Effect of phenobarbital on the delayed neurotoxicity of leptophos in hens View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-11

AUTHORS

Nobuhiro Konno, Kiyoshi Katoh, Yasuaki Yamaguchi, Toru Yamauchi, Masaaki Fukushima

ABSTRACT

Intravenous administration of leptophos [O-(4-bromo-2,5-dichlorophenyl)O-methyl phenylphosphonothioate] caused a delayed neurotoxic effect in hens similar to that produced by oral and dermal administration. The intravenous (IV) ED50 for producing ataxia was estimated to be 21.6 mg/kg, less than one-tenth of the oral ED50 value. Pretreatment of the hens with the drug metabolizing enzyme inducer, phenobarbital (PB), caused a marked change in the biological half-life of leptophos in plasma. Plasma leptophos concentrations decreased in a first-order manner in control hens with a half-life of 36.0 min. In hens pretreated with PB, the elimination of leptophos from plasma consisted of at least two exponential phases, and the half-lives of the first and second phases were approximately 20 min and 140 min, respectively. When the birds received 40 mg/kg of leptophos IV, the incidence of ataxia was 8/18 (affected/tested) in the hens pretreated with PB and 19/19 in the hens without pretreatment. Phenobarbital significantly decreased the incidence of delayed neurotoxic signs (p < 0.01). The pretreatment of hens with PB resulted in a 59 to 69% decrease in the leptophos level in tissues including the brain and spinal cord after IV administration of 40 mg/kg. The results suggest that the protective effect of PB on delayed neurotoxicity is associated with a decreased concentration of leptophos in the target tissue(s). More... »

PAGES

653-659

References to SciGraph publications

  • 1977-12. Metabolism of14C-leptophos in the rat in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 1974-01. Neurotoxic effect of leptophos in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1976-06. Pharmacokinetics of a neurotoxic oral dose of leptophos in hens in ARCHIVES OF TOXICOLOGY
  • 1973-06. The metabolism ofO-(4-bromo-2, 5-dichlorophenyl)O-methyl phenylphosphonothioate (leptophos) in white mice and on cotton plants in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01054912

    DOI

    http://dx.doi.org/10.1007/bf01054912

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035591903

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2431660


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    188 schema:name Department of Public Health, Fukushima Medical College, 960, Fukushima, Japan
    189 rdf:type schema:Organization
     




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