Selective breeding for alcohol preference and associated responses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-03

AUTHORS

Ting-Kai Li, Lawrence Lumeng, Donald P. Doolittle

ABSTRACT

Selective breedng for high and low alcohol-drinking preference has produced rat lines useful for studying the nature of excessive alcohol-seeking behavior. Compared with the alcohol-nonpreferring line, the preferring animals exhibit heightened responsivity to the low-dose activating effects of ethanol as well as enhanced capacity for developing tolerance to the aversive, behaviorally impairing effects of ethanol. The preferring animals exhibit lower brain serotonin and dopamine neurotransmitter activity as well as differences in other neurotransmitter neuromodulator systems, compared with the alcoholnonpreferring animals. More... »

PAGES

163-170

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01067421

DOI

http://dx.doi.org/10.1007/bf01067421

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041994436

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8099788


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