Normal levels of serum corticosterone and hepatic glucocorticoid receptors in obese (fa/fa) rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-11

AUTHORS

Narinder Singh Shargill, Ibtisam Al-Baker, David A. York

ABSTRACT

In an attempt to understand the hyper-responsiveness to glucocorticoids that is characteristic of genetically obese fa/fa rats, we have measured the levels of free corticosterone in serum from lean and obese rats as well as the number of “cytosolic” and "nuclear" binding sites in livers of these rats. Both the lean and obese rats had similar amounts of free corticosterone available for biological activity at 4 weeks and 10 weeks of age. Measurement of glucocorticoid binding to hepatic glucocorticoid receptors failed to show any differences between genotypes leading to the suggestion that the abnormal glucocorticoid response in obese rats may be due either to post-receptor defects or to a permissive action of the steroid in the expression of the fa/fa genotype. More... »

PAGES

843-851

References to SciGraph publications

  • 1980. Studies on the Mechanism of Glucocorticoid Hormone Action in GENE REGULATION BY STEROID HORMONES
  • 1979. Glucocorticoid Hormone Action in NONE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01119475

    DOI

    http://dx.doi.org/10.1007/bf01119475

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026616029

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3449126


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