Enantioselective oxidation of mandelic acid using a phenylmalonate metabolizing pathway of a soil bacteriumAlcaligenesbronchisepticus KU 1201 View Full Text


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Article Info

DATE

1992-05

AUTHORS

Kenji Miyamoto, Hiromichi Ohta

ABSTRACT

The metabolic pathway of phenylmalonic acid byAlcaligenesbronchisepticus KU1201, which catalyzes the asymmetric decarboxylation of α-aryl-α-methylmalonic acids to α-arylpropionic acids, is demonstrated. Enantioselective oxidation of mandelic acid was investigated using the metabolizing pathway in this strain. Incubation of (±)-mandelic acid withA.bronchisepticus afforded optically pure (R)-one accompanied by benzoylformic acid and benzoic acid. This enzymatic oxidation is also applicable to various substituted mandelic acids. More... »

PAGES

363-366

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01021248

DOI

http://dx.doi.org/10.1007/bf01021248

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000352851


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