Proteolysis and invasiveness of brain tumors: Role of urokinase-type plasminogen activator receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-06

AUTHORS

Sanjeeva Mohanam, Raymond E. Sawaya, Masaaki Yamamoto, Janet M. Bruner, Garth L. Nicholson, Jasti S. Rao

ABSTRACT

The cellular receptor for urokinase-type plasminogen activator (uPAR) in glioblastoma cell lines has been identified and found to be similar to the uPAR expressed by other tumor cell lines. Increased levels of uPAR have been found in primary malignant brain tumor tissues, especially highly malignant glioblastoma, and, to a lesser degree, in malignant astrocytomas, suggesting that this receptor might be involved in efficient activation of pro-uPA and confinement of uPA activity on the cell surface of invading brain tumors. The cell surface uPARs in gliomas could constitute an optimum environment for the generation and activity of plasmin, which is known to play a crucial role in the dissolution of the extracellular matrix during tumor cell invasion.In situ hybridization studies have shown that uPAR mRNA is expressed abundantly in tumor cells and is consistently present at the invasive edges of malignant gliomas. These results imply that uPAR is involved in plasmincatalyzed proteolysis during glioma invasion and that interference with the uPA∶uPAR interactions could constitute a novel approach for developing therapeutic strategies to counteract invasion of brain tumors. More... »

PAGES

153-160

References to SciGraph publications

  • 1992-05. The role of proteolytic enzymes in cancer invasion and metastasis in CLINICAL & EXPERIMENTAL METASTASIS
  • 1990-12. Cathepsin B and its endogenous inhibitors: the role in tumor malignancy in CANCER AND METASTASIS REVIEWS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01052890

    DOI

    http://dx.doi.org/10.1007/bf01052890

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009280850

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7745467


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    203 grid-institutes:grid.240145.6 schema:alternateName Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    204 Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    205 Department of Tumor Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    206 schema:name Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    207 Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    208 Department of Tumor Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    209 rdf:type schema:Organization
     




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