Arrhenius plot characteristics of adipocyte-plasma-membrane adenylate cyclase activity in lean and genetically obese (ob/ob) mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-12

AUTHORS

R. R. French, D. A. York

ABSTRACT

Arrhenius plots of fluoride- and guanine-nucleotide-stimulated adenylate cyclase activity were linear in adipocyte plasma membranes from lean and obese (ob/ob) mice . Arrhenius plots of isoprenaline-stimulated adenylate cyclase activity in hepatic plasma membranes biphasic in both groups. The results were biphasic in membranes from Jean mice but linear in membranes from obese mice. In contrast, Arrhenius plots of glucagon-stimulated adenylate cyclase activity in hepatic plasma membranes were biphasic in both groups. The results suggest that the coupling between the β-receptor and the regulatory unit of adenylate cyclase, which has been observed to be defective in adipocyte plasma membranes from obese mice, is influenced by a different lipid environment in membranes from obese animals. More... »

PAGES

1001-1008

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01116692

DOI

http://dx.doi.org/10.1007/bf01116692

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028233862

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6099153


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