Ontology type: schema:ScholarlyArticle
1996-12
AUTHORSDaniele Bouhours, Christine Pourcel, Jean-Francois Bouhours
ABSTRACTGlycosphingolipids were isolated from primary cultures of porcine endothelial cells labelled with14C-galactose or14C-glucosamine. They were characterized by their mobility on thin layer chromatogram, their sensitivity to exoglycosidases, and their labelling with antibodies. In addition to the major glycosphingolipids, globotetra-and globotriaosylceramide, minor ones were identified as penta-and heptaglycosylceramide of the neolactoseries terminated by either Galα1–3Gal-(xenoreactive epitope) or Fucα1–2Gal-(H determinant). Two gangliosides were found, GM3 and GD3, andN-glycolylneuraminic acid was their major sialic acid. Therefore, porcine endothelial cells differ from human endothelial cells by expression of glycosphingolipids that are absent in man: two Galα1–3Gal-terminated glycolipids recognized by human natural antibodies, and twoN-glycolylneuraminic acid-terminated gangliosides which are potent immunogens. More... »
PAGES947-953
http://scigraph.springernature.com/pub.10.1007/bf01053190
DOIhttp://dx.doi.org/10.1007/bf01053190
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8981086
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