The ability of latrotoxin-like brain protein to induce fusion of negatively charged liposomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-09

AUTHORS

I. O. Trikash, Ya. T. Terletskaya, L. I. Kolchinskaya, M. K. Malysheva, K. S. Serdyuk

ABSTRACT

A latrotoxin-like protein isolated from the bovine brain promoted fusion of negatively charged liposomes consisting of phosphatidylcholine, phosphatidylethanolamine, and cardiolipin in a molar ratio of 2:3:5. The fusogenic effect significantly increased at mild acidic pH 6.0 and under denaturation (4 M urea, 0.1% SDS). Using ANS as the fluorescent probe, it was found that hydrophobicity of the latrotoxin-like protein increases along with the fusogenic activity. We hypothesize the existence in the protein molecule of conformational changes promoting the fusion, and the possible participation of the protein in neurosecretion processes. More... »

PAGES

267-270

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01054256

DOI

http://dx.doi.org/10.1007/bf01054256

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044736490


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine", 
          "id": "http://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trikash", 
        "givenName": "I. O.", 
        "id": "sg:person.060040255.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.060040255.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine", 
          "id": "http://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terletskaya", 
        "givenName": "Ya. T.", 
        "id": "sg:person.015323536244.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015323536244.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine", 
          "id": "http://www.grid.ac/institutes/grid.418751.e", 
          "name": [
            "Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kolchinskaya", 
        "givenName": "L. I.", 
        "id": "sg:person.01064235363.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064235363.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine", 
          "id": "http://www.grid.ac/institutes/grid.418751.e", 
          "name": [
            "Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malysheva", 
        "givenName": "M. K.", 
        "id": "sg:person.01233405241.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233405241.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine", 
          "id": "http://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Serdyuk", 
        "givenName": "K. S.", 
        "type": "Person"
      }
    ], 
    "datePublished": "1993-09", 
    "datePublishedReg": "1993-09-01", 
    "description": "A latrotoxin-like protein isolated from the bovine brain promoted fusion of negatively charged liposomes consisting of phosphatidylcholine, phosphatidylethanolamine, and cardiolipin in a molar ratio of 2:3:5. The fusogenic effect significantly increased at mild acidic pH 6.0 and under denaturation (4 M urea, 0.1% SDS). Using ANS as the fluorescent probe, it was found that hydrophobicity of the latrotoxin-like protein increases along with the fusogenic activity. We hypothesize the existence in the protein molecule of conformational changes promoting the fusion, and the possible participation of the protein in neurosecretion processes.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01054256", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016854", 
        "issn": [
          "0090-2977", 
          "1573-9007"
        ], 
        "name": "Neurophysiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "keywords": [
      "latrotoxin-like protein", 
      "fusogenic effect", 
      "fluorescent probe", 
      "protein molecules", 
      "conformational changes", 
      "fusogenic activity", 
      "probe", 
      "molecules", 
      "fusion", 
      "liposomes", 
      "existence", 
      "molar ratio", 
      "ANS", 
      "ratio", 
      "process", 
      "effect", 
      "denaturation", 
      "hydrophobicity", 
      "increase", 
      "phosphatidylcholine", 
      "cardiolipin", 
      "changes", 
      "protein increases", 
      "ability", 
      "protein", 
      "pH 6.0", 
      "phosphatidylethanolamine", 
      "possible participation", 
      "activity", 
      "brain", 
      "participation", 
      "brain proteins", 
      "bovine brain", 
      "mild acidic pH 6.0", 
      "acidic pH 6.0", 
      "latrotoxin-like protein increases", 
      "neurosecretion processes", 
      "latrotoxin-like brain protein"
    ], 
    "name": "The ability of latrotoxin-like brain protein to induce fusion of negatively charged liposomes", 
    "pagination": "267-270", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044736490"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01054256"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01054256", 
      "https://app.dimensions.ai/details/publication/pub.1044736490"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_248.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01054256"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01054256'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01054256'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01054256'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01054256'


 

This table displays all metadata directly associated to this object as RDF triples.

126 TRIPLES      21 PREDICATES      64 URIs      56 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01054256 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N712a820542fa4d608007cab2ff2d471c
4 schema:datePublished 1993-09
5 schema:datePublishedReg 1993-09-01
6 schema:description A latrotoxin-like protein isolated from the bovine brain promoted fusion of negatively charged liposomes consisting of phosphatidylcholine, phosphatidylethanolamine, and cardiolipin in a molar ratio of 2:3:5. The fusogenic effect significantly increased at mild acidic pH 6.0 and under denaturation (4 M urea, 0.1% SDS). Using ANS as the fluorescent probe, it was found that hydrophobicity of the latrotoxin-like protein increases along with the fusogenic activity. We hypothesize the existence in the protein molecule of conformational changes promoting the fusion, and the possible participation of the protein in neurosecretion processes.
7 schema:genre article
8 schema:inLanguage en
9 schema:isAccessibleForFree false
10 schema:isPartOf N4a9d0dd77d764ebcae336a1c4f188d28
11 Nf90c2aae9d1c4b2992440d57568b3dd4
12 sg:journal.1016854
13 schema:keywords ANS
14 ability
15 acidic pH 6.0
16 activity
17 bovine brain
18 brain
19 brain proteins
20 cardiolipin
21 changes
22 conformational changes
23 denaturation
24 effect
25 existence
26 fluorescent probe
27 fusion
28 fusogenic activity
29 fusogenic effect
30 hydrophobicity
31 increase
32 latrotoxin-like brain protein
33 latrotoxin-like protein
34 latrotoxin-like protein increases
35 liposomes
36 mild acidic pH 6.0
37 molar ratio
38 molecules
39 neurosecretion processes
40 pH 6.0
41 participation
42 phosphatidylcholine
43 phosphatidylethanolamine
44 possible participation
45 probe
46 process
47 protein
48 protein increases
49 protein molecules
50 ratio
51 schema:name The ability of latrotoxin-like brain protein to induce fusion of negatively charged liposomes
52 schema:pagination 267-270
53 schema:productId N9198dadccfa14bfda09bc6023933e650
54 Na57a0bed7f7d4b59886802e4fa6e2b7e
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044736490
56 https://doi.org/10.1007/bf01054256
57 schema:sdDatePublished 2021-12-01T19:08
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher Na40b7c9c444846b2bce3b9fd7129af28
60 schema:url https://doi.org/10.1007/bf01054256
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N11c2ac356aa8480c9e0d7b26bc5a8179 rdf:first sg:person.015323536244.18
65 rdf:rest Ncae3e554daa240aebbee1a39a4a4f580
66 N259dda0f3cf44e2fa22987bc92492015 rdf:first sg:person.01233405241.45
67 rdf:rest Nd3e769be2e3347c39cb29f8d5cfc1ef8
68 N4a9d0dd77d764ebcae336a1c4f188d28 schema:volumeNumber 25
69 rdf:type schema:PublicationVolume
70 N712a820542fa4d608007cab2ff2d471c rdf:first sg:person.060040255.77
71 rdf:rest N11c2ac356aa8480c9e0d7b26bc5a8179
72 N9198dadccfa14bfda09bc6023933e650 schema:name dimensions_id
73 schema:value pub.1044736490
74 rdf:type schema:PropertyValue
75 Na40b7c9c444846b2bce3b9fd7129af28 schema:name Springer Nature - SN SciGraph project
76 rdf:type schema:Organization
77 Na57a0bed7f7d4b59886802e4fa6e2b7e schema:name doi
78 schema:value 10.1007/bf01054256
79 rdf:type schema:PropertyValue
80 Ncae3e554daa240aebbee1a39a4a4f580 rdf:first sg:person.01064235363.82
81 rdf:rest N259dda0f3cf44e2fa22987bc92492015
82 Nd3e769be2e3347c39cb29f8d5cfc1ef8 rdf:first Ne6a01b454faa4c0c96d719ba1a79f2c8
83 rdf:rest rdf:nil
84 Ne6a01b454faa4c0c96d719ba1a79f2c8 schema:affiliation grid-institutes:grid.419966.5
85 schema:familyName Serdyuk
86 schema:givenName K. S.
87 rdf:type schema:Person
88 Nf90c2aae9d1c4b2992440d57568b3dd4 schema:issueNumber 5
89 rdf:type schema:PublicationIssue
90 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
91 schema:name Medical and Health Sciences
92 rdf:type schema:DefinedTerm
93 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
94 schema:name Neurosciences
95 rdf:type schema:DefinedTerm
96 sg:journal.1016854 schema:issn 0090-2977
97 1573-9007
98 schema:name Neurophysiology
99 schema:publisher Springer Nature
100 rdf:type schema:Periodical
101 sg:person.01064235363.82 schema:affiliation grid-institutes:grid.418751.e
102 schema:familyName Kolchinskaya
103 schema:givenName L. I.
104 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064235363.82
105 rdf:type schema:Person
106 sg:person.01233405241.45 schema:affiliation grid-institutes:grid.418751.e
107 schema:familyName Malysheva
108 schema:givenName M. K.
109 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233405241.45
110 rdf:type schema:Person
111 sg:person.015323536244.18 schema:affiliation grid-institutes:grid.419966.5
112 schema:familyName Terletskaya
113 schema:givenName Ya. T.
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015323536244.18
115 rdf:type schema:Person
116 sg:person.060040255.77 schema:affiliation grid-institutes:grid.419966.5
117 schema:familyName Trikash
118 schema:givenName I. O.
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.060040255.77
120 rdf:type schema:Person
121 grid-institutes:grid.418751.e schema:alternateName Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine
122 schema:name Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine
123 rdf:type schema:Organization
124 grid-institutes:grid.419966.5 schema:alternateName Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine
125 schema:name Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine
126 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...