Effects of actinomycin D and cycloheximide on the increase in tyrosinase activity of hamster amelanotic View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-12

AUTHORS

A. Słomiński, A. Bomirski, P. W. D. Ścisłowski, S. Żołnierowicz

ABSTRACT

Tyrosinase activity in the Ab hamster amelanotic melanoma ceils cultured in serum-free Eagle's MEM increased 3 times after 6 h of primary cell culture. This increase was inhibited completely by cycloheximide, while actinomycin D had no effect on this process. After 24 h of culture in MEM with calf serum, further increase of the tyrosinase activity was inhibited by both cycloheximide and actinomycin D. The data presented may indicate that the increase of tyrosinase activity in the primary cell culture of the Ab melanoma is due initially to the unblocking of translation and later to the activation of transcription of the gene controlling the enzyme. More... »

PAGES

1059-1064

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01116699

DOI

http://dx.doi.org/10.1007/bf01116699

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053025817

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6442169


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