil
112 Nc6589ca19b0c4b3f9a322b81dfb8b069 schema:issueNumber 5
113 rdf:type schema:PublicationIssue
114 Nc7e8b19dcca6443494f04a5219cdab34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Animals
116 rdf:type schema:DefinedTerm
117 Nd2bd9c5567d24b21a591baf5a40dc19d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Melanoma, Experimental
119 rdf:type schema:DefinedTerm
120 Ne3f76dcaa3824de6a405ab37bbb2e8c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Enzyme Induction
122 rdf:type schema:DefinedTerm
123 Ne5fb7c3903b14bee9e8ac99b8da02894 schema:name doi
124 schema:value 10.1007/bf01119801
125 rdf:type schema:PropertyValue
126 Ne83c5c97416141229aec90556cbff548 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Kinetics
128 rdf:type schema:DefinedTerm
129 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
130 schema:name Biological Sciences
131 rdf:type schema:DefinedTerm
132 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
133 schema:name Biochemistry and Cell Biology
134 rdf:type schema:DefinedTerm
135 sg:grant.2465828 http://pending.schema.org/fundedItem sg:pub.10.1007/bf01119801
136 rdf:type schema:MonetaryGrant
137 sg:grant.2682086 http://pending.schema.org/fundedItem sg:pub.10.1007/bf01119801
138 rdf:type schema:MonetaryGrant
139 sg:journal.1092277 schema:issn 0144-8463
140 1573-4935
141 schema:name Bioscience Reports
142 schema:publisher Portland Press
143 rdf:type schema:Periodical
144 sg:person.01173347004.61 schema:affiliation grid-institutes:grid.47100.32
145 schema:familyName Jastreboff
146 schema:givenName Pawel
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173347004.61
148 rdf:type schema:Person
149 sg:person.01357521676.69 schema:affiliation grid-institutes:grid.47100.32
150 schema:familyName Pawelek
151 schema:givenName John
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357521676.69
153 rdf:type schema:Person
154 sg:person.016612034677.24 schema:affiliation grid-institutes:grid.47100.32
155 schema:familyName Slominski
156 schema:givenName Andrzej
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612034677.24
158 rdf:type schema:Person
159 sg:pub.10.1007/bf01122128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021084285
160 https://doi.org/10.1007/bf01122128
161 rdf:type schema:CreativeWork
162 grid-institutes:grid.47100.32 schema:alternateName Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
163 Department of Surgery, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
164 schema:name Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
165 Department of Surgery, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
166 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...